A5039728552- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Maternal and Perinatal Health Interventions
- Menstrual Health and Disorders
- dental development and anomalies
- Biochemical effects in animals
- Grief, Bereavement, and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- Animal Disease Management and Epidemiology
- Malaria Research and Control
- Neuroendocrine regulation and behavior
- Homicide, Infanticide, and Child Abuse
- Thermoregulation and physiological responses
- Influenza Virus Research Studies
- Prion Diseases and Protein Misfolding
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Electrolyte and hormonal disorders
- Insect Resistance and Genetics
- Respiratory Support and Mechanisms
- Renal function and acid-base balance
- Fetal and Pediatric Neurological Disorders
- Dengue and Mosquito Control Research
University of Glasgow
2021-2022
University of Liverpool
2015-2020
Animal and Plant Health Agency
2020
Royal Stoke University Hospital
1993-2007
Keele University
2000-2007
In a two-stage screening procedure using the Edinburgh Postnatal Depression Scale and Goldberg's Standardised Psychiatric Interview, 232 women six months after delivery were compared with control individually matched for age, marital status number of children, obtained from general practitioner lists, who not pregnant nor had baby in previous 12 months. No significant difference point prevalence depression at was found between postnatal (9.1%) (8.2%) six-month period (13.8% postnatal, 13.4%...
The objective of the study was to establish frequency depression during pregnancy and puerperium, its relationship marital disharmony sociodemographic variables. A prospective longitudinal carried out in a district general hospital West Midlands, UK. cohort consisted 417 women booked for confinement at hospital. Depression measured as proportion high scores (> 14) on Edinburgh Postnatal Scale (EPDS) determined by Spanier Dyadic Adjustment Scale. Using recommended cut-offs, 41/417 (9.8%) were...
To date there has been no evidence of mosquito-borne virus transmission public health concern in the UK, despite occurrence more than 30 species mosquito, including putative vectors arboviruses. The saltmarsh mosquito Ochlerotatus detritus [syn. Aedes (Ochlerotatus) detritus] is locally common parts UK where it can be a voracious feeder on people. Here, we assess competence O. for three major arboviruses: dengue (DENV), chikungunya (CHIKV) and West Nile (WNV) using adult mosquitoes reared...
Abstract Livestock abortion is an important cause of productivity losses worldwide and many infectious causes are zoonotic pathogens that impact on human health. Little known about the relative importance livestock in Africa, including subsistence farming communities critically dependent for food, income, wellbeing. We conducted a prospective cohort study abortion, supported by cross-sectional serosurveillance, to determine aetiologies abortions Tanzania. This approach generated several...
Background This paper reports further data from the Stoke study of postnatal depression and examines whether psychosocial characteristics symptom profiles differ between control depression. Method Two hundred thirty-two non-postnatal women were screened with Edinburgh Postnatal Depression Scale; all high scorers a sample low interviewed Standardised Psychiatric Interview modified Social Maladjustment Schedule. was diagnosed using Research Diagnostic Criteria. Results but not associated poor...
Abstract Background There has been no evidence of transmission mosquito-borne arboviruses equine or human health concern to date in the UK. However, recent years there have a number outbreaks viral diseases spread by vectors Europe. These events, conjunction with increasing rates globalisation and climate change, led over future risk disease northern Europe highlighted importance being prepared for potential outbreaks. Here we assess several UK mosquito species their transmit important both...
Mosquito-borne Zika virus (ZIKV) transmission has almost exclusively been detected in the tropics despite distributions of its primary vectors extending farther into temperate regions. Therefore, it is unknown whether ZIKV's range reached a temperature-dependent limit, or if can spread climates. Using field-collected mosquitoes for biological relevance, we found that two common mosquito species, Aedes albopictus and Ochlerotatus detritus, were competent ZIKV. We orally exposed to ZIKV held...
In Brief OBJECTIVE: To assess whether the G allele of serotonin receptor 1A C(-1019)G polymorphism is associated with premenstrual dysphoric disorder. METHODS: The study sample comprised 53 women clinically diagnosed disorder (age range 27–46 years, mean 37.7 years) and 51 healthy control subjects 22–48 36.2 years). was genotyped compared between two groups. RESULTS: contrast to postulated "high-risk" G/G genotype, there a marked overrepresentation C/C genotype in group (P=.034; odds ratio...
There is growing concern about the increasing risk of disease outbreaks caused by arthropod-borne viruses (arboviruses) in both human beings and animals. are several mosquito-borne viral diseases that cause varying levels morbidity mortality horses can have substantial welfare economic ramifications. While none has been recorded UK, vector species for some these present, suggesting UK equines may be at risk. The authors undertook, therefore, first study mosquito on equine premises UK....
Increased globalisation and climate change have led to concern about the increasing risk of arthropod‐borne virus (arbovirus) outbreaks globally. An outbreak equine arboviral disease in northern Europe could impact significantly on welfare, result economic losses. Early identification by horse owners may help limit spread. In order determine what understand diseases horses their vectors, authors undertook an open, cross‐sectional online survey UK owners. The questionnaire was distributed...
Abstract Background. Selected ion flow tube mass spectrometry allows trace gas quantification in exhaled breath and the air/vapor above liquids (headspace) down to 10 parts‐per‐billion level. During selected investigation of volatile compounds emitted by urine, high acetone levels were incidentally identified headspace urine from healthy female volunteers around their mid‐cycle. Hence, this study was designed measure throughout menstrual cycle. Methods. Using we measured daily concentrations...
A 3-year-old male entire boxer presented with a 3-week history of lethargy, hyporexia, hypersalivation, low-head carriage, pelvic limb tremors and intermittent vestibular ataxia. Neurological examination revealed kyphosis, wide-based stance, an alternating head tilt, left leaning, bilateral positional ventral strabismus vertical nystagmus. Exacerbation neurological signs increased extensor tone in all limbs were noticed after dorsal extension the neck. Neuroanatomical localisation was...
Two cases of pre-partum psychosis are described. Both patients had previous episodes puerperal but no non-puerperal illnesses. The possible relationship and post-partum is discussed.
Abstract Background Hypohidrotic ectodermal dysplasia (HED) is a congenital syndrome of mammals affecting organs and tissues origin characterized by absence or hypoplasia hair, teeth, eccrine glands. The disorder has been reported in several species, including humans, mice, dogs cattle, associated with variants genes the ectodysplasin pathway, X-linked A ( EDA ) gene. Until now, nine pathogenic have found bovine Here we report novel variant crossbreed male Belgian Blue calf HED, provide an...
The resistance of H-type and L-type BSE prions to autoclaving under EU regulation conditions for specified risk material is unknown. We employed transgenic mouse (bovinized line tg1896) bioassay assess the efficacy such decontamination on L- BSE. For each source, titre calculation was based comparison incubation period attack rate prior after decontamination. infectious reduced by at least 9.40 log10 3.94 log10. In fact, no infectivity detected or post-inactivation even a 10–1 dilution.
Abstract Livestock abortion is an important cause of productivity losses worldwide and many infectious causes are zoonotic pathogens that impact on human health. Little known about the relative importance livestock in Africa, including subsistence farming communities critically dependent for food, income, wellbeing. We conducted a prospective cohort study abortion, supported by cross-sectional serosurveillance, to determine aetiologies abortions Tanzania. This approach generated several...
BPIFA1 is a member the bactericidal/permeability-increasing (BPI) protein family and structurally similar to other BPIF members with demonstrated innate immune roles. It produced mainly in mammalian respiratory tract has been implicated airway host defense against pathogens. However, function of this yet unresolved many species by elucidating will aid clarify its physiological role within lungs. The objective study was assess expression response Influenza A virus. Using knockout mice, we...