A5042186848- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Insect symbiosis and bacterial influences
- COVID-19 Clinical Research Studies
- Biosensors and Analytical Detection
- Plant Virus Research Studies
- Insect Resistance and Genetics
- Enzyme Structure and Function
- Dental Research and COVID-19
- Malaria Research and Control
- Evolution and Genetic Dynamics
- Plant biochemistry and biosynthesis
- Viral Infectious Diseases and Gene Expression in Insects
- Parasitic Diseases Research and Treatment
- Infection Control and Ventilation
- HIV Research and Treatment
- Parasite Biology and Host Interactions
- vaccines and immunoinformatics approaches
- Respiratory viral infections research
- Parasites and Host Interactions
- Viral Infections and Outbreaks Research
- Innovative Microfluidic and Catalytic Techniques Innovation
University of Louisiana at Lafayette
2025
Liverpool School of Tropical Medicine
2019-2024
Brock University
2021-2024
University of Zurich
2024
The University of Texas Medical Branch at Galveston
2018-2021
St George's, University of London
2021
University of Bari Aldo Moro
2021
University of Liverpool
2020
National Institute for Health Research
2020
Aintree University Hospitals NHS Foundation Trust
2020
Abstract SARS-CoV-2 emerged from animals and is now easily transmitted between people. Sporadic detection of natural cases in alongside successful experimental infections pets, such as cats, ferrets dogs, raises questions about the susceptibility under conditions pet ownership. Here, we report a large-scale study to assess infection 919 companion living northern Italy, sampled at time frequent human infection. No tested PCR positive. However, 3.3% dogs 5.8% cats had measurable neutralizing...
Abstract The scientific community has responded to the coronavirus disease 2019 (COVID-19) pandemic by rapidly undertaking research find effective strategies reduce burden of this disease. Encouragingly, researchers from a diverse array fields are collectively working towards goal. Research with infectious severe acute respiratory syndrome 2 (SARS-CoV-2) is undertaken in high-containment laboratories; however, it often desirable work samples at lower-containment levels. To facilitate...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) not only affects the respiratory tract but also causes neurological symptoms such as loss of smell and taste, headache, fatigue or severe cerebrovascular complications. Using transgenic mice expressing human angiotensin-converting enzyme (hACE2), we investigated spatiotemporal distribution pathomorphological features in CNS following intranasal infection with SARS-CoV-2 variants, well after prior influenza A virus infection. Apart...
Abstract In the context of coronavirus disease 2019 (COVID-19) pandemic there has been an increase use antigen-detection rapid diagnostic tests (Ag-RDT). The performance Ag-RDT vary greatly between manufacturers and evaluating their analytical limit detection (LOD) become high priority. Here we describe a manufacturer-independent evaluation LOD 19 marketed using live SARS-CoV-2 spiked in different matrices: direct culture supernatant, dry swab, swab Amies. Additionally, was investigated...
Abstract PCR of upper respiratory specimens is the diagnostic standard for severe acute syndrome coronavirus 2 infection. However, saliva sampling an easy alternative to nasal and throat swabbing. We found similar viral loads in samples swab from 110 patients with disease.
Abstract Background Information on common markers of metabolic resistance in malaria vectors from countries sharing similar eco-climatic characteristics can facilitate coordination control. Here, we characterized populations the major vector Anopheles coluzzii Sahel region, spanning four sub-Saharan African countries: Nigeria, Niger, Chad and Cameroon. Results Genome-wide transcriptional analysis identified genes previously implicated pyrethroid and/or cross-resistance to other insecticides,...
COVID-19 is a spectrum of clinical symptoms in humans caused by infection with SARS-CoV-2. The coalescence SARS-CoV-2 seasonal respiratory viruses, particularly influenza global health concern. To understand this, transgenic mice expressing the human ACE2 receptor (K18-hACE2) were infected A virus (IAV) followed and host response effect on biology was compared to K18-hACE2 IAV or alone. sequentially showed reduced RNA synthesis, yet exhibited more rapid weight loss, severe lung damage...
We report the recent emergence of a novel beak and feather disease virus (BFDV) genotype in last remaining wild population critically endangered Orange-bellied Parrot (Neophema chrysogaster). This poses significant threat to recovery species potentially its survival wild. used PCR detect BFDV blood three psittacine (PBFD)–affected fledglings captured as founders for an existing captive breeding program. Complete genome sequence data from one these birds demonstrating 1,993-nucleotide-long...
SARS-CoV-2 originated in animals and is now easily transmitted between people. Sporadic detection of natural cases alongside successful experimental infections pets, such as cats, ferrets dogs, raises questions about the susceptibility under conditions pet ownership. Here we report a large-scale study to assess infection 817 companion living northern Italy, sampled at time frequent human infection. No tested PCR positive. However, 3.4% dogs 3.9% cats had measurable neutralizing antibody...
Quasispecies variants and recombination were studied longitudinally in an emergent outbreak of beak feather disease virus (BFDV) infection the orange-bellied parrot (Neophema chrysogaster). Detailed health monitoring small population size (<300 individuals) this critically endangered bird provided opportunity to track viral replication mutation events occurring a circular, single-stranded DNA over period four years within novel bottleneck population. Optimized PCR was used with different...
Abstract We detected severe acute respiratory syndrome coronavirus 2 in an otherwise healthy poodle living with 4 family members who had disease. observed antibodies serum samples taken from the dog, indicating seroconversion. Full-length genome sequencing showed that canine and human viruses were identical, suggesting human-to-animal transmission.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) extensively
Since chikungunya virus (CHIKV) was introduced into the Americas in 2013, its geographic distribution has rapidly expanded. Of 119 serum samples collected 2014 from febrile patients southern Mexico, 79% were positive for CHIKV or IgM against CHIKV. Sequencing results confirmed strains closely related to Caribbean isolates.
Although mosquitoes are major transmission vectors for pathogenic arboviruses, viral infection has little impact on mosquito health. This immunity is caused in part by RNA interference (RNAi) pathways that generate antiviral small interfering RNAs (siRNAs) and Piwi-interacting (piRNAs). RNAi also maintains genome integrity potently repressing transposon activity the germline soma. However, regulatory have not been systematically examined together mosquitoes. Therefore, we developed an...
We monitored the severe acute respiratory syndrome coronavirus 2 antibody response in seven dogs and two cats by using multispecies ELISA tests, plaque reduction neutralisation test virus neutralization. SARS-CoV-2 neutralizing antibodies pets persisted up to 10 months since first positive testing, thus replicating observations COVID-19 human patients.
Negeviruses are a group of insect-specific viruses (ISVs), known to infect only insects. They have been discovered over wide geographical and species range.
Introduction. The importance of human saliva in aerosol-based transmission SARS-CoV-2 is now widely recognized. However, little known about the efficacy virucidal mouthwash formulations against emergent variants concern and presence saliva.Hypothesis. Mouthwashes containing actives will have similar inactivation effects multiple retain saliva.Aim. To examine vitro to inactivate variants.Methodology. Inactivation by or absence was assayed using ASTM International Standard E1052-20...
Abstract The scientific community has responded to the COVID-19 pandemic by rapidly undertaking research find effective strategies reduce burden of this disease. Encouragingly, researchers from a diverse array fields are collectively working towards goal. Research with infectious SARS-CoV-2 is undertaken in high containment laboratories, however, it often desirable work samples at lower levels. To facilitate transfer we have tested methods commonly used inactivate virus and prepare sample...
Companion animals are susceptible to SARS-CoV-2 infection and sporadic cases of pet infections have occurred in the United Kingdom. Here we present first large-scale serological survey neutralising antibodies dogs cats UK. Results reported for 688 sera (454 canine, 234 feline) collected by a large veterinary diagnostic laboratory routine haematology during three time periods; pre-COVID-19 (January 2020), wave UK human (April-May 2020) second (September 2020-February 2021). Both those from...
Abstract As one of the primary points entry xenobiotic substances and infectious agents into body, lungs are subject to a range dysfunctions diseases that together account for significant number patient deaths. In view this, there is an outstanding need in vitro systems which assess impact both lungs. To address this issue, we have developed protocol generate airway epithelial basal-like cells from induced pluripotent stem cells, simplifies manufacture cellular models human upper airways....
Abstract Flaviviruses have increasingly emerged and re-emerged in recent decades, infecting millions of people annually. Zika virus is particularly concerning due to its associated pathological complications, including microcephaly newborns Guillain-Barré syndrome adults, posing a significant threat public health. Despite efforts made by the scientific community, no licensed drugs against flaviviruses been developed. Medicinal plants show promise as novel source antiviral agents, they...
A key element for the prevention and management of coronavirus disease 2019 is development effective therapeutics. Drug combination strategies offer several advantages over monotherapies. They have potential to achieve greater efficacy, increase therapeutic index drugs reduce emergence drug resistance. We assessed in vitro synergistic interaction between remdesivir ivermectin, both approved by US Food Administration, demonstrated enhanced antiviral activity against severe acute respiratory...