A5039540154- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Receptor Mechanisms and Effects
- Herpesvirus Infections and Treatments
- Toxoplasma gondii Research Studies
- Neuropeptides and Animal Physiology
- Parasitic Infections and Diagnostics
- Phosphodiesterase function and regulation
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Cytomegalovirus and herpesvirus research
- Hereditary Neurological Disorders
University of Glasgow
2021
Moredun Research Institute
2019-2020
National Institute of Neurological Disorders and Stroke
1994
National Institutes of Health
1994
Toxoplasma gondii is a zoonotic parasite of global importance. The outcome infection in humans can depend on number factors including the infecting stage parasite, inoculating dose and virulence strain. Molecular epidemiological studies have demonstrated an abundance atypical strains T. South America, many which been associated with more severe sequelae infection. aim this study was to compare isolated Caribbean virulent Brazilian strain avirulent European One hundred twenty Swiss CD-1 mice...
Y-79 human retinoblastoma cells can be induced to express significant quantities of functional D2 dopamine receptors after attachment and differentiation with sodium butyrate. In membranes prepared from differentiated cells, the dopaminergic antagonist [3H] methylspiperone exhibits a KD 77 pm Bmax 60 fmol/mg protein, whereas [125I]iodosulpride reveals 0.77 nM 40 protein. Dopamine also induces pharmacologically specific, pertussis toxin-sensitive, dose-dependent inhibition...
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), an irreversible and nonselective protein-modifying reagent, has been used extensively in studies involving inactivation of receptors. Here, we present N-(p-isothiocyanatophenethyl)spiperone (NIPS), a novel highly selective inactivator D2 but not D1 In vitro studies, NIPS exhibited apparent Ki 10 nM for [3H]methylspiperone binding to receptors rat striatum. Preincubation the striatal membranes with followed by extensive washing resulted...
Gangliosides are expressed on plasma membranes throughout the body and enriched in nervous system. A critical role for complex a- b-series gangliosides central peripheral system ageing has been established through transgenic manipulation of enzymes ganglioside biosynthesis. Disrupting GalNAc-transferase (GalNAc-T), thus eliminating all (with consequent over-expression GM3 GD3) leads to an age-dependent neurodegeneration. Mice that express only (double knockout produced by crossing...