A5022622849- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Nosocomial Infections in ICU
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Hip and Femur Fractures
- Family and Patient Care in Intensive Care Units
- Neonatal Respiratory Health Research
- Central Venous Catheters and Hemodialysis
- Antibiotics Pharmacokinetics and Efficacy
- Healthcare Decision-Making and Restraints
- Nutrition and Health in Aging
- Emergency and Acute Care Studies
- Vascular Procedures and Complications
- Systemic Lupus Erythematosus Research
- Anesthesia and Neurotoxicity Research
- Pericarditis and Cardiac Tamponade
- Neurosurgical Procedures and Complications
- Cardiovascular Issues in Pregnancy
- Takotsubo Cardiomyopathy and Associated Phenomena
Tokushima University
2013-2024
Tokushima University Hospital
2011-2023
Kurashiki Central Hospital
2020
Massachusetts General Hospital
2013-2018
Anna Needs Neuroblastoma Answers
2018
Harvard University
2013-2017
Vanderbilt University Medical Center
2016
Vanderbilt University
2015
Boston University
2014
Academy of Emergency Medicine and Care
2009-2014
The use of arterial partial pressure carbon dioxide (PaCO2) as a target intervention to manage elevated intracranial (ICP) and its effect on clinical outcomes remain unclear. We aimed describe targets for PaCO2 in acute brain injured (ABI) patients assess the occurrence abnormal values during first week intensive care unit (ICU). secondary aim was association with in-hospital mortality. carried out analysis multicenter prospective observational study involving adult invasively ventilated...
Abstract Background Diaphragm atrophy is observed in mechanically ventilated patients. However, the not investigated other respiratory muscles. Therefore, we conducted a two-center prospective observational study to evaluate changes diaphragm and intercostal muscle thickness Methods Consecutive adult patients who were expected be longer than 48 h ICU enrolled. measured on days 1, 3, 5, 7 with ultrasonography. The primary outcome was direction of change thickness, secondary outcomes...
Lower limb muscle atrophy is often observed in critically ill patients. Although upper muscles can undergo atrophy, it remains unclear how this associated with clinical outcomes. We hypothesized that mortality and impairments physical function.In two-center prospective observational study, we included adult patients who were expected to require mechanical ventilation for > 48 h remain the intensive care unit (ICU) 5 days. used ultrasound evaluate cross-sectional area of biceps brachii on...
There is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality critical care populations. We aimed describe MP ventilated patients with ABI, evaluate clinical outcomes.In this preplanned, secondary analysis of a prospective, multi-center, observational cohort study (ENIO, NCT03400904), we included adult ABI (Glasgow Coma Scale ≤ 12 before intubation) who required ventilation (MV) ≥ 24...
<h3>BACKGROUND:</h3> Although leak compensation has been widely introduced to acute care ventilators improve patient-ventilator synchronization in the presence of system leaks, there are no data on these ventilators9 ability prevent triggering and cycling asynchrony. The goal this study was evaluate during invasive noninvasive ventilation (NIV). <h3>METHODS:</h3> Using a lung simulator, impact leaks compared 7 ICU 1 dedicated NIV ventilator at 2 respiratory mechanics (COPD ARDS models)...
High-flow nasal cannula therapy (HFNC) is widely used for patients with acute respiratory failure. HFNC has a number of physiological effects. Although FIO2 considered to be constant, because an open system, varies according inspiratory flow, tidal volume (VT), and gas flow. We investigated the influence flow other parameters on during HFNC.We evaluated system and, comparison, conventional oxygen system. The apparatus was composed air/oxygen blender, heated humidifier, limb, small, medium,...
Objectives: Electrical muscle stimulation is widely used to enhance lower limb mobilization. Although upper atrophy common in critically ill patients, electrical application for the limbs has been rarely reported. The purpose of this study was investigate whether prevents and improves physical function. Design: Randomized controlled trial. Setting: Two-center, mixed medical/surgical ICU. Patients: Adult patients who were expected be mechanically ventilated greater than 48 hours stay ICU 5...
Although skeletal muscle atrophy is common in critically ill patients, biomarkers associated with have not been identified reliably. Titin a spring-like protein found muscles and has become measurable biomarker for breakdown. We hypothesized that urinary titin useful monitoring patients. Therefore, we investigated level its association Two-center, prospective observational study. Mixed medical/surgical ICU Japan. Nonsurgical adult patients who were expected to remain greater than 5 days....
Daily sedative interruption (DSI) may reduce excessive sedation and shorten the duration of mechanical ventilation. It is not clear, however, how DSI affects sleep characteristics. For patients receiving ventilation, we compared effect on quality continuous (CS). Twenty-two mechanically ventilated who were midazolam by infusion randomly assigned to two groups, (n=11) or CS (n=11). In group, sedatives interrupted until awoke expressed discomfort, after which opioids administered...
During noninvasive ventilation (NIV), leak around the mask may cause inadequate ventilatory support or patient-ventilator asynchrony such as auto-triggering. Some NIV ventilators be better than others at compensating for leak.We bench studied 3 (Vision, Carina, and Trilogy100) 2 ICU (Puritan Bennett 840 Evita XL) to assess how they coped with levels zero during NIV. With a 2-bellows-in-a-box lung model we simulated spontaneous breathing tidal volumes of 300 mL 500 mL, pressure 0 10 cm H(2)O...
Abstract Introduction Upper airway obstruction (UAO) is a major problem in unconscious subjects, making full face mask ventilation difficult. The mechanism of UAO subjects shares many similarities with that obstructive sleep apnea (OSA), especially the hypotonic upper seen during rapid eye movement sleep. Continuous positive pressure (CPAP) via nasal more effective at maintaining patency than patients OSA. We hypothesized CPAP and (nCPAP) would be (FmCPAP) for we tested our hypothesis...
In the 2014 PROtective Ventilation using HIgh versus LOw positive end-expiratory pressure (PROVHILO) trial, intraoperative low tidal volume ventilation with high (PEEP = 12 cm H2O) and lung recruitment maneuvers did not decrease postoperative pulmonary complications when compared to PEEP (0-2 approach without breaths. However, effects of on compliance remain poorly understood. We hypothesized that higher leads a dominance intratidal overdistension, whereas lower results in...
<h3>BACKGROUND:</h3> Heat and moisture exchangers (HMEs) are commonly used for humidifying respiratory gases administered to mechanically ventilated patients. While they also applied tracheostomized patients with spontaneous breathing, their performance in this role has not yet been clarified. We carried out a bench study investigate the effects of breathing parameters oxygen flow on humidification 11 HMEs. <h3>METHODS:</h3> evaluated provided by HMEs patients, system delivering high-flow...
<h3>BACKGROUND:</h3> Ventilators used for noninvasive ventilation (NIV) must be able to synchronize in the presence of system leaks. We compared ability 7 ICU ventilators and 3 dedicated NIV compensate leaks during pediatric NIV. <h3>METHODS:</h3> Using a lung simulator, we Maquet Servo-i, Dräger V500, Carina, Covidien PB840, Respironics V60, Vision, GE Healthcare/Engström Carestation, CareFusion Avea, Hamilton C3, G5 increasing (<i>n</i> = 6) decreasing 6). With simulator tested 4 leak...
<h3>BACKGROUND:</h3> High-flow nasal cannula (HFNC) therapy provides better humidification than conventional oxygen therapy. To allay loss of vapor as condensation, a servo-controlled heating wire is incorporated in the inspiratory tube, but condensation not completely avoidable. We investigated factors that might affect condensation: thermal characteristics HFNC flow, and ambient temperature. <h3>METHODS:</h3> evaluated 2 types tubes, SLH Flex 22-mm single tube RT202. Both tubes were...