A5026930330- Cardiac Ischemia and Reperfusion
- Adenosine and Purinergic Signaling
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac Fibrosis and Remodeling
- Heart Failure Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Transplantation: Methods and Outcomes
- Infective Endocarditis Diagnosis and Management
- Macrophage Migration Inhibitory Factor
- Hormonal Regulation and Hypertension
- Peripheral Artery Disease Management
- ATP Synthase and ATPases Research
- Blood Pressure and Hypertension Studies
- Cardiac tumors and thrombi
- Cardiac electrophysiology and arrhythmias
- Immune cells in cancer
Centre Hospitalier Universitaire de Tours
2016-2025
Université de Tours
2016-2025
Hospices Civils de Lyon
2010-2024
Université de Caen Normandie
2022
Institut thématique Immunologie, inflammation, infectiologie et microbiologie
2021
Thion Medical (France)
2015-2021
Hôpital Bretonneau
2020
Laboratoire CarMeN
2013-2019
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2018
Sorbonne Université
2018
Inflammation is a key factor of myocardial damage in reperfused ST-segment-elevation infarction. We hypothesized that colchicine, potent anti-inflammatory agent, may reduce infarct size (IS) and left ventricular (LV) remodeling at the acute phase infarction.In this double-blind multicenter trial, we randomly assigned patients admitted for first episode infarction referred primary percutaneous coronary intervention to receive oral colchicine (2-mg loading dose followed by 0.5 mg twice day) or...
BackgroundRecent studies have demonstrated that aldosterone levels measured in patients with heart failure or acute myocardial infarction (MI) are associated long-term mortality, but the association coronary artery disease (CAD) outside these specific settings remains unknown. In addition, no clear mechanism has been elucidated to explain observations. The present study was designed evaluate relationship between level of and risk death ischaemic events CAD a preserved left ventricular (LV)...
Background The number of patients with atrial fibrillation (AF) and cancer is rapidly increasing in clinical practice. impact on outcomes this patient population unclear, as the performance HAS‐BLED (Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs/Alcohol) CHA 2 DS ‐VASc (Congestive Heart Failure, Hypertension, Age ≥ 75 years, Diabetes Mellitus, Stroke Transient Ischemic Attack, Vascular Disease, 65 to 74 Years, Sex...
There is some uncertainty about treating patients with atrial fibrillation (AF) 1 nongender-related (NGR) stroke risk factor (CHA2DS2-VASc [ie, congestive heart failure, hypertension, age (≥75 years; 2 points), diabetes, stroke/transient ischemic attack (2 vascular disease, (65-74 years), sex (female)] score of in males and females) oral anticoagulation (OAC).We investigated adverse outcomes calculated the net clinical benefit OAC use a community-based cohort unselected AF 0 compared NGR...
Abstract Important health resources are dedicated worldwide to the management of COVID‐19. This new disease, due its large diffusion, may significantly hamper prognosis other pathologies, such as ST‐segment elevation myocardial infarction (STEMI) because (a) a possible direct negative impact and (b) shortage first response medical increased delays reperfusion. We report case 68‐year‐old man admitted for anterior STEMI asymptomatic Due extended transportation cathlab, he received intravenous...
Mitral valve replacement using a bioprosthesis remains controversial in young patients because data on long-term outcomes are missing. This study evaluated the results of PERIMOUNT pericardial mitral aged 65 years or younger. From 1984 to 2010, 148 Carpentier–Edwards bioprostheses were implanted Baseline clinical, perioperative and follow-up recorded prospectively. Structural deterioration (SVD) was defined by strict echocardiographic assessment. The mean period 8.6 ± 5.5 years, for total...
Abstract High concentrations of extracellular ATP (eATP) resulting from cell damage may be found during an ischemia/reperfusion (I/R) episode at the site injury. eATP activates purinergic receptors in dendritic cells (DCs) and inhibit inflammation. This immunosuppressive activity could interest field I/R, which is inflammatory condition involved myocardial infarction, stroke, solid organ transplantation. However, specific receptor responsible for this effect remains to identified. In study,...
Ischaemia compromises mitochondrial respiration. Consequently, the F1 Fo-ATPsynthase reverses and acts as a proton-pumping ATPase, so maintaining membrane potential (ΔΨm ), while accelerating ATP depletion cell death. Here we have looked for molecule that can selectively inhibit this activity without affecting synthesis, preserve delay ischaemic death.We developed chemoinformatic screen based on structure of BMS199264, which is reported to Fo-ATPase cardioprotective. Results suggested...
Abstract Aims The role of diuretics in patients with intermediate-risk pulmonary embolism (PE) is controversial. In this multicentre, double-blind trial, we randomly assigned normotensive PE to receive either a single 80 mg bolus furosemide or placebo. Methods and results Eligible had at least simplified Severity Index (sPESI) ≥1 right ventricular dysfunction. primary efficacy endpoint assessed 24 h after randomization included (i) absence oligo-anuria (ii) normalization all sPESI items....
Abstract Background Soluble vascular cell adhesion molecule‐1 (sVCAM‐1) is a biomarker of endothelial activation and inflammation. There still controversy as to whether it can predict clinical outcome after ST‐elevation myocardial infarction (STEMI). Our aim was assess the sVCAM‐1 kinetics evaluate its prognostic predictive value. Method We prospectively enrolled 251 consecutive STEMI patients who underwent coronary revascularization in our university hospital. Blood samples were collected...
Inflammatory processes have been identified as key mediators of ischemia-reperfusion injury in ST-segment elevation myocardial infarction (STEMI). They add damage to the myocardium and are associated with clinical adverse events (heart failure cardiovascular death) poor recovery. Colchicine is a well-known alkaloid potent anti-inflammatory properties. In proof-of-concept phase II trial, colchicine has significant 50% reduction infarct size (assessed by creatine kinase levels) comparison...