A5016944054- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Pediatric Urology and Nephrology Studies
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Genetic and Kidney Cyst Diseases
- Amoebic Infections and Treatments
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Urinary and Genital Oncology Studies
- Medical Imaging and Pathology Studies
- Parkinson's Disease Mechanisms and Treatments
- Bacteriophages and microbial interactions
- Thyroid and Parathyroid Surgery
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neurological disorders and treatments
- Cystic Fibrosis Research Advances
- Airway Management and Intubation Techniques
- Respiratory viral infections research
- Urological Disorders and Treatments
- Nosocomial Infections in ICU
- Medical Imaging Techniques and Applications
- Intensive Care Unit Cognitive Disorders
Université de Tours
2013-2025
Inserm
2015-2025
Universidad Privada del Valle
2024
Emory University
2024
Mount Sinai Medical Center
2024
Children's Healthcare of Atlanta
2024
Hospital Clínico San Carlos
2022
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2022
Centre d'Étude des Pathologies Respiratoires
2015-2021
Hospital de Sant Pau
1998-2021
High flow nasal cannula oxygen therapy (HFT) is increasingly used in intensive and emergency care departments. Patients suffering from respiratory failure, who are likely to benefit HFT, may require aerosolized bronchodilators; therefore, combining nebulization with HFT be relevant. This study aimed identify the optimal settings for implementation of within an adult circuit.We assessed mass particle size distribution aerosol emitted (inhalable mass) using mesh- jet-nebulizers placed at...
Summary Aerosol therapy in infants and toddlers is challenging. Nebulization within a nasal high flow (NHF) circuit attractive. The aim of this study was to quantify aerosol lung deposition when combined with NHF as compared standard practice. Lung doses were measured scintigraphically after nebulization jet mesh nebulizer placed spontaneously breathing non‐human primate model (macaque) the anatomical bench SAINT model, respectively representing full‐term newborn 9‐month‐old toddler. In...
There is an absence of controlled clinical data showing bronchodilation effectiveness after nebulization via nasal high-flow therapy circuits.Twenty-five patients with reversible airflow obstruction received, in a randomized order: (1) 2.5 mg albuterol delivered jet nebulizer facial mask; (2) vibrating mesh placed downstream humidification chamber (30 L/min and 37 °C); (3) without nebulization. All three conditions induced significant individual increases forced expiratory volume one second...
BACKGROUND AND PURPOSE 255: Pseudomonas aeruginosa is a main cause of ventilator-associated pneumonia (VAP) with drug-resistant bacteria. Bacteriophage therapy has experienced resurgence to compensate for the limited development novel antibiotics. However, phage compassionate use so far, resulting from lack adequate studies in relevant pharmacological models. We used pig model caused by P. that recapitulates essential features human disease study antimicrobial efficacy nebulized-phage...
Intranasal deposition of aerosols is often studied using in vitro nasal cavity models. However, the relevance these models to predict vivo human has not been validated. This study compared aerosol and a plastinated head model (NC1) its replica constructed from CT-scan (NC2).Two nebulizers (Atomisor Sonique® Easynose®) were used administer 5.6 μm (99m)Tc-DTPA seven healthy volunteers Aerosol was quantified by γ-scintigraphy nasal, upper maxillary sinus (MS) regions. The distribution...
Background: Obstructive patients may benefit from nasal high-flow (NHF) therapy, but the use of pressurized metered-dose inhalers (pMDIs) has not been evaluated in this situation. Methods: Using an adult circuit and medium-sized cannula, we have tested different NHF rates, pMDI positions, breathing patterns, spacers, spacer orientation. First, albuterol delivery at cannula outlet. The second set experiments made a nasopharyngeal cast to estimate mass potentially reaching lungs. Albuterol was...
Non-Human Primates (NHPs) are particularly relevant for preclinical studies during the development of inhaled biologics. However, aerosol inhalation in NHPs is difficult to evaluate due a low lung deposition fraction and high variability. The objective this study was influence mesh nebulizer parameters improve macaques. We developed humidified heated ventilated anatomical 3D printed macaque model upper respiratory tract reduce experiments with animals. compared vivo using 2D planar...
Background Current treatments for Alzheimer’s disease (AD) modulate global neurotransmission but are neither specific nor anatomically directed. Tailored stimulation of target nuclei will increase treatment efficacy while reducing side effects. We report the results first directional deep brain (dDBS) surgery and a patient with AD in an attempt to slow progression woman multi-domain, amnestic cognitive status. Methods aimed assess safety dDBS patients using fornix as (primary objective)...
Introduction Pre-emptive inhaled antibiotics may be effective to reduce the occurrence of ventilator-associated pneumonia among critically ill patients. Meta-analysis small sample size trials showed a favourable signal. Inhaled are associated with reduced emergence antibiotic resistant bacteria. The aim this trial is evaluate benefit 3-day course patients undergoing invasive mechanical ventilation for more than 3 days on pneumonia. Methods and analysis Academic, investigator-initiated,...
<b><i>Background:</i></b> Albeit not recommended because of contradictory results, nebulized 3% hypertonic saline is widely used for treating acute viral bronchiolitis. Whether clinical differences may be attributed to the type nebulizer has never been studied. <b><i>Objectives:</i></b> By modifying amount salt deposited into airways, characteristics might influence response. <b><i>Methods:</i></b> A prospective,...
The delivery profile of Aztreonam lysine (AZLI) during mechanical ventilation (MV) is unknown. We evaluated the amount AZLI drug delivered using an in vitro model adult MV.An lung designed to mimic current clinical practice was used. Both nebulizers were placed before a Y-piece and 4 settings tested: A) Aeroneb solo® [AS] with t-piece; B) AS spacer; C) M-Neb® [MN] t-piece D) MN spacer. Performance terms of: 1) Mass median aerodynamic diameter (MMAD); 2) Geometric standard deviation (GSD), 3)...
Abstract Objective: Children with prolonged hospital admissions for CHD often develop delirium. Antipsychotic medications (APMs) have been used to treat delirium but are known prolong the QTc duration. There is concern prolongation of interval in cardiac patients who may be more vulnerable electrocardiogram (ECG) changes and postoperative already. The goal this study was determine effect APM on duration paediatric quetiapine risperidone treating prolongation. Design: Retrospective study,...
Los trastornos del espectro autista (TEA) son afecciones neurodesarrollo, también denominadas neuropsiquiátricas heterogéneas, caracterizadas por deficiencias en la comunicación social y comportamientos repetitivos; los factores epigenéticos (FE) pieza clave su etiología; lo que neurodiversidad las neurodivergencias el TEA, se refieren a una variación natural cerebro funcionamiento neurológico difiere de considerado neurotípico. Las autismo, formas procesar mundo manera diferente términos...