A5005980997- Particle accelerators and beam dynamics
- Nuclear reactor physics and engineering
- Nuclear Physics and Applications
- Nuclear Materials and Properties
- Radiation Detection and Scintillator Technologies
- Particle Accelerators and Free-Electron Lasers
- Particle Detector Development and Performance
- Protein purification and stability
- Inhalation and Respiratory Drug Delivery
- Superconducting Materials and Applications
- Graphite, nuclear technology, radiation studies
- Dark Matter and Cosmic Phenomena
- Particle Dynamics in Fluid Flows
- Combustion and Detonation Processes
- Nuclear Engineering Thermal-Hydraulics
- Magnetic confinement fusion research
- Distributed and Parallel Computing Systems
- Particle physics theoretical and experimental studies
- Peanut Plant Research Studies
- Bioinformatics and Genomic Networks
- Microwave Engineering and Waveguides
- Drug Solubulity and Delivery Systems
- Microfluidic and Bio-sensing Technologies
- Metallurgical Processes and Thermodynamics
- Fusion materials and technologies
Institut de Physique
2009-2019
Université de Tours
2014-2019
Centre d'Étude des Pathologies Respiratoires
2014-2019
Inserm
2016-2019
Centre National de la Recherche Scientifique
1994-2015
Institut National de Physique Nucléaire et de Physique des Particules
1994-2015
Université Paris-Sud
2015
Physiopathologie et Epidémiologie des Maladies Respiratoires
2014
Université Joseph Fourier
1994-2012
French Norwegian Foundation
2011
Most monoclonal antibodies (mAbs) are administered to patients intravenously ensure high bioavailability as rapidly possible. The airways, however, an attractive delivery route for mAbs the treatment of lung diseases, making it possible increase their concentration in target organ while limiting systemic passage. Several challenges must be overcome translation into clinical practice. For example, drug and device paired efficient reliable deposition a pharmacologically active safe mAb region...
Therapeutic antibodies (Abs) are emerging as major drugs to treat respiratory diseases, and inhalation may provide substantial benefits for their delivery. Understanding the behavior of Abs after pulmonary deposition is critical development. We investigated pharmacokinetics a nebulized Ab by continuous sampling in lung parenchyma using microdialysis non-human primates. defined optimal conditions demonstrated that feasible over period several days. The concentration-profile indicated...
One of the major issues in expression profiling analysis still is to outline proper thresholds determine differential expression, while avoiding false positives. The problem being that variance inversely proportional log signal intensities. Aiming solve this issue, we describe a model, variation (EV), based on LMS method, which allows data normalization and construct confidence bands gene fitting cubic spline curves Box–Cox transformation. bands, fitted actual data, include genes devoid...
It is well-known that buried permanent-magnet synchronous machines have inductances with high-order harmonics. These inductance variations are due to nonsinusoidal field distributions and lead torque pulsations. In this paper, we use an observer estimate these The effectiveness of the proposed method investigated through computer simulations, experimental results highlight necessity consider
TOSQAN is an experimental program undertaken by the Institut de Radioprotection et Surete Nucleaire (IRSN) in order to perform thermal hydraulic containment studies. The facility a large enclosure devoted simulating typical accidental flow conditions nuclear Pressurized Water Reactor (PWR) containment. facility, which highly instrumented with non-intrusive optical diagnostics, particularly adapted safety CFD code validation (Porcheron al., 2003). present work studying interaction of water...
The PRAE project aims at creating a multidisciplinary R&D facility in the Orsay campus gathering various scientific communities involved radiobiology, subatomic physics, instrumentation and particle accelerators around an electron accelerator delivering high-performance beam with energy up to 70 MeV later 140 MeV, order perform series of unique measurements future challenging R&D. In addition will provide major education training asset for students engineers yielding regional instrument...
The determination of the beam energy in experimental hall A TJNAF (previously CEBAF) accelerator is done through a very accurate measurement field integral reference dipole magnet, electrically connected series with bending magnets transporting from to area. new method used determine integral; this described, as well calibrations laboratory. Finally, goal reach an accuracy on order 10/sup -5/ has been reached, it shown by comparing results obtained other independant methods.