A5062018098- Synthesis and biological activity
- Sphingolipid Metabolism and Signaling
- Acute Kidney Injury Research
- Melanoma and MAPK Pathways
- Protein Kinase Regulation and GTPase Signaling
- Dialysis and Renal Disease Management
- Click Chemistry and Applications
- Hippo pathway signaling and YAP/TAZ
- COVID-19 Clinical Research Studies
- Endoplasmic Reticulum Stress and Disease
- Kruppel-like factors research
- Congenital heart defects research
- Moyamoya disease diagnosis and treatment
- Wnt/β-catenin signaling in development and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Protein Tyrosine Phosphatases
- Retinal Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Angiogenesis and VEGF in Cancer
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- Cardiovascular Disease and Adiposity
- Intracranial Aneurysms: Treatment and Complications
- Retinopathy of Prematurity Studies
- Enzyme function and inhibition
Inserm
2013-2024
Université de Bordeaux
2016-2024
Centre Hospitalier Universitaire de Bordeaux
2015-2023
Biologie des maladies cardiovasculaires
2016-2023
Hôpital Pellegrin
2020-2022
Centre de Recherche en Cancérologie de Toulouse
2013-2018
Université de Toulouse
2013-2018
Université Toulouse III - Paul Sabatier
2018
Hôpital Cardiologique du Haut-Lévêque
2015
Background and objectives Prompt recognition of severe renal impairment could improve the early management critically ill patients. We compared value kinetic eGFR, plasma neutrophil gelatinase–associated lipocalin (NGAL), urine tissue inhibitor metalloproteinase-2 insulin-like growth factor–binding protein 7 ([TIMP-2]*[IGFBP7]) in predicting short-term recovery from AKI major adverse kidney events. Design, setting, participants, & measurements During 6-month study period, 245 patients were...
Coronavirus disease 2019 (COVID-19)-associated acute kidney injury (AKI) frequency, severity and characterization in critically ill patients has not been reported.
Background Hypertension is a leading cause of microvascular injury, yet the genetic determinants organ-specific vulnerability remain poorly understood. Yest, we need good mouse models to investigate complication hypertension. This study investigates role background in shaping hypertensive complications by comparing two strains with divergent inflammatory responses. Methods Three-month-old 129S1/SvlmJ and C57BL/6J mice received 600 ng/kg/min angiotensin II (AngII) or saline. We compared...
Angiogenesis involves the coordinated growth and migration of endothelial cells (ECs) toward a proangiogenic signal. The Wnt planar cell polarity (PCP) pathway, through recruitment Dishevelled (Dvl) Dvl-associated activator morphogenesis (Daam1), has been proposed to regulate actin cytoskeleton microtubule (MT) reorganization for oriented migration. Here we report that Kif26b--a kinesin--and Daam1 cooperatively initiation EC sprouting directional via MT reorganization. First, find Kif26b is...
Objective— Vessel formation requires precise orchestration of a series morphometric and molecular events controlled by multitude angiogenic factors morphogens. Wnt/frizzled signaling is required for proper vascular formation. In this study, we investigated the role Fzd7 (frizzled-7) receptor in retinal development its relationship with Wnt/β-catenin canonical pathway Notch signaling. Approach Results— Using transgenic mice, demonstrated that postnatal Endothelial cell (EC) deletion fzd7 (...
Abstract BRAF inhibitors (BRAFi) are used to treat patients with melanoma harboring the V600E mutation. However, resistance BRAFi is inevitable. Here, we identified sphingosine 1-phosphate (S1P) receptors as regulators of BRAFV600E-mutant cell-autonomous BRAFi. Moreover, our results reveal a distinct sphingolipid profile, that is, tendency for increased very long-chain ceramide species, in plasma who achieve response therapy compared progressive disease. Treatment resulted strong decrease...
While endothelial dysfunction is suggested to contribute heart failure with preserved ejection fraction pathophysiology, understanding the importance of endothelium alone, in pathogenesis diastolic abnormalities has not yet been fully elucidated. Here, we investigated consequences specific on cardiac function, independently any comorbidity or risk factor (diabetes obesity) and their potential effect cardiomyocyte.The ubiquitine ligase Pdzrn3, expressed cells (ECs), was shown destabilize...
Clinical and laboratory predictors of COVID-19 severity are now well described combined to propose mortality or scores. However, they all necessitate saturable equipment such as scanners, procedures difficult implement blood gas measures. To provide an easy fast risk score upon hospital admission, keeping in mind the above limits, we sought for a scoring system needing limited invasive data simple test co-morbidity assessment by anamnesis. A retrospective study 303 patients (203 from...
Genome-wide association studies have revealed robust associations of common genetic polymorphisms in an intron the PHACTR-1 (phosphatase and actin regulator 1) gene (chr6p24), with cervical artery dissection, spontaneous coronary fibromuscular dysplasia. The aim was to assess its role pathogenesis dissection or dysplasia.Using various tissue-specific Cre-driver mouse lines, Phactr1 deleted either endothelial cells using 2 (PDGFB [platelet-derived growth factor B]-CreERT2 mice Tie2 [tyrosine...
[Figure: see text].
Abstract Retinopathies remain major causes of visual impairment in diabetic patients and premature infants. Introduction anti‐angiogenic drugs targeting vascular endothelial growth factor (VEGF) has transformed therapy for these proliferative retinopathies. However, limitations associated with anti‐VEGF medications require to unravel new pathways vessel identify potential drug targets. Here, we investigated the role Wnt/Frizzled‐7 (Fzd7) pathway a mouse model oxygen‐induced retinopathy...
Abstract Background COVID-19-associated acute kidney injury frequency, severity and characterisation in critically ill patients has not been reported. Methods Single-center cohort performed from March 3, 2020, to April 14, 2020 4 intensive care units Bordeaux University Hospital, France. All with COVID19 pulmonary criteria were included. AKI was defined using KDIGO criteria. A systematic urinary analysis performed. The incidence, severity, clinical presentation, biological (transient vs....
NME1 (nonmetastatic expressed 1) gene, which encodes nucleoside diphosphate kinase (NDPK) A [also known as nonmetastatic clone 23 (NM23)-H1 in humans and NM23-M1 mice], is a suppressor of metastasis, but several lines evidence-mostly from plants-also implicate it the regulation oxidative stress response. Here, our aim was to investigate physiologic relevance NDPK with respect response mammals study its molecular basis. NME1-knockout mice died sooner, suffered greater hepatocyte injury, had...
Endothelial cells (ECs) are sensitive to physical forces created by blood flow, especially laminar shear stress. Among the cell responses EC polarization against flow direction emerges as a key event, particularly during development and remodeling of vascular network. adopt an elongated planar shape with asymmetrical distribution intracellular organelles along axis flow. This study aimed investigate involvement polarity via receptor ROR2 (receptor tyrosine kinase-like orphan 2) in...
In hemodialysis (HD) patients, malnutrition should be diagnosed by several assessment tools including a plasma albumin concentration of less than 3.8 g/dL or 3.5 using bromocresol green immunonephelometry (IN), respectively. However, measurement is not yet standardized and two alternative methods are also commonly used in laboratories: purple (BCP) immunoturbidimetry (IT). This study aimed to revisit the hypoalbuminemia thresholds for BCP IT, HD patients.Plasma was measured four analytical...