A5050273070- Congenital heart defects research
- Wnt/β-catenin signaling in development and cancer
- Angiogenesis and VEGF in Cancer
- Coronary Artery Anomalies
- Moyamoya disease diagnosis and treatment
- Axon Guidance and Neuronal Signaling
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Issues in Pregnancy
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipoproteins and Cardiovascular Health
- Microtubule and mitosis dynamics
- Barrier Structure and Function Studies
- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Cardiomyopathy and Myosin Studies
- Nuclear Receptors and Signaling
- Hormonal Regulation and Hypertension
- Cancer, Lipids, and Metabolism
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
Inserm
2021-2024
Université de Bordeaux
2021-2024
Biologie des maladies cardiovasculaires
2022-2024
While endothelial dysfunction is suggested to contribute heart failure with preserved ejection fraction pathophysiology, understanding the importance of endothelium alone, in pathogenesis diastolic abnormalities has not yet been fully elucidated. Here, we investigated consequences specific on cardiac function, independently any comorbidity or risk factor (diabetes obesity) and their potential effect cardiomyocyte.The ubiquitine ligase Pdzrn3, expressed cells (ECs), was shown destabilize...
Genome-wide association studies have revealed robust associations of common genetic polymorphisms in an intron the PHACTR-1 (phosphatase and actin regulator 1) gene (chr6p24), with cervical artery dissection, spontaneous coronary fibromuscular dysplasia. The aim was to assess its role pathogenesis dissection or dysplasia.Using various tissue-specific Cre-driver mouse lines, Phactr1 deleted either endothelial cells using 2 (PDGFB [platelet-derived growth factor B]-CreERT2 mice Tie2 [tyrosine...
Endothelial cells (ECs) are sensitive to physical forces created by blood flow, especially laminar shear stress. Among the cell responses EC polarization against flow direction emerges as a key event, particularly during development and remodeling of vascular network. adopt an elongated planar shape with asymmetrical distribution intracellular organelles along axis flow. This study aimed investigate involvement polarity via receptor ROR2 (receptor tyrosine kinase-like orphan 2) in...
Abstract Cerebral small vessel disease (cSVD) is a leading cause of stroke, cognitive decline and dementia, for which no specific mechanism-based treatments are available to date. Genome-wide whole-exome association studies previously identified robust associations common variants at chr17q25 with cSVD features on magnetic resonance imaging, converging bioinformatic experimental data causal involvement TRIM47 . Preliminary functional evaluation TRIM47, an ubiquitin ligase enriched in brain...
Abstract Introduction Genome-wide association studies have revealed robust associations of common genetic polymorphisms in the Phactr1 locus (6p24) (encoding Phosphatase and Actin Regulator 1) with cervico-cerebral artery dissection (CCeAD), spontaneous coronary (SCAD) fibromuscular dysplasia (FMD). These elements predisposition provide a proof concept for important shared mechanisms at molecular level between CCeAD, SCAD FMD vascular diseases. Objective Deciphering genetic, physiological...