A5042282312- Testicular diseases and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Lymphocytic Leukemia Research
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Acute Myeloid Leukemia Research
- Cancer Treatment and Pharmacology
- Hematopoietic Stem Cell Transplantation
- Hemodynamic Monitoring and Therapy
- Lung Cancer Treatments and Mutations
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Cardiovascular Function and Risk Factors
- Cancer therapeutics and mechanisms
- Sarcoma Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Acute Lymphoblastic Leukemia research
- Acute Kidney Injury Research
- Neuroendocrine Tumor Research Advances
- Traumatic Brain Injury and Neurovascular Disturbances
- Chemotherapy-induced organ toxicity mitigation
- Immunotherapy and Immune Responses
- Ovarian cancer diagnosis and treatment
Charité - Universitätsmedizin Berlin
1999-2024
University Hospital Augsburg
2023-2024
Humboldt-Universität zu Berlin
2019-2024
Freie Universität Berlin
1990-2024
Praxis für Humangenetik
2023
University Hospital Münster
2005-2021
LMU Klinikum
2012-2019
Ludwig-Maximilians-Universität München
2019
University of Lübeck
2018
University of Münster
2003-2017
<h3>Importance</h3> Optimal timing of initiation renal replacement therapy (RRT) for severe acute kidney injury (AKI) but without life-threatening indications is still unknown. <h3>Objective</h3> To determine whether early RRT in patients who are critically ill with AKI reduces 90-day all-cause mortality. <h3>Design, Setting, and Participants</h3> Single-center randomized clinical trial 231 Kidney Disease: Improving Global Outcomes (KDIGO) stage 2 (≥2 times baseline or urinary output <0.5...
Care bundles are recommended in patients at high risk for acute kidney injury (AKI), although they have not been proven to improve outcomes. We sought establish the efficacy of an implementation Kidney Disease Improving Global Outcomes (KDIGO) guidelines prevent cardiac surgery-associated AKI defined by renal biomarkers.In this single-center trial, we examined effect a "KDIGO bundle" consisting optimization volume status and hemodynamics, avoidance nephrotoxic drugs, preventing hyperglycemia...
Background Difficulties in prediction and early identification of (acute kidney injury) AKI have hindered the ability to develop preventive therapeutic measures for this syndrome. We tested hypothesis that a urine test measuring insulin-like growth factor-binding protein 7 (IGFBP7) tissue inhibitor metalloproteinases-2 (TIMP-2), both inducers G1 cell cycle arrest, key mechanism implicated acute injury (AKI), could predict cardiac surgery patients. Methods studied 50 patients at high risk...
No interventions have yet been identified to reduce the risk of acute kidney injury in setting cardiac surgery.To determine whether remote ischemic preconditioning reduces rate and severity patients undergoing surgery.In this multicenter trial, we enrolled 240 at high for injury, as by a Cleveland Clinic Foundation score 6 or higher, between August 2013 June 2014 4 hospitals Germany. We randomized them receive sham (control). All completed follow-up 30 days after surgery were analyzed...
In this prospective study, we evaluated whether high thoracic epidural anesthesia (TEA) or IV clonidine, in addition to general anesthesia, affects the cardiopulmonary bypass-and surgery-associated stress response and incidence of myocardial ischemia by their sympatholytic properties. Seventy patients scheduled for elective coronary artery bypass graft (CABG) received with sufentanil propofol. TEA was randomly induced before continued during study period 25 (anesthetized dermatomes C6-T10)....
Sepsis-associated acute renal failure is characterized by decreased GFR and tubular dysfunction. The pathogenesis of endotoxemic dysfunction with in urine concentration increased fractional sodium excretion poorly understood. This study investigated the regulation transporters during severe inflammation vivo vitro. Injection high-dosage LPS reduced BP GFR, excretion, strongly expression Na(+)/H(+)-exchanger, outer medullary potassium channel, Na(+)-K(+)-2Cl(-) co-transporter, epithelial...
Background The lack of early biomarkers for acute kidney injury (AKI) seriously inhibits the initiation preventive and therapeutic measures this syndrome in a timely manner. We tested hypothesis that insulin-like growth factor-binding protein 7 (IGFBP7) tissue inhibitor metalloproteinases-2 (TIMP-2), both inducers G1 cell cycle arrest, function as AKI after congenital heart surgery with cardiopulmonary bypass (CPB). Methods prospectively studied 51 children undergoing cardiac CPB. Serial...
Objective We aimed at validating established imaging features of idiopathic intracranial hypertension (IIH) by using state-of-the-art MR together with advanced post-processing techniques and correlated findings to clinical scores. Methods Twenty-five IIH patients as well age-, sex- body mass index (BMI)-matched controls underwent high-resolution T1w T2w in a 1.5 T scanner, followed assessment optic nerve sheaths, pituitary gland, ventricles Meckel's cave. Imaging were cerebrospinal fluid...
In patients with ischemic stroke, randomized trials showed a better functional outcome after endovascular therapy new-generation thrombectomy devices compared medical treatment, including intravenous thrombolysis. However, effects on mortality and the generalizability of results to routine clinical practice are uncertain.In prospective observational register-based study stroke treated either thrombectomy, thrombolysis, or their combination were included. Primary was modified Rankin scale...
In this prospective study, we evaluated whether high thoracic epidural anesthesia (TEA) or IV clonidine, in addition to general anesthesia, affects the cardiopulmonary bypass-and surgery-associated stress response and incidence of myocardial ischemia by their sympatholytic properties. Seventy patients scheduled for elective coronary artery bypass graft (CABG) received with sufentanil propofol. TEA was randomly induced before continued during study period 25 (anesthetized dermatomes C6-T10)....
Objective To evaluate 3D spectral domain optical coherence tomography (SDOCT) volume scans as a tool for quantification of optic nerve head (ONH) potential marker treatment effectiveness and disease progression in idiopathic intracranial hypertension (IIH). Design Patients Cross-sectional pilot trial comparing 19 IIH patients controls matched gender, age body mass index. Each participant underwent SDOCT. A custom segmentation algorithm was developed to quantify ONH (ONHV) height (ONHH)...
Whether earlier initiation of RRT in critically ill patients with AKI can improve outcomes remains debated. We examined follow-up data from a large clinical trial to prospectively investigate the long-term associated timing such patients. extended Early Versus Delayed Initiation Critically Ill Patients (ELAIN) Trial 90 days 1 year after randomization for 230 (99.6%) The primary outcome was composite major adverse kidney events (persistent renal dysfunction, dialysis dependence, and...
Abstract Background In a multicenter, randomized trial, the authors enrolled patients at high-risk for acute kidney injury as identified by Cleveland Clinic Foundation score of 6 or more. The 240 four hospitals and them to remote ischemic preconditioning control. found that reduced in undergoing cardiac surgery. now report on effects 90-day outcomes. Methods this follow-up study RenalRIP examined effect composite endpoint major adverse events consisting mortality, need renal replacement...
In Brief This study was performed to determine the secretion pattern and prognostic value of A-type (ANP) B-type (BNP) natriuretic peptide in patients undergoing cardiac surgical procedures. We measured ANP BNP coronary artery bypass grafting (CABG) with (n = 28) or without 32) ventricular dysfunction mitral 21) aortic 24) valve replacement, respectively. Postoperative mortality recorded up 730 days after operation. ANP, but not BNP, concentrations were closely associated volume reloading...
Acute renal failure (ARF) is frequently associated with polyuria and urine concentration defects it a severe complication of sepsis because increases the mortality rate. Inhibition NF-κB activation has been suggested to provide useful strategy for treatment septic shock. However, impact on sepsis-induced ARF still unclear. Therefore, we examined effect pyrrolidine dithiocarbamate (PDTC) small interfering RNA (siRNA) silencing p50/p105 downregulation vasopressin V 2 receptors aquaporin...