A5007593160- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Therapeutic Uses of Natural Elements
- Crystallization and Solubility Studies
- Renal function and acid-base balance
- Pancreatic function and diabetes
- Paleopathology and ancient diseases
- Biomedical Research and Pathophysiology
- Pancreatitis Pathology and Treatment
- Bone health and treatments
- Diabetes and associated disorders
- Alkaline Phosphatase Research Studies
- Parathyroid Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- Diet and metabolism studies
- Medical Imaging and Pathology Studies
- Building materials and conservation
- Nail Diseases and Treatments
- Adrenal Hormones and Disorders
- Neuropeptides and Animal Physiology
- Veterinary Medicine and Surgery
- Transgenic Plants and Applications
- Adipose Tissue and Metabolism
- Urological Disorders and Treatments
- Diabetes Treatment and Management
University of Freiburg
2016-2020
Spitalzentrum Centre hospitalier Biel- Bienne
1975-2019
University Medical Center Freiburg
2014
GTx (United States)
2000
Regionalspital Emmental
1975-1998
In-Q-Tel
1998
Klinik und Poliklinik für Urologie
1985-1989
University of Bern
1977-1985
Vogtland-Klinik
1983
Hôpital régional
1975-1980
1. In order to assess the relative importance of possible pathogenetic factors in formation calcium-containing renal stones, a group 18 patients (12 men, six women) with active, recurrent stone disease were compared 16 age-matched control subjects (10 given an identical diet. 2. Fifteen (83%) showed at least one, eight (44%) two, and one (6%) patient three abnormalities that might predispose formation. 3. Increased urinary calcium excretion was most common abnormality (11 patients, 61%),...
Intrauterine infection exacerbates neonatal hypoxic–ischemic (HI) brain injury and impairs the development of cerebral cortex. Here we used low-dose lipopolysaccharide (LPS) pre-exposure followed by unilateral HI insult in 7-day-old rats to study pathogenic mechanisms. We found that LPS blocked HI-induced proteolytic activity tissue-type plasminogen activator (tPA), but significantly enhanced NF-κB signaling, microglia activation, production pro-inflammatory cytokines newborn brains....
1. The short- and longer-term effects of ethane-1-hydroxy-1,1-diphosphonate (EHDP), an inhibitor crystal growth potential preventive agent against urinary tract stones in man, have been studied. 2. Measurement excretion EHDP was used to define the best dosage regimen. When 4·4 mmol given daily four divided doses concentration achieved high enough (10−5 mol/l) inhibit crystallization calcium crystals throughout day. 3. Nine patients with recurrent were this dose for 12 months seven then...
Obesity is associated with dyslipidemia and subclinical inflammation that promotes metabolic disturbances including insulin resistance pancreatic β-cell dysfunction. The nuclear protein, transcriptional regulator 1 (NUPR1) responds to cellular stresses features tissue protective properties. To characterize the role of NUPR1 in endocrine islets during inflammatory stress, we generated transgenic mice β-cell-specific Nupr1 overexpression (βNUPR1). Under normal conditions, βNUPR1 did not differ...
Mechanisms of crystal collision being the first step aggregation (AGN) were analyzed for calcium oxalate monohydrate (COM) directly produced in urine. COM was by titration urine seven healthy men, solutions urinary macromolecules and buffered distilled water (control). Crystal formation sedimentation followed a spectrophotometer scanning electron microscopy. Viscosity measured at 37 degrees C. From results, rate (v (S)), particle diffusion (D) incidences particles suspension (I (S)) (D))...
This study was designed to get information on aggregation (AGN) of urinary calcium oxalate crystals (CaOx) which seems occur in stone formation despite a protecting coat macromolecules (UMs). CaOx crystallization directly produced urine, control and albumin solution by Ox titration spectrophotometrically followed. A rapid decrease optical density indicating AGN absent 14 15 freshly voided urines 5 healthy controls. However, the presence UM-coated hydroxyapatite all with relative high sodium...
Crystal aggregation (AGN) destabilizes crystal suspensions and during crystalluria probably favors apposition to kidney calcifications preexisting stones. We analyzed inhibition of AGN stabilization calcium oxalate by urinary macromolecules (UM), urine solutions with citrate concentration.Solutions UM (UMS) were obtained a hemofiltration procedure from 6 healthy men. Calcium prepared in all adjusting Ca2+ 1.5 mM an titration 1.0 mM. Crystallization was monitored measuring optical density...