A5100437815- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Dengue and Mosquito Control Research
- Vector-borne infectious diseases
- Metabolomics and Mass Spectrometry Studies
- COVID-19 epidemiological studies
- Lymphoma Diagnosis and Treatment
- Plant Virus Research Studies
- Data-Driven Disease Surveillance
- Complement system in diseases
- Sarcoma Diagnosis and Treatment
- Respiratory viral infections research
- Malaria Research and Control
- Virology and Viral Diseases
- Diagnosis and treatment of tuberculosis
- Land Use and Ecosystem Services
- Human Mobility and Location-Based Analysis
- Viral gastroenteritis research and epidemiology
Guangdong Provincial Center for Disease Control and Prevention
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Beijing Children’s Hospital
2022-2024
Capital Medical University
2022-2024
Inner Mongolia University
2021-2022
Center for Children
2022
China Rehabilitation Research Center
2022
Australian National University
2017
During the coronavirus disease 2019 (COVID-19) pandemic, implementation of public health intervention measures have reshaped transmission patterns other infectious diseases. We aimed to analyze epidemiological characteristics dengue in Guangdong Province, China, and investigate temporal shifts epidemic Province during COVID-19 pandemic. Based on data reported cases, meteorological factors, mosquito vector density from 2012 2022, wavelet analysis was applied relationship between incidence...
Dengue fever is a severe public heath challenge in south China. A dengue outbreak was reported Chaozhou city, China 2015. Intensified interventions were implemented by the government to control epidemic. However, it still unknown degree which intensified measures reduced size of epidemics, and when should such be initiated reduce risk large outbreaks developing?We selected Xiangqiao district as study setting because majority indigenous cases (90.6%) city from this district. The numbers daily...
Tick-borne encephalitis virus (TBEV) is the most prevalent arbovirus, with a tentative estimate of 10,000 to 10,500 infections occurring in Europe and Asia every year. Endemic Northeast China, tick-borne (TBE) emerging as major threat public health, local economies tourism. The complicated array host physiological changes has hampered elucidation molecular mechanisms underlying pathogenesis this disease.System-level characterization serum metabolome lipidome adult TBEV patients healthy...
Abstract Background Due to an increase in mosquito habitats and the lack facilities carry out basic control, construction sites China are more likely experience secondary dengue fever infection after importation of initial infection, which may then number infections neighboring communities chance community transmission. The aim this study was investigate how effectively reduce transmission at communities. Methods Susceptible-Exposed-Infectious/Asymptomatic-Recovered (SEIAR) model human SEI...
As a mosquito-borne infectious disease, dengue fever (DF) has spread through tropical and subtropical regions worldwide in recent decades. Dengue forecasting is essential for enhancing the effectiveness of preventive measures. Current studies have been primarily conducted at national, sub-national, city levels, while an intra-urban fine spatial resolution still remains challenging feat. viruses rapidly because highly dynamic population flow, integrating interactions human movements between...
Plasmodium falciparum, the most lethal malaria parasite species for humans, vastly remodels mature erythrocyte host cell upon invasion its own survival. Maurer's clefts (MC) are membraneous structures established by in cytoplasm of infected cells. These organelles deemed essential trafficking virulence complex proteins. The display major protein, P. falciparum membrane protein 1 (PfEMP1) on surface red blood and subsequent cytoadhesion cells microvasculature vital organs is key mechanism...
Background: With the progress of urbanization, mobility people has gradually increased, which led to further spread dengue fever. This study evaluated transmissibility fever within districts and between different in Zhanjiang City provide corresponding advice for cross-regional prevention control. Methods: A mathematical model transmission dynamics was developed explore disease compare that regions. Results: total 467 DF cases (6.38 per 100,000 people) were reported 2018. In model, without...
The prevention and control of dengue fever (DF) has been a major public health issue in Guangdong (GD) province, China. This study aims to analyze the return period (RP) level (RL) DF epidemic GD, help formulation plan.
Tick-borne encephalitis virus (TBEV), the most prevalent arbovirus, causes potentially fatal in humans. Prevalent northeast China, tick-borne (TBE) poses a major threat to public health, local economies and tourism. There are no biomarkers for TBE, which is classified serologically clinically. Due sample heterogeneity of samples different detection platforms, obtaining stable markers great challenge metabolomics. Accurate annotation vital data mining interpretation.To identify reliable TBEV...
Abstract Background: Because of the urbanization and lack basic mosquito control facilities, constructions sites might increase transmission risk dengue. For example, outbreak in Zhanjiang Prefecture, China, 2018, started at a construction site, then spread to surrounding communities. This study aims investigate how effectively reduce dengue related sites. Methods: The was based on an fever (DF) occurred Guangdong Province 2018. We simulated virus between human mosquitoes site neighboring...
Abstract Background: Due to more mosquito habitats and the lack of basic control facilities, construction sites are likely have secondary cases after case importation, which may increase number entering community chance transmission. For example, outbreak in Zhanjiang Prefecture, China, 2018, started at a site, then occurred surrounding communities. This study aims investigate how effectively reduce dengue transmission risk related neighboring Methods: The was based on an fever (DF)...
T cell-mediated immunity plays an important role in controlling flavivirus infection, either after vaccination or natural infection. The "quality" of a cell needs to be assessed by function, and higher function is associated with more powerful immune protection. cells that can simultaneously produce two cytokines chemokines at the single-cell level are called polyfunctional (TPFs), which mediate responses through variety molecular mechanisms express degranulation markers (CD107a) secrete...
Objective To investigate the clinical features and prognostic value of childhood anaplastic large cell lymphoma(ALCL) with bone involvement. Methods The prognosis 13 ALCL patients involvement 26 without admitted to Beijing Children's Hospital Affiliated Capital Medical University from Jan.2003 May 2010 were evaluated compared retrospectively. Results Patients accounted for 33.3%(13/39 cases) enrolled in study.There 2 primary lymphoma cases, accounting 15.4% (2/13 5.1%(2/39 all...
Abstract Background: Due to more mosquito habitats and the lack of basic control facilities, construction sites are likely have secondary cases after case importation, which may increase number in neighborhood community chance transmission. This study aims investigate how effectively reduce dengue transmission neighboring communities. Methods: Susceptible-Exposed-Infectious/Asymptomatic-Recovered (SEIAR) model human SEI mosquitoes were developed estimate virus between within site a...
Tick-borne encephalitis virus (TBEV) is one of the most dangerous tick-borne viral pathogens for humans. It can cause severe (TBE), multiple neurological complications, and death. The European subtype (TBEV-Eu), Siberian (TBEV-Sib), Far-Eastern (TBEV-FE) are three main TBEV subtypes, causing varying clinical manifestations. Though TBEV-FE virulent subtype, degree variation in amino acid sequence polyprotein not high, leaving an issue without proper explanation. We performed phylogenic...
T cell-mediated immunity plays an important role in controlling flavivirus infection, either after vaccination or natural infection. The "quality" of a cell needs to be assessed by function, and higher function is associated with more powerful immune protection. cells that can simultaneously produce two cytokines chemokines at the single-cell level are called polyfunctional (TPFs), which mediate responses through variety molecular mechanisms express degranulation markers (CD107a) secrete...