A5020814711- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Sarcoma Diagnosis and Treatment
- Lysosomal Storage Disorders Research
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- CAR-T cell therapy research
- Hematological disorders and diagnostics
- Cancer Immunotherapy and Biomarkers
- Cutaneous lymphoproliferative disorders research
- Glycosylation and Glycoproteins Research
- Methemoglobinemia and Tumor Lysis Syndrome
- Multiple and Secondary Primary Cancers
- Cellular transport and secretion
- Cytomegalovirus and herpesvirus research
- Gastrointestinal Tumor Research and Treatment
- Diagnosis and treatment of tuberculosis
- Congenital Diaphragmatic Hernia Studies
- Neuroblastoma Research and Treatments
- Neonatal Health and Biochemistry
Beijing Children’s Hospital
2010-2025
Capital Medical University
2008-2025
Shandong University of Traditional Chinese Medicine
2025
Peking Union Medical College Hospital
2025
Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Center for Children
2023-2024
Ministry of Education of the People's Republic of China
2019-2024
Beijing Anzhen Hospital
2023
Summary Frequent germline mutations of HAVCR2 , recently identified in subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL), are associated with an increased risk hemophagocytic lymphohistiocytosis (HLH). However, SPTCL‐HLH represents a challenge because the difficulties treatment poor survival. Its malignant nature, specifically harbouring mutations, has also been questioned. To better understand its pathology and treatment, we analysed clinical data six patients diagnosed at our centre....
ABSTRACT Background 7‐Hydroxymethotrexate (7‐OHMTX) is the main metabolite in plasma following high‐dose MTX (HD‐MTX), which may result activity and toxicity of MTX. Moreover, 7‐OHMTX could produce crystalline‐like deposits within renal tubules under acidic conditions or induce inflammation, oxidative stress, cell apoptosis through various signaling pathways, ultimately leading to kidney damage. The objectives this study were thus explore exposure–safety relationship two compounds search...
C-MYC rearrangement has been listed as a new subcategory of B-cell acute lymphoblastic leukemia (B-ALL) in the latest International Consensus Classification (ICC), but lymphoma (B-LBL) with is extremely rare and therefore novel finding worth reporting. In this study, we described small number pediatric cases B-LBL rearrangement, which overlapped features Burkitt (BL), including highly aggressive clinical presentation, lymphoblasts precursor phenotype rearrangement; combination treatment...
Isolated central nervous system (CNS) involvement due to posttransplantation proliferative disorder (PTLD) is even rarer, with only a few cases reported in the literature. CNS patients mature B-cell non-Hodgkin's (NHL) and PTLD confers significantly worse prognosis as compared without lymphoma disease. Treatment of (CNSL) challenging resistance conventional cytotoxic intrathecal chemotherapy. Here, we report successful use rituximab two pediatric CD20 + isolated CNSL that had failed respond...
To investigate the incidence, clinical and genetic characteristics of pediatric lymphoma patients China with inborn errors immunity (IEI)-related gene mutations, which have not been fully studied.
This case report describes a patient initially diagnosed with Gaucher disease (GD) type I homozygous mutation c.1448T > C p. (Leu483Pro) at age of 2, presenting hepatosplenomegaly and cytopenia. Imiglucerase replacement therapy was initiated. At 17, bilateral hearing loss developed, subsequent Cranial MRI revealing thalamic damage, leading to reclassification as 3 GD. By 20, the presented range symptoms, including abdominal pain, diarrhea, hypoproteinemia, multiple lymphadenopathy, edema,...
Subcutaneous panniculitis T-cell lymphoma (SPTCL) is a rare, cytotoxic with which some patients have accompanying hemophagocytic syndrome (HPS). There currently no standard treatment regimen. In the past, most commonly used was multidrug chemotherapy. contrast, numerous case reports or small series suggest that immunosuppressive drugs could also be effective for patients. Since this NHL subtype extremely rare in children and adolescents, to improve understanding of disease standardize its...
To analyze the factors affecting delayed chemotherapy in children with Burkitt lymphoma (BL) and their influence on prognosis.
The aberrant expression of the anaplastic lymphoma kinase (ALK) gene in ALK-positive (ALK+) large cell (ALCL) is usually due to t(2;5)/NPM-ALK. However, rarely, ALK can also result from a rearrangement with various partner genes. Central nervous system (CNS) metastasis very rare ALK+ALCL. Patients CNS involvement show an inferior prognosis.Here, we present case 8-year-old girl diagnosed She presented fever, skin nodules, leg swelling, and abdominal pain over preceding 6 mo. had extensive...
Objective: To analyze the clinical features and prognostic factors of childhood Burkitt's lymphoma to summarize therapeutic effect mature B-cell regimen Beijing Children's Hospital. Methods: It was a retrospective study. From January 2007 December 2015, 186 patients below 18 years age with newly diagnosed, untreated were enrolled. Three cases eliminated because abandonment treatment 183 stratified treated according Hospital, groups as follows: A, n=1; B, n=59; C, n=123 97 in group C received...
Objective: To review the clinical-pathology characteristics of 19 relapsed pediatric mature B cell lymphoma and to find risk factors for recurrence feasible treatment after relapse. Method: Data 212 lymphomas cases in Beijing Children's Hospital from January 2006 June 2015 were collected retrospectively. All patients treated according regimen Hospital. During study period, relapsed; clinio-pathological before relapse analyzed retrospectively, outcomes summarized followed-up. Result: Nineteen...
Abstract Background: With current chemotherapy treatment, >90% of survival has been obtained for Burkitt lymphoma (BL). In this study, the demographic characteristics and treatment outcomes are presented 78 children in China with central nervous system-positive (CNS+) BL. Methods: This retrospective study consecutively enrolled CNS+ BL patients Beijing Children's Hospital (BCH) from 2007 to 2019 who received BCH B-cell non-Hodgkin's regimen (modified by French-American-British mature 96...
There is no guideline for the treatment of Hodgkin's lymphoma (HL) in pediatric patients with titin (TTN) gene mutation and heart failure. We explored feasibility using brentuximab vedotin (BV) plus chemotherapy without anthracyclines to treat one HL patient TTN mutation.A 5-year 7-month male was admitted hospital due high fever shortness breath. He diagnosed stage IV IVB high-risk (lymphocyte-depleted type) at admission. Echocardiography showed that left ventricular ejection fraction (LVEF)...
To evaluate the clinical characteristics of childhood lymphoblastic lymphoma (LBL) and therapeutic efficacy BCH-LBL-2003 regimen modified from BFM-90 protocol. The drug-related toxicities prognostic factors were explored at same time.From Janurary 2003 to December 2009, 112 newly diagnosed LBL patients Hematology Center Beijing Children's Hospital enrolled in this study. treated with BFM-90-LBL protocol.At a median follow-up 29 months (1 90 months), evaluated on day 33 end induction therapy....
T-cell exhaustion is one of the key reasons for attenuated cytotoxicity against tumours. At both expression and epigenetic levels, a number genes, including transcription factor TOX, are believed to be implicated in regulating exhaustion. In present study, we found that NB patients, ratio exhausted T cells, featuring upregulated PD-1 Tim-3, was increased. Meanwhile, inhibitory surface receptors, Lag-3, CD160, VISTA KLRG1, also increased, but this accompanied by reduced ability release...
Reversible posterior leukoencephalopathy syndrome (RPLS) was first described by Hinchey et al.[1] in 1996 as a clinical radiologic consisting of reversible cortical neurologic dysfunction and brain imaging findings involving the circulation, especially occipital lobes. RPLS is caused various heterogeneous factors. However, there are only few reports that have paid attention to relationship between tumor lysis (TLS) RPLS.[2] A child with Burkitt's lymphoma (BL) who developed following TLS...