A5104128004- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Metal complexes synthesis and properties
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Metal-Organic Frameworks: Synthesis and Applications
- PI3K/AKT/mTOR signaling in cancer
- Cell death mechanisms and regulation
- Steroid Chemistry and Biochemistry
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Blood Pressure and Hypertension Studies
Beijing Children’s Hospital
2022-2025
XinHua Hospital
2023-2025
Shanghai Jiao Tong University
2010-2025
Augusta University Health
2022-2024
Shanghai University of Traditional Chinese Medicine
2021-2024
Guangzhou Medical University
2022-2024
Academy of Military Medical Sciences
2024
Prevention Institute
2024
Augusta University
2006-2024
Shenzhen Pingle Orthopedic Hospital
2023
Eight free-ranging timber rattlesnakes (Crotalus horridus) from two geographically isolated Massachusetts populations were observed with skin lesions located primarily on the head but occasionally also lateral and ventral surfaces of body. The snakes underwent health assessments that included physical examination, clinical pathology, full body radiographs, thickness biopsies lesions. Each snake had fungal elements present histologically in tissue sections Ophidiomyces ophiodiicola was...
MicroRNAs (miRNAs) can bind to the 3'-untranslated regions (UTRs) of messenger RNAs, where they interfere with translation and thereby regulate cell differentiation, apoptosis tumorigenesis. Genetic polymorphisms in 3'-UTRs targeted by miRNAs alter strength miRNA binding a manner that affects behavior individual miRNAs. The histone methyltransferase SET8 has been reported methylate TP53 genomic stability. We analyzed single-nucleotide polymorphism (rs16917496) within miR-502 seed region for...
Our previous study showed that resveratrol (RSV) exhibited not only anti-tumor effect, but also had potential tumor promotion effect on pancreatic cancer (Paca) cells through up-regulation of VEGF-B. We determined whether metformin (MET) could potentiate the RSV PaCa in this study. Combination (100 μmol/l) and MET (20 mmol/l) significantly inhibited growth increased apoptosis human comparison with or alone treatment cell lines (Miapaca-2, Panc-1 Capan-2). (60 mg/kg, gavage) (250 i.p.)...
Diabetes is now generally accepted as a crucial event in the process of pancreatic cancer (PaC). However, molecular mechanisms underlying relationship between diabetes and PaC are not fully understood. Regenerating gene (REG) Ialpha growth factor affecting islet beta cells, it has been shown to be involved carcinogenesis gastrointestinal tract. It rational speculate that REG plays potential role pathogenesis with diabetes. The aim this study was evaluate protein expression profile without...
AIM:To detect the expression of sal-like protein 4 (SALL4) and to explore its relationship with clinicopathological characteristics prognosis hepatocellular carcinoma (HCC). METHODS:One hundred twenty-six samples HCC tissue, 44 adjacent noncancerous cirrhotic tissue 10 liver hemangioma were obtained from patients who underwent hepatectomy for at Fourth Hospital Hebei Medical University.None had received any form treatment before operation.After resection, all tissues fixed in 10% neutral...
<title>Abstract</title> RNA-based therapies, especially small interfering RNA (siRNA), have attracted extensive attention for tumor treatment. However, most siRNA can’t exert a therapeutic effect due to lack of targeting cells and entrapment in lysosomes upon administration. To address the challenges associated with delivery, delivery system was developed using zinc oxide nanoparticles (ZnO NPs) coated cancer cell membranes. ZnO been recognized as effective pH-responsive are widely used...
The treatment of hyperphosphatemia in children is great significance; however, there are currently very few studies investigating the use sevelamer carbonate for this condition pediatric patients. This study was conducted to compare safety and efficacy calcium combined with patients chronic kidney disease (CKD). Pediatric diagnosed CKD from March 2018 June 2023 were included study. Patients group received a combination decrease serum phosphorus levels, while or control only carbonate....
ABSTRACT Aims To investigate diabetes family involvement, including supportive and nonsupportive behaviours in China, explore the relationships among opposite forms of self‐management glycaemic control. Design A cross‐sectional study. Methods Type 2 patients were recruited from hospitals Nanjing, Shanghai Jinan, communities across between April 2023 August 2023. total 1648 completed questionnaires regarding self‐management, perceived control patient characteristics. Data analysis was...
<b><i>Background/Aims:</i></b> Although recent reports suggest that Toll-like receptor (TLR) 9 is associated with the pathogenesis of polymicrobial septic acute kidney injury (AKI), it still unclear whether and how renal TLR9 involved in development AKI. This study aimed to determine expression mouse cells related <b><i>Methods:</i></b> The efficacy small interfering RNA (siRNA) targeting was tested a cultured murine macrophage cell line...
Abstract Background Detection of programmed cell death ligand-1 (PD-L1) by immunohistochemistry (IHC) has been commonly used to predict the efficacy treatment with PD-1/PD-L1 inhibitors. However, there is limited literature regarding reliability PD-L1 testing using malignant pleural effusion (MPE) blocks. Here, we assess expression in sections from MPE blocks and evaluate value IHC double staining interpretation expression. Methods In all, 124 paired formalin-fixed tissues advanced NSCLC...
Abstract Background Chemoresistance often causes the failure of treatment and death patients with advanced non-small-cell lung cancer. However, there is still no resistance genes signature available enriched signaling derived from a comprehensive RNA-Seq data analysis cancer that could act as therapeutic target to re-sensitize acquired resistant cells chemo-drugs. Hence, in this study, we aimed identify for clinical explore regulatory mechanism. Method Analysis was conducted R studio...
Pancreatic carcinoma is an aggressive tumor that resistant to treatment regimens. Although the X-linked inhibitor of apoptosis protein (XIAP) overexpression in pancreatic cells has been previously reported, aim this study was investigate association XIAP expression with outcome. Specimens were obtained from 54 patients who underwent resection for cancer. Kaplan-Meier survival analysis used estimate post-operative survival. The results revealed a significantly shorter overall time high...
Hepatocellular carcinoma (HCC) is characterized by increased oxidative stress and the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which one main mutagenic modifications DNA stress. We analyzed association 8-OHdG with post-operative survival revealed that low levels are associated significantly shorter time. Moreover, were HCC characteristics, including tumor size, quantity, clinical staging, Child classification, portal vein thrombosis ascites. These results suggest damage a useful...
Adoptive transfer of T cell receptor-engineered cells (TCR-T) is a promising strategy for immunotherapy against solid tumors. However, the potential CD4+ in mediating tumor regression has been neglected. Nasopharyngeal cancer consistently associated with EBV. Here, to evaluate therapeutic CD4 TCR-T nasopharyngeal cancer, we screened TCRs recognizing EBV nuclear antigen 1 (EBNA1) presented by HLA-DP5. Using mass spectrometry, identified EBNA567-581, peptide naturally processed and We isolated...
Abstract The American Society of Clinical Oncology (ASCO)/College Pathologists (CAP) recently issued updated guidelines on human epidermal growth factor receptor 2 (HER2) testing by fluorescence in situ hybridization (FISH) invasive breast cancers. In this study, we aimed to investigate the impact new recommendations HER2 FISH interpretation cancers with immunohistochemically (IHC) equivocal results. 1810 cancer cases IHC results were enrolled study between January 2012 and May 2019....