A5084897374- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Eicosanoids and Hypertension Pharmacology
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Flavonoids in Medical Research
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
- Andrographolide Research and Applications
- Cancer Cells and Metastasis
- Neurological Disease Mechanisms and Treatments
- TGF-β signaling in diseases
- Amino Acid Enzymes and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Medicinal Plants and Bioactive Compounds
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
Shanghai University of Traditional Chinese Medicine
2021-2023
Shuguang Hospital
2022
Apigenin, as a natural flavonoid, has low intrinsic toxicity and potential pharmacological effects against hepatocellular carcinoma (HCC). However, the molecular mechanisms involving microRNAs (miRNAs) their target genes regulated by apigenin in treatment of HCC have not been addressed.In this study, involved prevention were explored vivo vitro using miRNA transcriptomic sequencing to determine basis for clinical applications HCC.The on proliferation, cell cycle progression, apoptosis,...
Huashi Baidu Decoction (HSBD) is a novel complex prescription which has positive effects on severe COVID-19. This study was aimed to discover key Chinese materia medica, main active compounds, hub therapeutic target proteins and core signal pathways in the potential mechanism of HSBD COVID-19 through integrating network pharmacological methods.TCMSP, TCMID STITCH databases were used screen out compounds HSBD. GeneCards database disease genes The targets construct protein-protein interaction...
Background. Alcoholic fatty liver disease (AFLD) is the first stage of alcoholic course. Yin-Chen-Hao-Tang (YCHT) has a good clinical effect on treatment AFLD, but its molecular mechanism not been elucidated. In this study, we tried to explore YCHT in improving hepatocyte steatosis AFLD mice through network pharmacology and RNA sequencing (RNA-Seq) transcriptomics. Methods. Network pharmacological methods were used analyze potential therapeutic signaling pathways targets AFLD. Then, model...
Abstract Background Chemoresistance often causes the failure of treatment and death patients with advanced non-small-cell lung cancer. However, there is still no resistance genes signature available enriched signaling derived from a comprehensive RNA-Seq data analysis cancer that could act as therapeutic target to re-sensitize acquired resistant cells chemo-drugs. Hence, in this study, we aimed identify for clinical explore regulatory mechanism. Method Analysis was conducted R studio...
Chronic alcoholic liver disease has brought great harm to human health. Alcoholic fatty is the first stage in progression of all chronic diseases. At present, there no cell model that fully matches etiology (high-fat diet + alcohol) disease. We used 100 mM ethanol +6.25 μM PA establish combined with PA-induced mouse hepatocyte AFLD (EP-AFLD model) and performed RNA-seq transcriptome sequencing. Through bioinformatics analysis comparison, we discovered EP-AFLD was more suitable for studying...
Abstract Background: Alcoholic fatty liver disease (AFLD) is the first stage of alcoholic course. Yin-Chen-Hao-Tang (YCHT) has a good clinical effect on treatment AFLD, but its molecular mechanism not been elucidated. In this study, we tried to explore YCHT in improving hepatocyte steatosis AFLD mice through network pharmacology and RNA sequencing (RNA-Seq) transcriptomics. Methods: Network pharmacological methods were used analyze potential therapeutic signaling pathways targets AFLD. Then,...
Abstract Background : Chemotherapy is the preferred approach for treatment of advanced non-small cell lung cancer (NSCLC), but it often resulted in acquired resistance, which led to failure treatment. Therefore, necessary identify and remove resistant cells tumors with resistance. Thus far, there no comprehensive analysis RNA-Seq data from patients none available enriched signaling could act as a therapeutic target re-sensitize chemo-drugs. Hence, this study, we aimed resistance signature...
Liquid chromatography tandem mass spectrometry (LC-MS/MS) is an analytical method that combines high separation of liquid with selectivity and sensitivity spectrometry. In recent years, LC-MS/MS has been widely used in clinical practice, including screening inherited disorders, determination endogenous compounds analysis biomarkers. great value to the precision prevention, diagnosis treatment some diseases due its accurate data. This article not only illustrates advantages medicine, but also...
Alcoholic fatty liver disease (AFLD) is the first stage in progression of all chronic alcoholic diseases. At present, there no cell model that fully matches etiology (high-fat diet+alcohol) human AFLD. We used 100mM ethanol+6.25μM PA to establish E+PA-induced mouse hepatocyte AFLD and performed RNA-seq transcriptome sequencing. Through bioinformatics analysis comparison, we discovered was more suitable for pathological mechanism studying than ethanol-induced model. also 208 genes were...