A5064519606- Traditional Chinese Medicine Studies
- Alcohol Consumption and Health Effects
- Advanced Glycation End Products research
- Pharmacological Effects of Natural Compounds
- Neuroblastoma Research and Treatments
- Nephrotoxicity and Medicinal Plants
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heme Oxygenase-1 and Carbon Monoxide
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Ginseng Biological Effects and Applications
- Peroxisome Proliferator-Activated Receptors
- Bioactive natural compounds
- Natural Antidiabetic Agents Studies
- Calcium signaling and nucleotide metabolism
- Amino Acid Enzymes and Metabolism
- Neonatal Respiratory Health Research
- Endoplasmic Reticulum Stress and Disease
- Mesenchymal stem cell research
Shanghai University of Traditional Chinese Medicine
2015-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2019-2024
Weatherford College
2021
Huashi Baidu Decoction (HSBD) is a novel complex prescription which has positive effects on severe COVID-19. This study was aimed to discover key Chinese materia medica, main active compounds, hub therapeutic target proteins and core signal pathways in the potential mechanism of HSBD COVID-19 through integrating network pharmacological methods.TCMSP, TCMID STITCH databases were used screen out compounds HSBD. GeneCards database disease genes The targets construct protein-protein interaction...
Panax Notoginseng flower saponins (PNFS) are the main active component of notoginseng (Burk) F. H. Chen bud (PNF) and possess significant anti-inflammatory efficacy. This study aims to explore mechanisms underlying PNFS' antiflammatory action in RAW264.7 macrophages.A cell counting kit-8 assay was used determine viability macrophages. Anti-inflammation effects PNFS lipopolysaccharide (LPS)-stimulated macrophages were measured based on detection nitric oxide (NO) overproduction (Griess...
Background. Alcoholic fatty liver disease (AFLD) is the first stage of alcoholic course. Yin-Chen-Hao-Tang (YCHT) has a good clinical effect on treatment AFLD, but its molecular mechanism not been elucidated. In this study, we tried to explore YCHT in improving hepatocyte steatosis AFLD mice through network pharmacology and RNA sequencing (RNA-Seq) transcriptomics. Methods. Network pharmacological methods were used analyze potential therapeutic signaling pathways targets AFLD. Then, model...
Abstract Background Chemoresistance often causes the failure of treatment and death patients with advanced non-small-cell lung cancer. However, there is still no resistance genes signature available enriched signaling derived from a comprehensive RNA-Seq data analysis cancer that could act as therapeutic target to re-sensitize acquired resistant cells chemo-drugs. Hence, in this study, we aimed identify for clinical explore regulatory mechanism. Method Analysis was conducted R studio...
Pulmonary fibrosis (PF) is a common clinical disease, which results in serious respiratory impairment. Xin Jia Xuan Bai Cheng Qi Decoction (XJXBCQ) traditional prescription commonly used treating lung diseases. We investigate the effect of XJXBCQ against PF and its mechanism via regulation TGF-β1/Smad vitro vivo.XJXBCQ was first extracted probed for chemical characterization. An model vivo established rats MRC-5 cells. In bleomycin (BLM)-induced model, function such as peak expiratory flow...
Abstract Lysosome membrane permeabilization (LMP) has been implicated in cell death. In the present study, we investigated relationship between death and H 2 O -/CCl 4 -induced LMP hepatocytes vitro following acute liver injury vivo . The key finding was that triggered by oxidative stress, as evidenced a suppression of LAMP1 expression, reduction LysoTracker Green AO staining leakage proton cathepsin B/D from lysosome to cytoplasm, resulting CCl also hepatocyte decreasing expression inducing...
Abstract HMGB1 is passively released by injured or dying cells and aggravates inflammatory processes. The release of calcium overload have each been reported to be important mediators H 2 O -induced injury. However, a potential connection between these two processes remains elucidated. In the present study, we employed hepatocytes investigate how takes place during cellular injury extracellular regulated this overload. addition, investigated use 58-F, flavanone extracted from Ophiopogon...
BACKGROUNDHigh mobility group box-1 (HMGB1), recognized as a representative of damageassociated molecular patterns, is released during cell injury/death, triggering the inflammatory response and ultimately resulting in tissue damage.Dozens studies have shown that HMGB1 involved certain diseases, but details on how injured hepatocytes release need to be elicited. AIMTo reveal mechanism undergoing oxidative stress.METHODS C57BL6/J male mice were fed high-fat diet for 12 wk plus single binge...
Chronic alcoholic liver disease has brought great harm to human health. Alcoholic fatty is the first stage in progression of all chronic diseases. At present, there no cell model that fully matches etiology (high-fat diet + alcohol) disease. We used 100 mM ethanol +6.25 μM PA establish combined with PA-induced mouse hepatocyte AFLD (EP-AFLD model) and performed RNA-seq transcriptome sequencing. Through bioinformatics analysis comparison, we discovered EP-AFLD was more suitable for studying...
Background Traditional Chinese Medicine Astragalus was commonly used to assist chemo-drug treatment in clinical cancer patients. However, whether injection (AGI) reverses drug resistance remains unclear. Therefore, a meta-analysis is necessary assess the effect of AGI on reversement Method The studies presenting tumor response rates patients receiving chemo-drugs combination with were systematically searched from six common scientific databases until February 2024. relative risks (RRs)...
Abstract Background Acquired chemo-drug resistance constantly led to the failure of chemotherapy for malignant cancers, consequently causing cancer relapse. Hence, identifying biomarker drug in is vital improve treatment efficacy. The clinical prognostic value CYP24A1 remains conclusive, we aim evaluate association between and patients through a meta-analysis approach. Method Relevant studies detecting expression or SNP up till May 2022 were systematically searched four common scientific...
Abstract Background : Chemotherapy is the preferred approach for treatment of advanced non-small cell lung cancer (NSCLC), but it often resulted in acquired resistance, which led to failure treatment. Therefore, necessary identify and remove resistant cells tumors with resistance. Thus far, there no comprehensive analysis RNA-Seq data from patients none available enriched signaling could act as a therapeutic target re-sensitize chemo-drugs. Hence, this study, we aimed resistance signature...
Alcoholic fatty liver disease (AFLD) is the first stage in progression of all chronic alcoholic diseases. At present, there no cell model that fully matches etiology (high-fat diet+alcohol) human AFLD. We used 100mM ethanol+6.25μM PA to establish E+PA-induced mouse hepatocyte AFLD and performed RNA-seq transcriptome sequencing. Through bioinformatics analysis comparison, we discovered was more suitable for pathological mechanism studying than ethanol-induced model. also 208 genes were...