A5102893612- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- MicroRNA in disease regulation
- Folate and B Vitamins Research
- Pleural and Pulmonary Diseases
- Advanced biosensing and bioanalysis techniques
- Pneumonia and Respiratory Infections
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Biocrusts and Microbial Ecology
- Graphene and Nanomaterials Applications
- Algal biology and biofuel production
- Genetic Associations and Epidemiology
- Vascular Tumors and Angiosarcomas
- Vascular Malformations and Hemangiomas
- Extracellular vesicles in disease
- Drug Transport and Resistance Mechanisms
- Glycosylation and Glycoproteins Research
- vaccines and immunoinformatics approaches
- CRISPR and Genetic Engineering
- Helicobacter pylori-related gastroenterology studies
- Monoclonal and Polyclonal Antibodies Research
Capital Medical University
2016-2025
The University of Tokyo
1997-2025
Capital University
2025
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2025
Fuzhou University
2024
Henan Provincial People's Hospital
2024
Fourth Affiliated Hospital of Harbin Medical University
2024
Chinese Center For Disease Control and Prevention
2020-2024
Nanjing Drum Tower Hospital
2018-2024
Beijing Chest Hospital
2015-2024
Tuberculosis (TB) has been the leading lethal infectious disease worldwide since 2014, and about one third of world's population latent TB infection (LTBI). It is largely attributed to difficulties in diagnosis treatment LTBI patients. Exosomes offer a new perspective on investigation process infection. In this study, we performed small RNA sequencing explore profiles serum exosomes derived from patients healthy controls (HC). Our results revealed distinct miRNA profile three groups. We...
Glycosylation significantly affects protein structure and function thus participates in multiple physiologic pathologic processes. Studies demonstrated that immunoglobulin G (IgG) N-glycosylation associates with the risk factors of ischemic stroke (IS), such as aging, obesity, dyslipidemia, type 2 diabetes, hypertension. The study aimed to investigate association between IgG IS a Chinese population. glycome composition patients (n = 78) cerebral arterial stenosis (CAS) 75) controls 77) were...
Background: Cancer-associated fibroblasts (CAFs) have been shown to be among the most prominent cells in tumor microenvironment and play a significant role accelerating metastasis by interacting with other type of cells. Tumor-associated macrophages (TAMs), predominant tumor-infiltrating immune cells, also important roles cancer progression. Here, we aimed evaluate effects CAFs on infiltration TAMs lymphatic triple-negative breast (TNBC). Material methods: The study included 278 patients...
Graphene oxide (GO) has attracted intensive interest in biological and medical fields recent years due to its unique physical, chemical, properties. In our previous work, we proved that GO could deliver small interfering RNA (siRNA) into cells downregulate the expression of desired gene.This study investigated potential a modified nanocarrier for co-delivery siRNA doxorubicin (DOX) enhanced cancer therapy. Fourier transform infrared spectroscopy, laser particle size analyzer, UV-visible gel...
Adiponectin and resistin have been linked to inflammation, endothelial dysfunction, and/or insulin secretion or resistance. It remains be elucidated which of these adipokines is associated primarily with biomarkers all only some categories, i.e. insulinemia.We studied 1065 healthy women, Nurses' Health Study participants, who provided blood samples in 1989-1990. A cross-sectional analysis was conducted assess the relationships between total high-molecular weight (HMW) adiponectin...
Background Health care workers (HCWs) are at risk of latent tuberculosis infection (LTBI). In China, (TB) is a major public health problem, but the prevalence LTBI in HCWs especially hospital for pulmonary diseases has not been assessed enough. The aim this study was to determine and putative factors among chest TB research institute China. Methodology/Principal Findings A cross-sectional conducted China 2012. by T-SPOT.TB, information on collected using standardised questionnaire. Risk were...
Next-generation (postgenomic) biomarkers from the nascent field of glycomics now offer fresh vistas for innovation in chronic disease and system diagnostics clinical medicine. Our previous work has shown an association between hypertension immunoglobulin G (IgG) glycome composition, suggesting that individual variation N-glycosylation IgG might contribute to pathogenesis. The present study examined, first time best our knowledge, N-glycans as potential Kazakh population. profile 60...
Nostopeptins A and B were isolated from the cultured freshwater cyanobacterium Nostoc minutum (NIES-26). Their structures elucidated on basis of 2D NMR data chemical degradation. These cyclic depsipeptides containing Ahp (3-amino-6-hydroxy-2-piperidone) inhibited elastase chymotrypsin potently.
The lack of effective differential diagnostic methods for active tuberculosis (TB) and latent infection (LTBI) is still an obstacle TB control. Furthermore, the molecular mechanism behind progression from LTBI to has been not elucidated. Therefore, we performed label-free quantitative proteomics identify plasma biomarkers discriminating pulmonary (PTB) LTBI. A total 31 overlapping proteins with significant difference in expression level were identified PTB patients (n = 15), compared...
A successful siRNA delivery system is dependent on the development of a good carrier. Graphene oxide (GO) has gained great attention as promising nanocarrier in recent years. It been reported that GO could be used to deliver series drugs including synthetic compounds, proteins, antibodies, and genes. Our previous research indicated functionalized into tumor cells induce gene silencing effect, follow up research, this GO-R8/cRGDfV(GRcR) was designed prepared for VEGF-siRNA novel The Zeta...
Circular RNAs (circRNAs) may serve as biomarkers for a potentially non-invasive diagnosis of cancer. To understand their diagnostic performance, systematic meta-analysis the published literature was conducted to review efficiency circRNAs in patients with Eligible studies up November 30, 2017, on PubMed and EMBASE, were selected meta-analysis. All carefully independently reviewed by two researchers based titles abstracts, following which full texts perused potential eligibility. statistical...
Background: Epidemiological studies observing inconsistent associations of telomere length (TL) with ischemic stroke (IS) are susceptible to bias according reverse causation and residual confounding. We aimed assess the causal association between TL, IS, subtypes including large artery (LAS), small vessel (SVS), cardioembolic (CES) by performing a series two-sample Mendelian randomization (MR) approaches. Methods: Seven single nucleotide polymorphisms (SNPs) were involved as candidate...
Tuberculous meningitis (TBM) is the most common and severe form of central nervous system tuberculosis. Due to non-specific clinical presentation lack efficient diagnosis methods, it difficult discriminate TBM from other frequent types meningitis, especially viral (VM). In order identify potential biomarkers for discriminating VM reveal different pathophysiological processes between VM, a genome-wide miRNA screening PBMCs TBM, healthy controls (HCs) using microarray assay was performed (12...
The early identification of heart failure (HF) risk may favorably affect outcomes, and the combination multiple biomarkers provide a more comprehensive valuable means for improving stratification. This study was conducted to assess importance individual cardiac creatine kinase MB isoenzyme (CK-MB), B-type natriuretic peptide (BNP), galectin-3 (Gal-3) soluble suppression tumorigenicity-2 (sST2) HF diagnosis, predictive performance these four analyzed using random forest algorithms.A total 193...
Atherosclerosis (AS) is an important causative agent of cardiovascular diseases, and the occurrence development AS accompanied by oxidative stress, so antioxidant therapy has become one strategies for treatment AS. This study aimed to design construct apolipoprotein ApoA1-modified inorganic-organic composite nanosystem therapy, in which ApoA1 was modified onto carboxylated CeO2/Mn3O4 covalent bonding, resulting nanocomplex with a structure similar that high-density lipoprotein. The could...
Abstract In the tumor immunosuppressive microenvironment (TIME), regulatory T cells (Tregs) critically suppress anticancer immunity, characterized by high expression of glucocorticoid‐induced TNF receptor (GITR) and sensitivity to reactive oxygen species (ROS). This study develops a near‐infrared (NIR)‐responsive hollow nanocomplex (HPDA‐OPC/DTA‐1) using polydopamine nanoparticles (HPDA), endowed with thermogenic antioxidative properties, specifically targeting Tregs activate antitumor...
<title>Abstract</title> RNA-based therapies, especially small interfering RNA (siRNA), have attracted extensive attention for tumor treatment. However, most siRNA can’t exert a therapeutic effect due to lack of targeting cells and entrapment in lysosomes upon administration. To address the challenges associated with delivery, delivery system was developed using zinc oxide nanoparticles (ZnO NPs) coated cancer cell membranes. ZnO been recognized as effective pH-responsive are widely used...
Modular megasynthases, such as polyketide synthases (PKSs) and non‐ribosomal peptide synthetases (NRPSs), are molecular assembly lines that biosynthesize many pharmaceutically ecologically important natural products. Understanding how these compounds evolve could inspire the artificial evolution of compound diversity by metabolic engineering. Over past two decades, a number seminal studies have significantly contributed to our understanding product evolution. However, NRPS PKS remains poorly...
Modular megasynthases, such as polyketide synthases (PKSs) and non‐ribosomal peptide synthetases (NRPSs), are molecular assembly lines that biosynthesize many pharmaceutically ecologically important natural products. Understanding how these compounds evolve could inspire the artificial evolution of compound diversity by metabolic engineering. Over past two decades, a number seminal studies have significantly contributed to our understanding product evolution. However, NRPS PKS remains poorly...