A5036624578- Respiratory viral infections research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Viral gastroenteritis research and epidemiology
- Tracheal and airway disorders
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Neuroscience of respiration and sleep
- Respiratory and Cough-Related Research
- Cytokine Signaling Pathways and Interactions
- Virus-based gene therapy research
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Allergic Rhinitis and Sensitization
- Obstructive Sleep Apnea Research
- Antimicrobial Peptides and Activities
- Viral Infections and Immunology Research
- RNA and protein synthesis mechanisms
- Microbial infections and disease research
- SARS-CoV-2 and COVID-19 Research
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2016-2025
Wenzhou Medical University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Capital Medical University
2022
Center for Children
2022
Academy of Medical Sciences
2022
Beijing Children’s Hospital
2022
Weatherford College
2014
Yueqing People's Hospital
2009
Taizhou First People's Hospital
2006
Curcumin, a natural product derived from the plant Curcuma longa, has been found to have anti-inflammatory, antineoplastic and antifibrosis effects. It reported that curcumin attenuates allergic airway inflammation in mice through inhibiting NF-κB its downstream transcription factor GATA3. also proved effect of down-regulating Notch1 receptor nuclear levels. In this study, we aimed investigate anti-inflammatory on acute asthma underlying mechanisms. 36 male BALB/c were randomly divided into...
Abstract Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants and hyperoxia exposure major cause. In hyperoxic injury animal model, alveolar simplification pro-inflammatory cells infiltration are the main pathophysiologic changes. Caffeine drug used to treat apnea infants. Early use of caffeine can decrease rate severity BPD while mechanisms still unclear. The purpose this study was evaluate effects on inflammation development neonatal mice with...
A total of 171 Streptococcus pneumoniae isolates causing invasive disease were isolated from Chinese children. The serotype distribution and antimicrobial resistance tested. results suggested that the 7-valent pneumococcal conjugate vaccine has a preventive effect among children there should be long-term surveillance for 19A.
Asthma is characterized by chronic inflammation, and long-term inflammation leads to airway remodeling. But the potential regulatory mechanism of remodeling not clearly understood, there still no effective way prevent Present studies have confirmed role microRNAs (miRNAs) in development disease, which known as suppressing translation or degradation messenger RNA (mRNA) at posttranscriptional stage. In this study, we described miRNA-133a asthma demonstrated it regulating through...
Dear Editor, Coronaviruses (CoVs) have a broad spectrum in humans and other animals, causing asymptomatic infections or respiratory tract infections, gastroenteritis, neurological diseases of varying severity 1-3 .CoVs are the largest known RNA viruses, belonging to family Coronaviridae 4 .On basis serology genome phylogeny, CoVs divided into four genera named Alpha-, Beta-, Delta-, Gamma-coronavirus 5,6 .To date, six human coronaviruses (HCoVs) been identified, including two α-CoVs...
Human adenovirus (HAdV) is a common pathogen in children with acute respiratory infections (ARIs). The aim was to describe the epidemiology, molecular, and clinical characteristics of HAdV among hospitalized ARIs Wenzhou southeastern China.From January 2018 December 2019, nasopharyngeal swab or sputum specimens were prospectively collected from ARIs. detected using direct immunofluorescence. We used multiplex PCR assay combined capillary electrophoresis targeting hexon gene's hypervariable...
T helper 17 (Th17) cells play an important role in the pathogenesis of allergic asthma. Th17 cell differentiation requires Notch signaling. γ ‐Secretase inhibitor (GSI) blocks signaling; thus, it may be considered as a potential treatment for The aim this study was to evaluate effect GSI on mouse model OVA used induce asthma presence and absence GSI. ameliorated development OVA‐induced asthma, including suppressing airway inflammation responses reducing severity clinical signs. also...
Notch signaling pathway is critically involved in the differentiation of T helper (Th) cells, key players pathogenesis allergic diseases.The study to explore whether Th17/Treg dysregulation children with asthma (AA) associated alteration expression.Thirty-five patients AA and thirty-five healthy control were selected. Flow cytometry was used detect Th17 Treg cells. Quantitative real-time polymerase chain reaction (QRT-PCR) measure expression Notch1 mRNA. The correlations among mRNA...
To identify the variations in fusion (F) protein gene of RSV China, a molecular epidemiological study was conducted. A total 553 positive specimens were collected from 2338 pediatric patients hospitalized with community-acquired pneumonia during multi-center conducted 2014-2016. 252 samples (183 A, 69 B) selected for F sequencing, and analyzed together 142 sequences downloaded GenBank. The result showed that all Chinese B strains could be divided respectively into three branches. Compared...
ABSTRACT Human parainfluenza viruses (HPIVs) are a significant cause of acute lower respiratory tract infections (ALRTIs) among young children and elderly individuals worldwide. The four types HPIVs (HPIV1–4) can recurrent pose economic burden on health care systems globally. However, owing to the limited availability complete genome sequences, genetic evolution these development vaccines antiviral treatments hampered. To address this issue, study utilized next-generation sequencing obtain...
Dexibuprofen is the pharmacologically active enantiomer of ibuprofen. However, its application as an antipyretic in children with fever caused by upper respiratory tract infection (URTI) requires more evidence. This study aimed to compare effect between dexibuprofen and ibuprofen URTI. Totally, 281 subjects were randomly assigned (N = 142) or 139) group at a 1:1 ratio. The administered + mimetic solution 1-4 times per day. was considered least effective if lower limit 95% confidence interval...
Objective: To investigate the predominant genotypes and epidemiological characteristics of human adenovirus (HAdV) in pediatric community-acquired pneumonia (CAP) China. Methods: This was a repeated cross sectional study. Between November 2014 2016, nasopharyngeal aspirates (NPAs) or throat swabs from each hospitalized patients diagnosed as CAP 12 hospitals Northern Southern China were collected. Respiratory specimens screened for 18 respiratory viruses including HAdV by using Luminex xTAG...
The study was aimed to examine the effect of chronic intermittent hypoxia (CIH) on spatial memory growing rats and explore possible underlying mechanisms. Sixty two were trained perform 8-arm radial maze task divided into four groups: 2-week-CIH (2IH), 2-week-control (2C), 4-week-CIH (4IH) 4-week-control (4C). There more reference errors, working errors total in 2IH 4IH groups compared controls. levels 8-iso-Prostaglandin F(2-alpha) [8-ISO-PGF(2-alpha)], an vivo marker for oxidative stress,...