A5102823973- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Trauma and Emergency Care Studies
- Complementary and Alternative Medicine Studies
- Neonatal Respiratory Health Research
- Venous Thromboembolism Diagnosis and Management
- Cancer Cells and Metastasis
- Computational Drug Discovery Methods
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Mechanical Circulatory Support Devices
- Gallbladder and Bile Duct Disorders
- Bone fractures and treatments
- Urban Transport and Accessibility
- Chemokine receptors and signaling
- Pharmacological Effects of Natural Compounds
- Human-Automation Interaction and Safety
- Thyroid Cancer Diagnosis and Treatment
- Nosocomial Infections in ICU
- Cardiac Arrest and Resuscitation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Kidney Disease and Diabetes
- Vitamin K Research Studies
- Traffic and Road Safety
- Lymphatic System and Diseases
Shanghai Sixth People's Hospital
2011-2024
Shanghai Jiao Tong University
2014-2022
Shanghai Ninth People's Hospital
2017
Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis.
Colorectal cancer (CRC) is one of the most common cancers worldwide, with a particularly high incidence in developed countries. Distant metastasis and recurrence are main causes CRC-related deaths. MicroRNAs (miRNAs) serum make them potential biomarkers for cancers, as reported or tumor tissues from CRC patients. In this study, we found that miR-612 expression was significantly lower cells compared peritumor normal cells, metastatic specimens non-metastatic specimens, whereas AKT2 exhibited...
Abstract Chemokine and the chemokine receptor have a key role in tumor progress. Here, we supposed that CCR 7 might induce invasion, migration, epithelial–mesenchymal transition ( EMT ) process of breast cancer. In this research, human cancer MCF ‐7 MDA ‐ MB ‐231cells were treated with CCL 19 small‐interfering RNA si for activation inhibition 7, respectively. Cell invasion transwell assays used to detect effect on migration. The results demonstrated mediated cell migration by inducing ,...
Abstract Vulnerable road users (pedestrians, bicyclists, and motorcyclists) account for an increasing proportion of traffic injuries. We used a case-crossover study design to examine the association between cell-phone usage injuries among pedestrians, electric bicycle riders during course their travel. studied 643 bike riders, aged 10–35 years who were involved in injury, visited emergency department one 3 hospitals Shanghai, China, 2019, owned cell phone. Half participants (n = 323; 50.2%)...
A body of experimental evidence suggests that the female sex is associated with a lower risk mortality after trauma-hemorrhage. However, controversy remains regarding mechanism responsible for these differences and if basic science findings correspond to clinical differences. Racial disparities in trauma outcomes have also been increasingly described. Until now, research on association between patient mainly focused patients Europe United States. Our attempted determine whether survival...
Sepsis, a life-threatening clinical syndrome, is leading cause of mortality after experiencing multiple traumas. Once diagnosed with sepsis, patients should be given an appropriate empiric antimicrobial treatment followed by the specific antibiotic therapy based on blood culture due to its rapid progression tissue damage and organ failure. In this study, we aimed analyze risk factors outcome sepsis in traumatic investigate performance metagenomic next-generation sequencing (mNGS) compared...
As a multifaceted syndrome, sepsis leads to high risk of death worldwide. It is difficult be intervened due insufficient biomarkers and potential targets. The reason that regulatory mechanisms during are poorly understood. In this study, expression profiles from GSE134347 were integrated construct gene interaction network through weighted co-expression analysis (WGCNA). R package DiffCorr was utilized evaluate differential correlations identify significant differences between healthy...
Aims Thyroid hormones widely affect the cardiovascular system, but effects of mild thyroid dysfunction on clinical prognosis patients with acute ST segment elevation myocardial infarction (STEMI) remains unclear. Our aims were to analyze relations between at admission and outcomes in Chinese STEMI. Methods A total 1,176 STEMI available data function follow-up analyzed, including 348 [subclinical hypothyroidism (n=81), hyperthyroidism (SHyper) (n=51), low triiodothyronine syndrome (LT3S)...
Abstract Aims/Introduction Microalbuminuria is positively related to metabolic syndrome (MetS). Our aim was investigate whether urinary albumin‐to‐creatinine ratio ( UACR ) within the normal range independently associated with MetS in Chinese community‐based patients type 2 diabetes. Materials and Methods A total of 514 participants (206 males 308 females; mean age 66 years) less than 3.5 mg/mmol were enrolled from two downtown areas Shanghai. The stratified into quartiles according levels....
This study was designed to clarify biological changes of cranial base synchondrosis chondrocytes (CBSCs) upon cyclic tensile strain (CTS) loading which simulated orthopaedic mechanical protraction on synchondroses (CBS).A two-step digestion method used isolate CBSCs obtained from 1-week-old Sprague Dawley rats. Immunohistochemical staining type II collagen and Sox9 conducted identify chondrocytes. A CTS 1 Hz 10% elongation applied the second passage by FX-5000™ Tension System for 24 hours....
Abstract Background Pyogenic liver abscess(PLA)is a potentially life-threatening disease associated with elevated risk of morbidity and mortality. Ultrasound or CT-guided percutaneous catheter drainage (PCD) needle aspiration (PNA) are important surgical methods for the treatment PLA. While their comparative efficacy is still debated, aim study was to compare PCD PNA in abscesses. Methods Taking retrospective approach, 172 patients abscesses from Shanghai Sixth People's Hospital, Jiaotong...
Objective To observe the clinic effect of pulmicort repuls inhalation acute exacerbation chronic obstructive pulmonary disease(AECOPD). Methods 92 patients with AECOPD were randomly divided into two groups:the observed group 50 given treatment budesonide (1 mg)inhalation foggy twice a day, control 42 injection methylprednisolone(40 mg)a day. Record result PaO2,PaCO2,pH,HCO3 on seventh day,meanwhile clinical symptoms as well side effect. Results The rate efficiency was 48. 00%. while 23. 81%,...
Abstract Patients with atrial fibrillation (AF) have a higher risk of ischemic stroke. However, it is still unknown whether acute (AAF) in the emergency department can affect outcomes stroke (AIS) patients. In this study, and prognosis AIS patients AFF were assessed total 706 identified patients, who grouped based on their AF history. Logistic regression showed that age ≥ 73 (OR: 2.00; 95% CI: 1.18–3.37; p = 0.010), baseline NIHSS score 1.18; 1.15–1.22; < 0.001), AAF onset 1.87;...