A5055986456- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Cancer-related gene regulation
- Endometriosis Research and Treatment
- Lymphoma Diagnosis and Treatment
- RNA Research and Splicing
- Pregnancy and Medication Impact
- Genomic variations and chromosomal abnormalities
- Immune Cell Function and Interaction
- Lipid metabolism and disorders
- Ectopic Pregnancy Diagnosis and Management
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- Atherosclerosis and Cardiovascular Diseases
- Galectins and Cancer Biology
- T-cell and Retrovirus Studies
- COVID-19 Impact on Reproduction
- Pregnancy-related medical research
- CAR-T cell therapy research
- Gynecological conditions and treatments
- Prenatal Screening and Diagnostics
- Cancer Genomics and Diagnostics
Third Affiliated Hospital of Southern Medical University
2024-2025
Shenzhen Second People's Hospital
2024
Shenzhen University Health Science Center
2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
Sun Yat-sen University
2022-2024
Key Laboratory of Guangdong Province
2024
Reproductive Science Medical Center
2024
National Clinical Research Center for Digestive Diseases
2023
Abstract m 5 C is one of the longest-known RNA modifications, however, its developmental dynamics, functions, and evolution in mRNAs remain largely unknown. Here, we generate quantitative mRNA maps at different stages development 6 vertebrate invertebrate species find convergent unexpected massive methylation maternal mediated by NSUN2 NSUN6. Using Drosophila as a model, reveal that embryos lacking undergo cell cycle delays fail to timely initiate maternal-to-zygotic transition, implying...
Embryo implantation, a crucial step in human reproduction, is tightly controlled by estrogen and progesterone (P 4 ) via receptor alpha (PGR), respectively. Here, we report that N 6 -methyladenosine (m A), the most abundant mRNA modification eukaryotes, plays an essential role embryo implantation through maintenance of P signaling. Conditional deletion methyltransferase-like 3 ( Mettl3 ), encoding m A writer METTL3, female reproductive tract using Cre mouse line with Pgr promoter Pgr-Cre...
Abstract Epstein-Barr virus (EBV) related post-transplant lymphoproliferative disorder (EBV-PTLD) is a life-threatening complication after hematopoietic stem cell transplantation (HSCT) or solid organ (SOT), for which no standard therapeutic means have been developed. Significant increase expression of natural killer group 2 member D ligands (NKG2DLs) was observed on B-lymphoblastoid cells EBV-PTLD, indicating NKG2DLs as potential targets treatment EBV-PTLD. In this study, the recombinant...
This cohort study investigates the association between COVID-19 vaccination status and artificial insemination by partner outcomes among couples experiencing infertility in China.
Nymphaea candida Presl (NC), traditionally used in medicine for heat syndrome-related ailments, possesses antioxidative, anti-inflammatory, hepatoprotective, and neuroprotective properties. This research investigates the antidepressant effects mechanisms of ethyl acetate (NCEA). Primary components NCEA were identified as phenolic acids flavonoids through UPLC-MS/MS analysis. The depression mouse model was induced via intracerebroventricular injection Lipopolysaccharide (LPS), followed by...
Introduction Human brucellosis, a Brucella infection caused most common zoonosis in the world, remains serious public health burden China. chronic always causes immunosuppressive status and results severe organ or tissue damages. The aim of this work was to study role myeloid-derived suppressor cells (MDSCs) human brucellosis. Methods Fifty cases brucellosis 40 healthy individual controls were enrolled study. We analyzed frequency subsets MDSCs PBMC between control groups by flow cytometry....
Introduction Previous observational studies have shown that polycystic ovary syndrome (PCOS) was associated with adverse pregnancy and perinatal outcomes. However, it remains controversial whether PCOS is an essential risk factor for these We aimed to use instrumental variables in a two-sample Mendelian randomization (MR) study determine causality between Materials methods Summary statistics were extracted from recent genome-wide association (GWAS) meta-analysis conducted PCOS, which...
ABSTRACT Objective To investigate whether serum progesterone (P4) levels on embryo transfer (ET) day correlate with the likelihood of live birth in artificial frozen–thawed cycles using intramuscular progesterone. Design Retrospective cohort study. Setting University‐affiliated hospital. Population Patients undergoing single euploid blastocyst after preimplantation genetic testing. Methods Live rate (LBR) was calculated each percentile P4 to detect a threshold associated an increased...
Abstract Problem The impact of antibiotic‐cured chronic endometritis (CE) on perinatal outcomes patients conceived with frozen embryo transfer (FET) was unclear. Method This study to re‐evaluate the a cohort infertile who had undergone endometrial biopsy for CE detection from February 2018 December 2019 and successfully delivered babies after FET. population divided into two groups: non‐CE (NCE) group (0‐4/HPF CD138) cured‐CE (CCE) (CD138+/HPF≥5 has been cured one or rounds antibiotic...