A5028865772- RNA regulation and disease
- Viral Infections and Immunology Research
- Parasitic Infections and Diagnostics
- Parasitic infections in humans and animals
- Climate Change, Adaptation, Migration
- CRISPR and Genetic Engineering
- Viral Infections and Vectors
- Cancer-related gene regulation
- Mosquito-borne diseases and control
- Leptospirosis research and findings
- RNA Research and Splicing
- interferon and immune responses
- RNA modifications and cancer
BGI Group (China)
2025
BGI Research
2024-2025
Botswana Geoscience Institute
2024
Sun Yat-sen University
2021-2022
Abstract m 5 C is one of the longest-known RNA modifications, however, its developmental dynamics, functions, and evolution in mRNAs remain largely unknown. Here, we generate quantitative mRNA maps at different stages development 6 vertebrate invertebrate species find convergent unexpected massive methylation maternal mediated by NSUN2 NSUN6. Using Drosophila as a model, reveal that embryos lacking undergo cell cycle delays fail to timely initiate maternal-to-zygotic transition, implying...
Upon SARS-CoV-2 infection, viral intermediates specifically activate the IFN response through MDA5-mediated sensing and accordingly induce ADAR1 p150 expression, which might lead to A-to-I RNA editing. Here, we developed an virus-specific editing identification pipeline, surveyed 7622 RNA-seq data from diverse types of samples infected with SARS-CoV-2, constructed atlas sites in SARS-CoV-2. We found that was dynamically regulated, varied between tissue cell types, correlated intensity innate...
Abstract Alveolar echinococcosis (AE) is caused by the chronic infection of E. multilocularis , whose tumor‐like growth can lead to high fatality if improperly treated. The early diagnosis and treatment advanced AE remain challenging. Herein, bulk RNA‐seq, scRNA‐seq, spatial transcriptomics technologies are integrated, reveal host immune response mechanism against both spatially chronologically, collecting mouse liver samples at multiple timepoints up 15 months post infection. These results...
The cellular and molecular mechanisms underlying the neuropathology of Japanese encephalitis virus (JEV) remain obscure. Herein, we designed Stereo-seq chips to simultaneously capture in situ transcriptomes both host JEV, constructing a comprehensive spatiotemporal pathological landscape for (JE). This study reveals central role vascular system JE pathogenesis, particularly meninges, which displayed strongest signal inflammation cell death JEV-infected brain. activation Ackr1+ endothelial...
ABSTRACT Alveolar echinococcosis (AE) is caused by the invasive growth of metacestodes Echinococcus multilocularis ( E. ). The early diagnosis, management, and treatment AE remains challenging. Herein, we integrated bulk RNA-seq, scRNA-seq, ST technologies to reveal immune characteristics both spatially chronologically in infected mouse liver. An unprecedented high-resolution spatial atlas infection foci was obtained, revealing pivotal role neutrophils, Spp1 + monocyte-derived macrophages...
Abstract Upon SARS-CoV-2 infection, viral intermediates activate the Type I interferon (IFN) response through MDA5-mediated sensing and accordingly induce ADAR1 p150 expression, which might lead to A-to-I RNA editing of SARS-CoV-2. Here, we developed an virus-specific identification pipeline, surveyed 7622 RNA-seq data from diverse types samples infected with SARS-CoV-2, constructed atlas sites in We found that was dynamically regulated, on average, approximately 91 events were deposited at...