A5108048994- RNA modifications and cancer
- Bone Tissue Engineering Materials
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Robotics and Sensor-Based Localization
- Spinal Fractures and Fixation Techniques
- Hemostasis and retained surgical items
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Hip and Femur Fractures
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Advanced Vision and Imaging
- Nanoparticle-Based Drug Delivery
- Surgical Sutures and Adhesives
- Cancer-related molecular mechanisms research
- Hydrogels: synthesis, properties, applications
- Medical Imaging and Analysis
- Robotic Path Planning Algorithms
- Magnesium Alloys: Properties and Applications
- Periodontal Regeneration and Treatments
- RNA Research and Splicing
Cornell University
2023-2025
Weill Cornell Medicine
2023-2025
Chinese PLA General Hospital
2015-2024
Harbin Institute of Technology
2021-2024
Sun Yat-sen University
2017-2023
Shenzhen Institute of Information Technology
2023
Guidewire (United States)
2022
Cytoskeleton (United States)
2022
Sun Yat-sen Memorial Hospital
2020
People's Liberation Army No. 150 Hospital
2019
Medical sealant devices for in vivo hemostasis are far from satisfactory the aged society. A major challenge is effective integration of quick hemorrhage control increased anticoagulated patients, high safety, and facile accessibility. Here, a well-defined ammonolysis-based Tetra-PEG hydrogel developed with rapid gelation speed, strong tissue adhesion, mechanical strength. Introduction cyclized succinyl ester groups into matrix endows fast degradable controllably dissolvable properties. The...
Immediate hemorrhage control and infection prevention are pivotal for saving lives in critical situations such as battlefields, natural disasters, traffic accidents, so on. In situ hydrogels promising candidates, but their mechanical strength is often not strong enough use situations. this study, we constructed three with different amounts of Schiff-base moieties from 4-arm-PEG-NH2, 4-arm-PEG-NHS, 4-arm-PEG-CHO which vancomycin was incorporated an antimicrobial agent. The possess porous...
Death happening due to massive hemorrhage has been involved in military conflicts, traffic accidents, and surgical injuries of various human disasters. Achieving rapid effective hemostasis save lives is crucial urgent bleeding situations. Herein, a covalent cross-linked AG-PEG glue based on extracellular matrix-like amino-gelatin (AG) PEG derivatives developed. The gelatinizes fast exhibits firm indiscriminate close adhesion with moist tissues upon being dosed. formed establishes an adhesive...
Abstract m 5 C is one of the longest-known RNA modifications, however, its developmental dynamics, functions, and evolution in mRNAs remain largely unknown. Here, we generate quantitative mRNA maps at different stages development 6 vertebrate invertebrate species find convergent unexpected massive methylation maternal mediated by NSUN2 NSUN6. Using Drosophila as a model, reveal that embryos lacking undergo cell cycle delays fail to timely initiate maternal-to-zygotic transition, implying...
The objective of this study was to evaluate the effectiveness treatment infected nonunion tibia and femur by bone transport. We retrospectively reviewed 110 patients with treated Our included 92 males 18 females a mean age 38.90 years. site involved 72 tibias 38 femurs. length defects after radical debridement 6.15 cm (range 3–13 cm). follow-up removal apparatus 23.12 months (14–46 months). Ten including seven three were lost follow-up. All achieved union, no recurrence infection observed....
Adenosine-to-inosine (A-to-I) RNA editing regulates miRNA biogenesis and function. To date, fewer than 160 sites have been identified. Here, we present a quantitative atlas of A-to-I through the profiling 201 pri-miRNA samples 4694 mature in human, mouse, Drosophila. We identified 4162 ∼80% pri-miRNAs 574 miRNAs. is prevalent many tissue types human. However, high-level mostly found neuronal tissues mouse Drosophila . Interestingly, edited miRNAs non-neuronal human gain two distinct sets new...
Abstract mRNA m5C, which has recently been implicated in the regulation of mobility, metabolism and translation, plays important regulatory roles various biological events. Two types m5C sites are found mRNAs. Type I sites, contain a downstream G-rich triplet motif computationally predicted to be located at 5′ end putative hairpin structures, methylated by NSUN2. II UCCA loops structures. However, their biogenesis remains unknown. Here we identified NSUN6, methyltransferase that is known...
Tissue-engineered scaffolds are an effective method for the treatment of bone defects, and their structure function essential regeneration. Digital light processing (DLP) printing technology has been widely used in tissue engineering (BTE) due to its high resolution gentle process. As commonly bioinks, synthetic polymers such as polyethylene glycol diacrylate (PEGDA) Pluronic F127 (F127DA) have satisfactory printability mechanical properties but usually lack sufficient adhesion cells...
ABSTRACT Alpha-ketoglutarate-dependent dioxygenase, also known as fat mass and obesity-associated protein (FTO), is an RNA demethylase that mediates the demethylation of N 6 ,2-O-dimethyladenosine (m6Am) -methyladenosine (m6A). Both m6Am m6A are prevalent modifications in mRNA affect different aspects transcript biology, including splicing, nuclear export, translation efficiency, degradation. The role FTO during (herpes) virus infection remains largely unexplored. In this study, we show UL13...
In recent years, hydroxyapatite (HAp) and β-tricalcium phosphate (TCP) were extensively used to prepare composite scaffolds for bone repair. However, due a lack of systematical evaluation HAp TCP repair, their distinctions on regeneration in vivo have not been clearly clarified date. this study, we constructed poly(lactic-co-glycolic acid) (PLGA) with the same contents similar structures porosities, systematically investigated performance repair rabbits' calvarial defects. The HAp/PLGA...
N 6 ,2’- O -dimethyladenosine (m Am) is a modified nucleotide located at the first transcribed position in mRNA and snRNA that essential for diverse physiological processes. m Am mapping methods assume each gene uses single start nucleotide. However, transcription usually involves multiple sites, generating numerous 5’ isoforms. Thus, gene-level annotations cannot capture diversity of modification transcriptome. Here, we describe CROWN-seq, which simultaneously identifies transcription-start...
Minimally invasive surgery has become popular because of the lower incidence wound complications. However, achieving an anatomic reduction that provides a satisfactory outcome is difficult using minimally surgery. Our study aimed to evaluate and clinical outcomes closed percutaneous fixation treatment traction device for displaced intra-articular calcaneal fractures compared with traditional open plate extended lateral approach.A total 40 patients 45 feet calcaneus from 2012 2016 were...
N 6 ,2’- O -dimethyladenosine (m Am) is a modified nucleotide located at the first transcribed position in mRNA and snRNA that essential for diverse physiological processes. m Am mapping methods assume each gene uses single start nucleotide. However, transcription usually involves multiple sites, generating numerous 5’ isoforms. Thus, levels annotations cannot capture diversity of modification transcriptome. Here we describe CROWN-seq, which simultaneously identifies transcription-start...
The treatment of bone defect after tumor resection is a great challenge for orthopedic surgeons. It should consider that not only to inhibit growth and recurrence, but also repair the preserve limb function. Hence, it necessary find an ideal functional biomaterial can defects inactivate tumor. Magnetic nanoparticles (MNPs) have its unique advantages achieve targeted hyperthermia avoid damage surrounding normal tissues promote osteoblastic activity formation. Based on previous stage, we...