A5055473059- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Fibroblast Growth Factor Research
- Immune cells in cancer
- Diagnosis and Treatment of Venous Diseases
- 3D Printing in Biomedical Research
- Immunotherapy and Immune Responses
- Innovative Microfluidic and Catalytic Techniques Innovation
- Ultrasound and Hyperthermia Applications
- Nanoparticles: synthesis and applications
- Gut microbiota and health
- Thermal properties of materials
- Transplantation: Methods and Outcomes
- Immune Cell Function and Interaction
- Microfluidic and Capillary Electrophoresis Applications
- Wound Healing and Treatments
- Diet and metabolism studies
- Nanopore and Nanochannel Transport Studies
- Cancer Immunotherapy and Biomarkers
- Bioactive Compounds and Antitumor Agents
Huazhong University of Science and Technology
2020-2025
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2020-2025
Union Hospital
2020-2025
The University of Texas MD Anderson Cancer Center
2025
Union Hospital
2020-2023
Wuhan Union Hospital
2020-2021
Oxidative damage is a critical cause of diabetic wounds. Exosomes from various stem cells could promote wound repair. Here, we investigated the potential mechanism by which exosomes adipose-derived (ADSC-EXOs) healing through modulation oxidative stress. We found that ADSC-EXOs proliferation, migration, and angiogenesis in keratinocytes, fibroblasts, endothelial cells. Furthermore, reduced reactive oxygen species (ROS) levels these protected them against hypoxic stress damage. Finally, local...
Abstract Background Tumor cell-derived exosomes (TEx) have emerged as promising nanocarriers for drug delivery. Noninvasive multimodality imaging tracing the in vivo trafficking of TEx may accelerate their clinical translation. In this study, we developed a TEx-based nanoprobe via hydrophobic insertion mechanism and evaluated its performance dual single-photon emission computed tomography (SPECT) near-infrared fluorescence (NIRF) colon cancer. Results were successfully isolated from HCT116...
Colon cancer contributes to high mortality rates as the result of incomplete resection in tumor surgery. Multimodal imaging can provide preoperative evaluation and intraoperative image-guiding. As biocompatible nanocarriers, extracellular vesicles hold great promise for multimodal imaging. In this study, we aim synthesized an vesicles-based nanoprobe visualize colon with positron-emission tomography/computed tomography (PET/CT) near-infrared fluorescence (NIRF) imaging, investigated its...
Abstract Background Cancer stem cells (CSCs) are crucial for the growth, metastasis, drug resistance, recurrence, and spread of tumors. Napabucasin (NAP) could effectively inhibit CSC, but its mechanism has not been fully explained. Additionally, NAP also drawbacks poor water solubility low utilization. Therefore, this study only elaborated new inhibiting CSCs, built NAP-loaded nanoprobes using apoptotic tumor-derived microparticles (TMPs) as carriers to combine diagnose treat colon cancer...
Abstract Introduction: Immune checkpoint inhibitors fail to control most PDAC tumors. Identifying novel ways enhance immunotherapy in is highly desired. This study aimed evaluate a new phenformin analogue, termed Re-Phen, that targeted intratumoral dysregulated metabolism pathways. Methods: Re-Phen was encapsulated into polymeric micellar give MRP. 99mTc-Phen, structurally matched radiotheranostic counterpart of also synthesized and micelles (i.e. 99mTc-MRP) for SPECT/CT imaging...
Multimodal image-guided photothermal therapy (PTT) has great application potential in cancer treatment due to its advantages of low side effects and good efficacy. There is an urgent need for PTT nanocarriers with high loading efficiency modified surfaces. Goat milk-derived extracellular vesicles (GMVs) ideal nanoplatforms their anti-inflammatory ability, tumor retention yield, biosafety. This study used GMVs design a theranostic nanoprobe positron emission tomography/computer...
Pharmacokinetics of parallel or comparison samples can be imaged simultaneously with a mini PET scanner-based microfluidic radiobioassay system.
In the healthy gut mucosa, epithelial cells lining lumen experience low oxygen levels, typically less than 2%, referred to as physiological hypoxia or physioxia. This gradient is maintained by diffusion of from blood vessels along crypt-villus axis, creating varying degrees within mucosal lining. Physiological at surface regulates innate immunity enhancing barrier function and modulating resident immune cells. However, studies suggest that inflammatory diseases involve hypoxia, exacerbated...
Abstract BackgroudColon cancer contributes to high mortality rates as the result of incomplete resection in tumor surgery. Multimodal imaging can provide preoperative evaluation and intraoperative image-guiding. As biocompatible nanocarriers, extracellular vesicles hold great promise for multimodal imaging. In this study, we aim synthesized an vesicles-based nanoprobe visualize colon with positron-emission tomography/computed tomography (PET/CT) near-infrared fluorescence (NIRF) imaging,...
Abstract Purpose Photodynamic therapy (PDT) is a promising cancer treatment strategy with rapid progress in preclinical and clinical settings. However, limited external light penetration precise delivery of photosensitizers hamper its translation. As such, the internal source such as Cerenkov luminescence (CL) from decaying radioisotopes offers new opportunities. Herein, we show that goat milk-derived extracellular vesicles (GEV) can act carrier to deliver photosensitizer Chlorin e6 (Ce6)...