A5017011396- Signaling Pathways in Disease
- Immune Response and Inflammation
- Heat shock proteins research
- Electrolyte and hormonal disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Pharmacological Effects and Toxicity Studies
- Phagocytosis and Immune Regulation
- Bladder and Urothelial Cancer Treatments
- Biochemical Acid Research Studies
- SARS-CoV-2 and COVID-19 Research
- Wound Healing and Treatments
- Salivary Gland Disorders and Functions
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Endoplasmic Reticulum Stress and Disease
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
- Urinary and Genital Oncology Studies
- ATP Synthase and ATPases Research
- Immune cells in cancer
- Immune Cell Function and Interaction
- Parasitic Infections and Diagnostics
- Selenium in Biological Systems
- Autophagy in Disease and Therapy
- Liver Disease and Transplantation
Mansoura University
2018-2021
University of Cincinnati
2020-2021
University of Cincinnati Medical Center
2019-2021
Mansoura University Hospital
2018
University of Würzburg
2014-2016
University of Plymouth
2016
Peninsula Health
2016
Comprehensive Cancer Center Mainfranken
2014
The current work aimed to synthesize selenium and zinc nanoparticles using the aqueous extract of Ephedra aphylla as a valuable medicinal plant. prepared were characterized by TEM, zeta potential, changes in phytochemical constituents. Hence, phenolic, flavonoid, tannin contents reduced case samples than original values extract. its showed high potency antioxidant agents result DPPH• assay. assessed anticancer against six tumor cells normal lung fibroblast (WI-38) cell line. revealed very...
Abstract Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to mice induces skin inflammation that exhibits many aspects psoriasis, an inflammatory human disease. Here we show depleted B cells or bearing interleukin (IL)-10-deficient a fulminant upon IMQ exposure, whereas ablation NFATc1 in results suppression Aldara-induced inflammation. In vitro , proliferation and IL-10 expression by is blocked BCR signals inducing NFATc1. By binding HDAC1,...
Alternatively activated (M2) macrophages promote wound healing but weaken antimicrobial defenses. The mechanisms that enforce macrophage divergence and dictate the phenotypic metabolic characteristics of M2 remain elusive. We show alternative activation with interleukin (IL)-4 induces expression metallothionein 3 (MT3) regulates polarization function. MT3 was requisite for reprograming in IL-4-stimulated or M(IL-4) to mitochondrial respiration suppress glycolysis. fostered an phenotype,...
Regulatory B cells (Bregs) are unique subpopulations of with immune-regulating or immune-suppressing properties and play a role in peripheral tolerance. Due to the current limitations human Breg studies among periodontal diseases, present study, we tried analyze change circulating Bregs, pro-inflammatory, anti-inflammatory cytokines patients periodontitis. Peripheral blood from 55 stage 2 periodontitis 20 healthy controls was analyzed using flow cytometry evaluate frequency CD19+CD24+CD38+...
In peripheral lymphocytes, the transcription factors (TFs) NF-κB, NFAT, and AP-1 are prime targets of signals that emerge from immune receptors. Upon activation, these TFs induce gene networks orchestrate growth, expansion, effector function lymphocytes. NFAT NF-κB share several properties, such as a similar mode induction architecture in their DNA-binding domain, there is subgroup κB-like DNA promoter motifs bound by both types TFs. However, unlike interact collaborate binding to DNA, seem...
Sodium valproate (VPA) is an antiepileptic drug (AED) licensed for epilepsy and used during pregnancy in various indications. Alpha-lipoic acid (ALA) a natural compound inducing endogenous antioxidant production. Our study aimed to investigate the effect of prenatal administration VPA on pancreas rat offspring assess potential protective role ALA co-administration pregnancy.Twenty-eight pregnant female albino rats were divided into four groups: group I (negative control), II (positive...
Hepatocellular carcinoma (HCC) is the commonest primary liver neoplasm that usually develop in background of cirrhosis. Hepatitis C virus endemic Egypt and major cause Studying characteristics patients with HCC may help clarifying schedule for screening high-risk an early detection HCC. The 492 attending hepatology clinics Specialized Medical Hospital, Mansoura University follow up cirrhois were subjected to full history, physical examination, laboratory profile, imaging studies needed...
Background and aim: CD10 is expressed in urothelial carcinoma cells cancer associated fibroblasts (CAF). In the current study, immunohistochemical staining (IHC) mRNA expression of bladder (UCB) were assessed, its relationship with tumor progression prognosis was investigated. Patients Methods: this 106 formalin fixed paraffin-embedded (FFPE) tissue UCB, obtained through radical cystectomy specimen, 10 matched normal samples included.CD10 evaluated by immunohistochemistry real time PCR...
Abstract Histoplasma capsulatum (Hc) is a dimorphic fungus that affected by environmental temperature. Hc distributed worldwide. When inhaled, the microconidia and spores reach lung are converted to pathogenic yeast phase within phagosomes of macrophages. The replicates intracellularly until these phagocytes activated cytokines, typically from T cells. Excluding iron, effect trace metals on interaction with innate immune cells has been inadequately studied. cells’ metabolic processes...