A5017891095- Cancer-related molecular mechanisms research
- Pharmacological Effects and Toxicity Studies
- MicroRNA in disease regulation
- Apelin-related biomedical research
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Cholesterol and Lipid Metabolism
- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- ATP Synthase and ATPases Research
- Epilepsy research and treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Regulation of Appetite and Obesity
- Nigella sativa pharmacological applications
- Biochemical and Molecular Research
- Heat shock proteins research
- Dye analysis and toxicity
- Vitamin C and Antioxidants Research
- Vitamin K Research Studies
- Neonatal and Maternal Infections
- Dietary Effects on Health
- Circular RNAs in diseases
- Immune Response and Inflammation
- Vibrio bacteria research studies
Damietta University
2024
Mansoura University
2017-2024
Sultan Qaboos University
2021
Objectives: To study the possible anti-seizure and neuroprotective effect of glucagon like peptide 1 (GLP1) analogue (liraglutide) in a pentylenetetrazole (PTZ) induced kindled rat model its underlying mechanisms. Methods: Thirty Sprague Dawley rats were allocated into 3 equal groups; i) Normal group: normal received saline, ii) PTZ (kindling) (50 mg/Kg intraperitoneally (i.p.)) every other day for 2 weeks iii) + GLP1 same as group but liraglutide (75 µg/kg i.p. daily) before injection....
Abstract Toll-like receptor (TLR) family signature has been implicated in sepsis etiopathology. We aimed to evaluate the genetic profile of TLR pathway-related key genes; myeloid differentiation protein 88 ( MYD88 ), IL1 receptor-associated kinase 1 IRAK1 nuclear factor kappa-B1 NFKB1 and interleukin 6 IL6 ) blood neonates with at time admission post-treatment for available paired-samples. This case–control study included 124 infants admitted neonatal intensive care unit 17 controls. The...
Valproic acid (VPA) is a powerful antiepileptic drug that was associated with several neurological and hepatic problems especially increasing its dose duration. These may be metabolic in origin related to glucose homeostasis. So, the present study investigated effect of different doses durations VPA on expression transporters (Glut1 Glut4), oxidative stress inflammatory cytokine (IL-6) liver specific brain regions. Seventy-two male Sprague-Dawley rats were randomly allocated into three equal...
Small non-coding RNAs (microRNAs) have been evolved to master numerous cellular processes. Genetic variants within microRNA seed region might influence biogenesis and function. The study aimed at determining the role of microRNA-499 (MIR-499) gene family polymorphism as a marker for susceptibility progression bronchial asthma analyze structural functional impact rs3746444 region. Genotyping 192 participants (96 patients 96 controls) in discovery phase 319 subjects (115 204 replication was...
The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide dismutase [SOD] glutathione [GSH]), expression heat shock protein (Hsp) 70 connexin 43 (Cx-43) in muscles isoproterenol (ISO) induced infarction (MI). Thirty two adult male Sprague Dawely rats were divided into 4 groups (each 8 rats): normal control (NC) group, ISO...
Nutritional overload in the form of high‐fat and nonglycolysis sugar intake contributes towards accelerated creation reactive oxygen species (ROS), hyperglycemia, dyslipidemia. Glucose absorption its subsequent oxidation processes fat muscle tissues alter as a consequence these modifications. Insulin resistance (IR) caused glucose transporter 4 (GLUT4) translocation to encounter challenge that manifested itself changes glycolytic pathways insulin signaling. We previously found beta ( β...
The aim of the current work was to clarify modulation role green tea extract (GTE) over structural and functional affection thyroid gland after long term use lithium carbonate (LC). suggested underlying mechanisms participating in were researched.Twenty-four Sprague-Dawley adult albino rats included work. They divided into three groups (control, LC, concomitant LC + GTE). sustained for 8 weeks. Biochemical assays performed (thyroid hormone profile, interleukin 6 [Il-6]). Histological,...
Aging is a naturally occurring physiological process with deleterious impact on various body organs and humans’ well-being. The aging population increasing worldwide, which imposes the need for exploration of nutritional options that can intercept processed organs. Vitamin K2 (VK2) fat-soluble vitamin emerging evidence its therapeutic merits. In current study, natural induced significant liver deterioration disrupted Keap-1/Nrf-2/HO-1 axis increased COX-2, iNOS TNF-α expression apoptotic...
Alopecia areata (AA) is a type of immune-mediated alopecia. Recent studies have suggested microRNAs’ (miRNAs) implication in several cellular processes, including epidermal and hair follicle biology. Single nucleotide polymorphisms (SNPs) can modify gene expression levels, which may induce an autoimmune response. This case−control study included 480 participants (240 for each case/control group). MicroRNA-34a (MIR-34A) rs2666433A/G variant was genotyped using real-time allelic discrimination...
Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal aggressive courses treatment. Transcriptional reprogramming stem cell-like state could explain some deregulated molecular signatures in GBM disease. The present study aimed quantify expression profiling longevity-related transcriptional factors SOX2, OCT3/4, NANOG evaluate their diagnostic performance values...
Background: Kidney diseases are one of the most common disorders modern life. Cadmium (Cd)-induced kidney damage is a cause chronic renal failure. Several mechanisms have been postulated to explain underlying Cd induced injury such as oxidative stress, apoptosis and autophagy. The aim present study was examine effect ghrelin(AG) on by possible Methods: Thirty male Sprague Dawley rats were subdivided into 3 equal groups; Group I (control) vehicle control, II (Cd) group in which subjected 5 mg...