A5027744247- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Moyamoya disease diagnosis and treatment
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Stroke Rehabilitation and Recovery
- Neurological Disease Mechanisms and Treatments
- Meningioma and schwannoma management
- Dementia and Cognitive Impairment Research
- Cerebrospinal fluid and hydrocephalus
- Meat and Animal Product Quality
- Nutritional Studies and Diet
- Neurological Disorders and Treatments
- Peripheral Artery Disease Management
- Cerebrovascular and genetic disorders
- Aortic aneurysm repair treatments
- Glioma Diagnosis and Treatment
University of Oxford
2010-2022
Creative Commons
2021
Nuffield Orthopaedic Centre
2011-2019
John Radcliffe Hospital
2007-2016
Mayo Clinic
2012
St Mary's Hospital
2012
Royal Hallamshire Hospital
2012
Sunnybrook Health Science Centre
2012
Health Sciences Centre
2012
St. Mary's Medical Center
2012
BackgroundOur aim was to assess the long-term risks of death, disability, and rebleeding in patients randomly assigned clipping or endovascular coiling after rupture an intracranial aneurysm follow-up International Subarachnoid Aneurysm Trial (ISAT).Methods2143 with ruptured aneurysms were enrolled between 1994 2002 at 43 neurosurgical centres coiling. Clinical outcomes 1 year have been previously reported. All UK some non-UK continued 2004 original cohort. Annual has done for a minimum 6...
Background and Purpose— Because the long-term security of endovascular treatments remains uncertain, a follow-up study patients treated in International Subarachnoid Aneurysm Trial was performed to compare frequency, timing, consequences aneurysm recurrence. Methods— Patient data were reclassified by actual treatment performed. patient characteristics, including occlusion grades, time type retreatment, clinical outcomes, compared. The relationship between these variables late retreatment as...
Background and Purpose— We report the primary outcome of Cerecyte Coil Trial, a randomized trial to determine whether polymer-loaded coils compared with Micrus bare platinum improved proportion patients angiographic occlusion aneurysm at 6 months when assessed by core laboratory. The secondary objectives were compare clinical outcomes retreatment rates in 2 groups. Methods— Five hundred between 18 70 years age ruptured or unruptured target be treated either 23 centers worldwide. Two...
Aneurysmal subarachnoid haemorrhage (aSAH) is a devastating event with substantial case-fatality. Our purpose was to examine which clinical and neuro-imaging characteristics, available on admission, predict 60 day case-fatality in aSAH evaluate performance of our prediction model. We performed secondary analysis patients enrolled the International Subarachnoid Aneurysm Trial (ISAT), randomised multicentre trial compare coiling clipping patients. Multivariable logistic regression used develop...
The International Subarachnoid Aneurysm Trial (ISAT) reported that endovascular coiling yields better clinical outcomes than surgical clipping at 1 year. high cost of the consumables associated with procedure (particularly coils) led health care purchasers to conclude was a more costly overall. To examine this assumption and provide evidence for future policy, accurate comprehensive data are required on overall resource usage each strategy.We detailed results patient treatment pathways,...
The aim of this study was to determine the probability seizures after treatment a ruptured cerebral aneurysm by clip occlusion and coil embolization, identify risks predictors over short- long-term follow-up period.The population included 2143 patients with intracranial aneurysms who were enrolled in 43 centers randomly assigned application or placement. Those suffering seizure identified prospectively at various time points randomization, as follows: before treatment; discharge; discharge 1...
This study arose from a need to systematically evaluate the clinical and angiographic outcomes of intracranial aneurysms treated with modified coils. We report procedural safety in prospective randomized controlled trial endovascular coiling for ruptured unruptured aneurysms, comparing polymer-loaded Cerecyte coils bare platinum 23 centers worldwide.Five hundred patients between 18 70 years age or target aneurysm planning undergo were receive Analysis was by intention treat.Two forty-nine...
OBJECTIVE In this study, the authors examined trends in population-based hospital admission rates, patient-level case fatality rates (CFRs), and mortality for nontraumatic (spontaneous) subarachnoid hemorrhage (SAH) England. METHODS Population-based data (59,599 people admitted to a with SAH, 1999-2010; 37,836 whose death certificates mentioned 1995-2010) were analyzed. RESULTS Hospital SAH per million population declined by 18.3%, from 100.4 (95% CI 97.6-103.1) 1999 82.0 79.7-84.4) 2010....
<h3>BACKGROUND AND PURPOSE:</h3> Independent evaluation of angiographic images is becoming widely applied in the assessment treatment outcomes cerebral aneurysms. In current study, we assessed agreement between an independent core laboratory and operators regarding appearance a recent randomized, controlled trial. <h3>MATERIALS METHODS:</h3> Data were derived from Cerecyte Coil Trial. Angiographic each coiled aneurysm, taken immediately after embolization at 5- to 7-month follow-up,...
<h3>BACKGROUND AND PURPOSE:</h3> Anterior communicating artery aneurysms account for one-fourth of all intracranial and frequently occur in the context A1 vessel asymmetry. The purpose this study was to correlate circle Willis anatomic variation association angiographic clinical outcomes anterior aneurysm coiling. <h3>MATERIALS METHODS:</h3> Cerecyte Coil Trial provides a subgroup 124 cases with after endovascular One hundred seventeen had complete imaging follow-up outcome analysis,...
Previous analyses of the International Subarachnoid Aneurysm Trial (ISAT) cohort have reported on clinical outcomes after treatment a ruptured intracranial aneurysm with either neurosurgical clipping or endovascular coiling.To evaluate long-term quality-adjusted life years (QALYs) gained coiling compare to in UK ISAT.Between September 12, 1994 and May 1, 2002, patients aneurysms who were assumed equipoise randomly allocated coiling. We followed-up 1644 22 centers for minimum 10 yr....
Background and Purpose— ISAT (International Subarachnoid Aneurysm Trial) demonstrated that 1 year after aneurysmal subarachnoid hemorrhage, coiling resulted in a significantly better clinical outcome than clipping. After 5 years, this difference did not reach statistical significance, but mortality was still higher the clipping group. Here, we present additional analyses, reporting excluding pretreatment deaths. Methods— Outcome measures were death with or without dependency at years...
Aneurysmal subarachnoid haemorrhage (aSAH) is a devastating event with frequently disabling outcome. Our aim was to develop prognostic model predict an ordinal clinical outcome at two months in patients aSAH. We studied enrolled the International Subarachnoid Aneurysm Trial (ISAT), randomized multicentre trial compare coiling and clipping aSAH patients. Several models were explored estimate patient's according modified Rankin Scale (mRS) after final validated internally bootstrapping...
Purpose To report the discharge and 6 month clinical outcomes in patients treated with Cerecyte or bare platinum coils a prospective randomized trial. Material methods 500 were enrolled trial, 23 centers worldwide. 263 for previously unruptured aneurysm 234 recently ruptured who grade 1 2 after subarachnoid hemorrhage (SAH). A secondary outcome of trial was to collect any differences between allocated groups. This methodology allowed investigators examine accurately, large multicenter...
Purpose To report the 6 month angiographic results in patients treated with Cerecyte or bare platinum coils a prospective randomized trial. Materials and methods 500 undergoing coil treatment of ruptured unruptured cerebral aneurysm 23 centers Europe, North America Japan were randomly assigned to receive either Coils coils. The primary objective was determine if improved outcome on follow-up digital angiography months after treatment. Angiographic also obtained at 12–24 enrollment. Imaging...
Hua, Xinyang PhD; Gray, Alastair Wolstenholme, Jane Clarke, Philip Molyneux, Andrew J FRCR; Kerr, Richard S C FRCS; Alison BA; Sneade, Mary Rivero-Arias, Oliver DPhil Author Information
Purpose: Limited literature is available on the natural history of stroke cohort eligible for mechanical thrombectomy. Reported herein are data in a but untreated by thrombectomy and ineligible or refractory to IV rtPA. The goal this study (SOS) obtain demographics functional outcome patients with acute ischemic from large vessel thromboembolism. Methods: SOS Trial prospective, single-arm, multicenter based United Kingdom Germany. Patients can be enrolled presenting symptoms within 8 hours...