A5020717496- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- MRI in cancer diagnosis
- Digital Mental Health Interventions
- Child and Adolescent Psychosocial and Emotional Development
- Cardiovascular Disease and Adiposity
- Mental Health Treatment and Access
- Birth, Development, and Health
- Cardiac electrophysiology and arrhythmias
- Long-Term Effects of COVID-19
- Stroke Rehabilitation and Recovery
- Music Therapy and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Thyroid Disorders and Treatments
- COVID-19 and Mental Health
- Heart Failure Treatment and Management
- Family and Disability Support Research
- Obesity, Physical Activity, Diet
- Mental Health Research Topics
- Ultrasound and Hyperthermia Applications
University of Glasgow
2016-2025
Golden Jubilee National Hospital
2015-2017
University of Sussex
2009
The aim of this study was to assess whether deferred stenting might reduce no-reflow and salvage myocardium in primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). No-reflow is associated with adverse outcomes STEMI. This a prospective, single-center, randomized, controlled, proof-of-concept trial reperfused STEMI patients ≥1 risk factors no-reflow. Randomization an intention-to-stent 4 16 h later or conventional treatment immediate...
The success of coronary reperfusion therapy in ST-segment-elevation myocardial infarction (MI) is commonly limited by failure to restore microvascular perfusion.We performed a prospective cohort study patients with reperfused MI who underwent cardiac magnetic resonance 2 days (n=286) and 6 months (n=228) post MI. A serial imaging time-course was also (n=30 participants; 4 scans): 12 hours, days, 10 7 reperfusion. Myocardial hemorrhage taken represent hypointense infarct core T2* value <20...
Background: Primary percutaneous coronary intervention is frequently successful at restoring artery blood flow in patients with acute ST-segment–elevation myocardial infarction; however, failed reperfusion commonly passes undetected up to half of these patients. The index microvascular resistance (IMR) a novel invasive measure function. We aimed investigate the pathological and prognostic significance an IMR>40, alone or combination reserve (CFR≤2.0), culprit after emergency for...
The aim of this study was to investigate the clinical significance native T1 values in remote myocardium survivors acute ST-segment elevation myocardial infarction (STEMI).The pathophysiology and prognostic natural history STEMI is uncertain. Cardiac magnetic resonance (CMR) reveals function pathology. Native (relaxation time ms) a fundamental tissue property determined by water content cellularity.A total 300 patients (mean age 59 years; 74% male) gave informed consent. A 288 had evaluable...
To assess the prognostic significance of infarct core tissue characteristics using cardiac magnetic resonance (CMR) imaging in survivors acute ST-elevation myocardial infarction (STEMI).
Background The time course and relationships of myocardial hemorrhage edema in patients after acute ST ‐segment elevation infarction ( STEMI ) are uncertain. Methods Results Patients with treated by primary percutaneous coronary intervention underwent cardiac magnetic resonance imaging on 4 occasions: at to 12 hours, 3 days, 10 7 months reperfusion. Myocardial (native T2) (T2*) were measured regions interest remote injured myocardium. was taken represent a hypointense infarct core T2* value...
Background Children’s health services in many countries are moving from single condition diagnostic silo assessments to considering neurodevelopment a more holistic sense. There has been increasing recognition of the importance clinical overlap and co-occurrence different neurotypes when assessing neurodivergent children. Using cross-sectional service evaluation design, we investigated neurodivergences cohort children referred for autism assessment, focusing on motor, learning,...
Psychological distress is common following acquired brain injury (ABI), but the evidence base for psychotherapeutic interventions small and equivocal. Positive psychotherapy aims to foster well-being by increasing experiences of pleasure, engagement meaning. In this pilot trial, we investigated feasibility acceptability brief positive in adults with ABI emotional distress. Participants were randomised plus usual treatment, or treatment only. Brief was delivered over eight individual...
The aim of this study was to mechanistically investigate associations among cigarette smoking, microvascular pathology, and longer term health outcomes in patients with acute ST-segment elevation myocardial infarction (MI). pathophysiology reperfusion injury prognosis smokers MI is incompletely understood. Patients were prospectively enrolled during emergency percutaneous coronary intervention. Microvascular function the culprit artery measured invasively. Contrast-enhanced magnetic...
This study sought to determine the incidence and prognostic significance of persistent iron in patients post–ST-segment elevation myocardial infarction (STEMI). The clinical within infarct core after STEMI complicated by acute hemorrhage is poorly understood. Patients who sustained an were enrolled a cohort (BHF MR-MI [Detection Significance Heart Injury ST Elevation Myocardial Infarction]). Cardiac magnetic resonance imaging including T2* (observed time constant for decay transverse...
The natural history and pathophysiological significance of tissue remodeling in the myocardial remote zone after acute ST-elevation infarction (STEMI) is incompletely understood. Extracellular volume (ECV) regions interest can now be measured with cardiac magnetic resonance imaging. Patients who sustained an STEMI were enrolled a cohort study (BHF MR-MI [British Heart Foundation Magnetic Resonance Imaging Acute ST-Segment Elevation Myocardial Infarction study]). Cardiac was performed at 1.5...
BACKGROUND. Failed myocardial reperfusion is common and prognostically important after acute ST-elevation infarction (STEMI). The purpose of this study was to investigate coronary flow reserve (CFR), a measure vasodilator capacity, the index microvascular resistance (IMR; mmHg × s) in culprit artery STEMI survivors.
The rationale for our study was to investigate the pathophysiology of microvascular injury in patients with acute ST-segment-elevation myocardial infarction relation a history hypertension. We undertook cohort using invasive and noninvasive measures injury, cardiac magnetic resonance imaging at 2 days 6 months, assessed health outcomes longer term. Three hundred twenty-four (mean age, 59 [12] years; blood pressure, 135 [25] / 79 [14] mm Hg; 237 [73%] male, 105 [32%] antecedent hypertension)...
<ns3:p>Background The persistence of symptoms for ≥12 weeks after a COVID-19 infection is known as Long COVID (LC), condition with unclear pathophysiology and no proven treatments to date. Living obesity risk factor LC has which may overlap aggravate LC. Methods ReDIRECT remotely delivered trial assessing whether weight management can reduce symptoms. We recruited people BMI >27kg/m2. intervention was by dietitians, online data collection (medical dietary history, vaccination, body...
Purpose To investigate the prognostic value of circumferential left ventricular (LV) strain measured by using cardiac MRI for prediction major adverse events (MACE) following an acute ST-segment–elevation myocardial infarction (STEMI). Materials and Methods Participants with STEMI were prospectively enrolled from May 11, 2011, to November 22, 2012. Cardiac was performed at 1.5 T during index hospitalization. Displacement encoding stimulated echoes (DENSE) feature tracking cine used assess LV...
New technologies, such as multi-touch tables, increasingly provide shareable interfaces where multiple people can simultaneously interact, enabling co-located groups to collaborate more flexibly than using single personal computers. Soon, these technologies will make their way into the classroom. However, little is known about what kinds of learning activities they effectively support that other mobile devices, whiteboards, and computers, are currently unable do. We suggest one most...
Obesity has some genetic basis but requires interaction with environmental factors for phenotypic expression. We examined contributions of gender-specific parental adiposity and smoking to related cardiovascular risk in adult offspring.Cross-sectional general population survey.Scotland.1456 the 1477 first generation families Midspan Family Study: 2912 parents (aged 45-64 years surveyed between 1972 1976) who had 1025 sons 1283 daughters, aged 30-59 1996.Offspring body mass index (BMI), waist...
<h3>Abstract</h3> <h3>Objective</h3> To determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment. <h3>Design</h3> Prospective cohort study. <h3>Setting</h3> Avon Longitudinal Study Parents Children in the UK. <h3>Participants</h3> 4615 mother-child pairs with an available sample (median 10 weeks gestation, interquartile range 8-12). <h3>Exposures</h3> Free thyroxine, stimulating hormone, peroxidase...
Reactive attachment disorder (RAD) is one of the least researched and most poorly understood psychiatric disorders. Very little known about prevalence stability RAD symptoms over time. Until recently it has been difficult to investigate due limited tools for informing a diagnosis. Utilising newly developed observational tool along with Disturbances Attachment Interview. this short-term prospective longitudinal study explored in maltreated young children Scotland (n=100, age range =12–62...
Cognitive deficits and low mood are common post-stroke. Music listening is suggested to have beneficial effects on cognition, while mindfulness may improve mood. Combining these approaches enhance cognitive recovery early post-stroke.To assess the feasibility acceptability of a novel mindful music intervention.A parallel group randomized controlled trial with ischemic stroke patients, comparing three groups; listening, audiobook (control group), eight weeks intervention. Feasibility was...
Abstract We developed a novel method for tracking myocardial deformation using cardiac magnetic resonance (CMR) cine imaging. hypothesised that circumferential strain deformation-tracking has comparable diagnostic performance to validated (Displacement Encoding with Stimulated Echoes- DENSE) and potentially diagnostically superior an established cine-strain (feature-tracking). 81 healthy adults (44.6 ± 17.7 years old, 47% male), without any history of cardiovascular disease, underwent CMR at...