A5015890840- Genetics and Physical Performance
- Muscle metabolism and nutrition
- Sports Performance and Training
- Cardiovascular Effects of Exercise
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Cardiovascular and exercise physiology
- Genetics and Neurodevelopmental Disorders
- Nutrition and Health in Aging
- Bone health and osteoporosis research
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Histone Deacetylase Inhibitors Research
- Nutrition, Genetics, and Disease
- Knee injuries and reconstruction techniques
- Behavioral Health and Interventions
- Physical Activity and Health
- Motivation and Self-Concept in Sports
- Mitochondrial Function and Pathology
- Genetic Associations and Epidemiology
- Single-cell and spatial transcriptomics
- Hormonal and reproductive studies
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
Victoria University
2015-2024
Australian Regenerative Medicine Institute
2022-2024
Monash University
2022-2024
Victoria School of Management
2021-2023
Murdoch Children's Research Institute
2013-2021
National Nuclear Security Administration
2021
National Academies of Sciences, Engineering, and Medicine
2021
Royal Children's Hospital
2014-2020
Ariel University
2011
Wingate Institute
2008-2011
To date, studies investigating the association between ACTN3 R577X and ACE I/D gene variants elite sprint/power performance have been limited by small cohorts from mixed sport disciplines, without quantitative measures of performance. Aim: examine these sprint time in athletes. We collected a total 555 best personal 100-, 200-, 400-m times 346 sprinters large cohort Caucasian or African origin 10 different countries. Sprinters were genotyped for ID variants. On average, male with 577RR DD...
Abstract Hand grip strength is a widely used proxy of muscular fitness, marker frailty, and predictor range morbidities all-cause mortality. To investigate the genetic determinants variation in strength, we perform large-scale discovery analysis combined sample 195,180 individuals identify 16 loci associated with ( P <5 × 10 −8 ) analyses. A number these contain genes implicated structure function skeletal muscle fibres ACTG1 ), neuronal maintenance signal transduction PEX14, TGFA, SYT1...
A common genetic variation in the alpha-actinin-3 ( ACTN3) gene causes a replacement of an arginine (R) with premature stop codon (X) at amino-acid 577 (rs1815739). While R allele has been found to be associated power-oriented performance, XX genotype may linked endurance ability. To test this hypothesis, we studied distribution ACTN3 genotypes 155 Israeli athletes (age=35.9+12.2 years) classified by sport (endurance runners and sprinters) 240 sedentary individuals. The sprinters'...
There are strong genetic components to cardiorespiratory fitness and its response exercise training. It would be useful understand the differences in genomic profile of highly trained endurance athletes world class caliber sedentary controls. An international consortium (GAMES) was established order compare elite ethnicity-matched controls a case-control study design. Genome-wide association studies were undertaken on two cohorts (GENATHLETE Japanese runners), from which panel 45 promising...
The general consensus among sport and exercise genetics researchers is that genetic tests have no role to play in talent identification or the individualised prescription of training maximise performance. Despite lack evidence, recent years witnessed rise an emerging market direct-to-consumer marketing (DTC) claim be able identify children's athletic talents. Targeted consumers include mainly coaches parents. There concern scientific community current level knowledge being misrepresented for...
Abstract Skeletal muscle tissue demonstrates global hypermethylation with age. However, methylome changes across the time-course of differentiation in aged human derived cells, and larger coverage arrays have not been undertaken. Using 850K DNA methylation we compared methylomes young (27 ± 4.4 years) (83 4 skeletal that young/aged heterogenous muscle-derived primary cells (HDMCs) over several time points (0, 72 h, 7, 10 days). Aged was hypermethylated tissue, enriched for;...
There is heterogeneity in the observed O2peak response to similar exercise training, and different approaches produce variable degrees of (trainability). The aim this study was combine data from laboratories compare trainability between various volumes interval training Moderate Intensity Continuous Training (MICT). For were classified by duration total time. High-volume High Interval (HIIT) included studies that had participants complete more than 15 min high intensity efforts per session....
Abstract Background Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on patterns across tissues. However, the construction of original pan‐tissue clock did not include skeletal muscle samples hence exhibited a strong deviation between this tissue. Methods To address this, we developed more accurate, muscle‐specific genome‐wide data 682 from 12 independent datasets (18–89 years old, 22% women, 99% Caucasian),...
An Alu insertion (I)/deletion (D) polymorphism in the angiotensin I converting enzyme (ACE) gene has been associated with ACE activity. Opposing effects on elite athletic performance have proposed for and D alleles; while allele favours improved endurance ability, promotes more power-orientated events. We tested this hypothesis by determining frequency of ID alleles amongst 121 Israeli top-level athletes classified their sporting discipline (marathon runners or sprinters). Genotyping was...
The ACTN3 R577X polymorphism (rs1815739) is a strong candidate to influence elite athletic performance. Yet, controversy exists in the literature owing between-studies differences ethnic background and sample size of cohorts, latter being usually low, which makes comparisons difficult. In this case:control genetic study we determined association between status within three cohorts European Caucasian men, i.e. Spanish, Polish Russian [633 cases (278 endurance 355 power athletes), 808...