A5037928946- Political Systems and Governance
- Genetic Associations and Epidemiology
- RNA and protein synthesis mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Genomics and Chromatin Dynamics
- Nicotinic Acetylcholine Receptors Study
- RNA modifications and cancer
- Genomic variations and chromosomal abnormalities
- RNA regulation and disease
- Fungal and yeast genetics research
- Neuroscience and Neuropharmacology Research
- Bioinformatics and Genomic Networks
- Memory and Neural Mechanisms
- Genomics and Rare Diseases
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Enzyme Structure and Function
- Gene expression and cancer classification
- Smoking Behavior and Cessation
- Genetics and Physical Performance
- CRISPR and Genetic Engineering
- Nutrition, Genetics, and Disease
- Microtubule and mitosis dynamics
- Viral-associated cancers and disorders
- RNA Research and Splicing
Open Targets
2019-2021
Wellcome Sanger Institute
2019-2020
Western University
2018-2020
MRC Epidemiology Unit
2017-2019
University of Cambridge
2017-2019
Saint Louis University
2007-2018
Lancaster University
2006-2008
Massachusetts Institute of Technology
1993
University of Iowa
1986-1989
Open Targets Genetics (https://genetics.opentargets.org) is an open-access integrative resource that aggregates human GWAS and functional genomics data including gene expression, protein abundance, chromatin interaction conformation from a wide range of cell types tissues to make robust connections between GWAS-associated loci, variants likely causal genes. This enables systematic identification prioritisation genes across all published trait-associated loci. In this paper, we describe the...
Abstract Hand grip strength is a widely used proxy of muscular fitness, marker frailty, and predictor range morbidities all-cause mortality. To investigate the genetic determinants variation in strength, we perform large-scale discovery analysis combined sample 195,180 individuals identify 16 loci associated with ( P <5 × 10 −8 ) analyses. A number these contain genes implicated structure function skeletal muscle fibres ACTG1 ), neuronal maintenance signal transduction PEX14, TGFA, SYT1...
Considerable evidence demonstrates strong comorbidity between nicotine dependence and mood anxiety disorders. Nevertheless, the neurobiological mechanisms linking adolescent exposure to disorders are not known. Disturbances in mesocorticolimbic dopamine (DA) system, comprising prefrontal cortex (PFC), ventral tegmental area (VTA), nucleus accumbens (NAc), correlates of anxiety-related symptoms this circuitry is strongly influenced by acute or chronic exposure. Using a combination behavioral...
Abstract Previous studies indicate that the distribution of corticoamygdaloid neurons in rat prelimbic (PL) and infralimbic (IL) cortices overlaps with projecting to contralateral medial prefrontal cortex (MPC), insular cortex, mediodorsal thalamus, dorsal medulla. In view poorly differentiated cytoarchitecture PL IL, their designation as cortical regions transitional between allocortex isocortex, present study sought determine whether several subcortical projections from these areas arise...
An enzyme family known as adenosine deaminases that act on RNA (ADARs) catalyzes deamination in RNA. ADARs is largely double-stranded and convert to inosine, resulting, many cases, an I·U pair. Thermodynamic parameters derived from optical melting studies are reported for a series of 14 oligoribonucleotides containing single pairs adjacent Watson−Crick pairs. In order determine unique linearly independent nearest neighbor pairs, four duplexes 3'-terminal 5'-terminal have also been...
Inosine is found naturally in the anticodon loop of tRNA, a product adenosine deaminases that act on RNA, and can be used oligonucleotide probes or to investigate role exocyclic amino group guanosine. Although thermodynamics I·U pairs RNA have been systematically studied [Wright, D. J., Rice, J. L., Yanker, M., Znosko, B. M. (2007) Biochemistry 46, 4625–4634], I·C not. Here, we performed optical melting experiments series duplexes containing compared their same A·C G–C pairs. Nearest...
Abstract Genome-wide association studies (GWAS) have identified many variants robustly associated with complex traits but identifying the gene(s) mediating such associations is a major challenge. Here we present an open resource that provides systematic fine-mapping and protein-coding gene prioritization across 133,441 published human GWAS loci. We integrate diverse data sources, including genetics (from Catalog UK Biobank) as well transcriptomic, proteomic epigenomic tissues cell types....
Abstract Long‐term tobacco dependence typically develops during adolescence and neurodevelopmental nicotine exposure is associated with affective disturbances that manifest as a variety of neuropsychiatric comorbidities in clinical preclinical studies, including mood anxiety‐related disorders. The nucleus accumbens shell (NASh) critically involved regulating emotional processing, both molecular neuronal this structure are pathologies. In the present study, we used rodent model adolescent to...
Glutamine tRNA synthetase from Saccharomyces cerevisiae has been purified to homogeneity and shown be a monomer of 91 kDa. The size the polypeptide agrees with that predicted previously reported translated DNA sequence. Mild tryptic digestion removes an amino-terminal domain releases fragment 65 kDa which begins at Ser205. This is similar in sequence Escherichia coli glutamine shows modest increase full-length yeast enzyme Km values for ATP no difference kcat aminoacylation or tRNA. Thus,...
This research has been conducted using the UK Biobank Resource under application 9905 and 19808. work was supported by Medical Research Council [Unit Programme number MC_UU_12015/2]. Full study-specific individual acknowledgements can be found in supplementary information.
Abstract Iqg1p is a component of the actomyosin contractile ring that required for actin recruitment and septum deposition. Cells lacking function have an altered bud-neck structure fail to form functional resulting in block cytokinesis septation. Here it demonstrated increased expression cytoskeleton associated protein Bsp1p bypasses requirement function. This also correlates with reduced width remedial formation. Increased this temperature-sensitive iqg1-1 background causes formation at...
Abstract Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form clonal mosaicism, yet our knowledge causes and consequences this limited. Using a newly developed approach, we estimate that 20% UK Biobank male population (N=205,011) has detectable LOY. We identify 156 autosomal genetic determinants LOY, which replicate 757,114 men European Japanese ancestry. These loci highlight genes involved cell-cycle regulation, cancer susceptibility, somatic drivers...
Introduction/Objectives Smoking tobacco is the leading cause of preventable death world‐wide and main psychoactive component tobacco, nicotine, associated with short‐ long‐term mood‐state alterations. Adolescent nicotine exposure has been shown to induce depressive anxiety‐related symptoms in adulthood. Nicotine increases ventral tegmental area (VTA) dopaminergic (DA) inputs nucleus accumbens shell (NAcSh), comprising mesolimbic DA system. Disturbances system are well‐established...