A5024329187- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Photoreceptor and optogenetics research
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Retinal Development and Disorders
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Memory and Neural Mechanisms
- GABA and Rice Research
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Pharmacological Receptor Mechanisms and Effects
- Nuclear Physics and Applications
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Retinopathy of Prematurity Studies
- Neuropeptides and Animal Physiology
- Neurological disorders and treatments
- Prenatal Substance Exposure Effects
- Advanced Neuroimaging Techniques and Applications
- Olfactory and Sensory Function Studies
Western University
2016-2024
Lawson Health Research Institute
2023
Jagiellonian University
2005-2021
University of Münster
2015-2016
University of Oslo
2012
Abstract Chronic adolescent marijuana use has been linked to the later development of psychiatric diseases such as schizophrenia. GABAergic hypofunction in prefrontal cortex (PFC) is a cardinal pathological feature schizophrenia and may be mechanism by which PFC loses its ability regulate sub-cortical dopamine (DA) resulting schizophrenia-like neuropsychopathology. In present study, we exposed rats Δ-9-tetra-hydrocannabinol (THC), psychoactive component marijuana. At adulthood, characterized...
Considerable evidence demonstrates strong comorbidity between nicotine dependence and mood anxiety disorders. Nevertheless, the neurobiological mechanisms linking adolescent exposure to disorders are not known. Disturbances in mesocorticolimbic dopamine (DA) system, comprising prefrontal cortex (PFC), ventral tegmental area (VTA), nucleus accumbens (NAc), correlates of anxiety-related symptoms this circuitry is strongly influenced by acute or chronic exposure. Using a combination behavioral...
Background and Purpose The existence of functional K v 7 channels in thalamocortical ( TC ) relay neurons the effects + ‐current termed M‐current I M on thalamic signal processing have long been debated. Immunocytochemical evidence suggests their presence this brain region. Therefore, we aimed to verify existence, pharmacological properties function regulating activity ventrobasal thalamus VB ). Experimental Approach Characterization was performed by combining vitro , vivo silico techniques...
Disturbances in prefrontal cortical (PFC) dopamine (DA) transmission are well established features of psychiatric disorders involving pathological memory processing, such as post-traumatic stress disorder and opioid addiction. Transmission through PFC DA D4 receptors (D4Rs) has been shown to potentiate the emotional salience normally nonsalient memories, whereas D1 (D1Rs) demonstrated selectively block recall reward- or aversion-related associative memories. In present study, using a...
The primary psychoactive compound in cannabis, Δ9-tetrahydrocannabinol (THC), is capable of producing bivalent rewarding and aversive affective states through interactions with the mesolimbic system. However, precise mechanisms underlying dissociable effects THC are not currently understood. In present study, we identify anatomically within rat nucleus accumbens (NAc), using an integrative combination behavioral pharmacology vivo neuronal electrophysiology. We report that vs. stimulus...
Background The olivary pretectal nucleus (OPN) is a small midbrain structure responsible for pupil constriction in response to eye illumination. Previous electrophysiological studies have shown that OPN neurons code light intensity levels and therefore are called luminance detectors. Recently, we described an additional population of neurons, characterized by slow rhythmic pattern action potentials light-on conditions. Rhythmic patterns generated these cells last period approximately 2...
We studied the ability of typical unmyelinated cortical axons to conduct action potentials at fever-like temperatures because fever often gives CNS symptoms. investigated such in cerebellar and hippocampal slices from 10 25 days old rats between 30 43°C. By recording with two electrodes along axonal pathways, we confirmed that were able initiate potentials, but >39°C, propagation a more distal site was reduced. This temperature-sensitive conduction may be specific for very thin similar...
Chronic adolescent exposure to Δ-9-tetrahydrocannabinol (THC) is linked elevated neuropsychiatric risk and induces neuronal, molecular behavioral abnormalities resembling endophenotypes. Previous evidence has revealed that the mesocorticolimbic circuitry, including prefrontal cortex (PFC) mesolimbic dopamine (DA) pathway are particularly susceptible THC-induced pathologic alterations, dysregulation of DAergic activity states, loss PFC GABAergic inhibitory control affective cognitive...
Oscillations with a period between 1 and 4 min have been previously observed in many visual system structures. To determine whether similar oscillations neuronal firing also exist rat pretectum, recordings of activity were made standard extracellular recording methods vivo. mean approximately 140 s identified 127 sites olivary pretectal nucleus (OPT). Prolonged iontophoretical current ejection bicuculline, an antagonist GABA(A) receptors, increased the rate but did not disrupt oscillatory...
Abstract The endocannabinoid (eCB) system represents a promising neurobiological target for novel anxiolytic pharmacotherapies. Previous clinical and preclinical evidence has revealed that genetic and/or pharmacological manipulations altering eCB signaling modulate fear anxiety behaviors. Water-insoluble lipid anandamide requires chaperone proteins its intracellular transport to degradation, process fatty acid-binding (FABPs). Here, we investigated the effects of FABP-5 inhibitor, SBFI-103,...
: Cannabis has shown therapeutic potential in mood and anxiety-related pathologies. However, the two primary constituents of cannabis, cannabidiol (CBD) Δ-9-tetrahydrocannabinol (THC) produce distinct effects on molecular pathways neural circuits associated with affective disorders. Moreover, it been proposed that combination THC: CBD may have unique synergistic properties. In present study, a 1:100 ratio edible formulation were tested behavioural, neuronal assays for anxiety depressive-like...
Exposure to Δ
A subpopulation of olivary pretectal nucleus (OPN) neurons discharges action potentials in an oscillatory manner, with a period approximately two minutes. This 'infra-slow' activity depends on synaptic excitation originating the retina. Signals from rod-cone photoreceptors reach OPN via axons either classic retinal ganglion cells or intrinsically photosensitive (ipRGCs), which use melanopsin for photon capturing. Although both cell types convey light information, their physiological...
Key points Neurophysiological activity in the subcortical visual system fluctuates both infra‐slow and fast oscillatory ranges, but level of co‐occurrence potential functional interaction these rhythms is unknown. Analysing dark‐adapted spontaneous mouse system, we find that two types oscillation interact uniquely through a population neurons expressing rhythms. Genetic ablation rod/cone signalling potentiates abolishes beta/gamma oscillations while genetic melanopsin substantially...