Ovarian and adrenal hyperandrogenism characterize premenopausal women with polycystic ovary syndrome (PCOS). Androgens decline age in healthy PCOS women.The objective of the study was to investigate after menopause.This a case-control, cross-sectional study.The conducted at university hospital endocrinology unit.Twenty postmenopausal 20 age- body mass index-matched controls participated study.Serum cortisol, 17-hydroxyprogesterone (17-OHP), Δ(4)-androstenedione (Δ(4)A),...

Gestational diabetes mellitus (GDM) is a common pregnancy complication, characterized by insulin resistance and low-grade systemic inflammation with pro-inflammatory immune system response. Our objective was to study the peripheral Th1, Th2, Th17 Treg response in GDM compared normal pregnancy.Th1, subsets determined flow cytometry based on staining for specific intracellular cytokines, as well C-reactive protein (CRP) total IgE circulating levels. The health status of all offspring also...

To assess the association between endogenous sex hormones and risk factors for atherosclerosis in healthy postmenopausal women.Cross-sectional study a university menopause clinic.Serum lipid-lipoprotein profile, arterial pressure, homocysteine insulin resistance, measured by homeostasis model assessment of resistance (HOMA-IR), were assessed 598 women not on hormone therapy.Compared with lowest testosterone quartile (Q), highest had higher total cholesterol (Q1: 225.2 +/- 41.3 vs Q4: 246.2...

Objective: The metabolic dysfunction accompanying the polycystic ovary syndrome (PCOS) may increase risk of hypertension and cardiovascular disease (CVD). Although menopause per se be an additional factor CVD, association between PCOS in postmenopausal women has not been adequately investigated. We aimed to evaluate effect on markers subclinical atherosclerosis nondiabetic women. Methods: This cross-sectional study included 286 with intact ovaries. phenotype was defined if three following...

Aims Urinary incontinence in general is a major cause of quality life impairment, morbidity and hospitalization. Its onset strongly linked to the menopause. Our study aimed elucidate possible relationship between endogenous circulating estrogens development stress urinary (SUI). Methods One hundred thirty eight peri‐ postmenopausal women with SUI were matched 1:1 continent based on age BMI. Morning fasting blood samples drawn from all subjects for assessment estradiol (E2), FSH, LH,...

Objectives To determine whether menopausal symptoms are associated with changes in arterial structure and function healthy, recently postmenopausal women.Methods One hundred ten women aged 45–55 years were included the present cross-sectional study. Menopausal recorded by Greene Climacteric Scale. Anthropometric measures, blood pressure, serum lipids, glucose, insulin, sex thyroid hormones determined each individual. Arterial structure, stiffness assessed intima–media thickness (IMT),...

Menopause transition is associated with chronic conditions such as osteoporosis and cardiovascular disease. Concerns about the long-term safety of menopausal hormone therapy make alternative natural methods an appealing approach to management. The aim this study was examine effect royal jelly (RJ) on bone turnover markers in clinically healthy postmenopausal women.A total 36 women were studied a prospective follow-up study. Participants received 150 mg RJ daily for three months. Circulating...

The study was aimed to find out the prevalence of non-classical congenital adrenal hyperplasia (NC-CAH) due 21-hydroxylase deficiency (21-OHdef) among Greek women with hirsutism and polycystic ovary syndrome (PCOS) compare results ACTH stimulated 17-hydroxyprogesterone 60 min (17-OHP60) values, human leukocyte antigens (HLA) phenotypes, in any patient diagnosed as having NC-CAH. One hundred seven PCOS were included study. All presented at Reproductive Endocrinology Outpatient Clinic PCOS....

Apart from the effects of a dysfunctional thyroid gland on cardiovascular system, function within reference range may have an impact vasculature. The present study aimed to evaluate association between and markers arterial structure in euthyroid postmenopausal women.The cross-sectional recruited 106 healthy women with mean age 55.0 years thyroid-stimulating hormone (TSH) levels laboratory (0.4-4.5 μIU/ml). Anthropometric biochemical measures as well blood pressure were determined each...

Objective. Nutritional deficiencies are common after bariatric surgery. We aimed to assess the prevalence and possible predictors of secondary hyperparathyroidism (SHPT) in patients. Methods. A total 95 patients who had undergone Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) were assessed a median 3 years Anthropometric/demographic weight-loss parameters compared according presence SHPT, independently for men/premenopausal women postmenopausal women. Results. SHPT was highly...

Objective We aimed to evaluate the association between thyroid hormones and indices of obesity in a sample euthyroid postmenopausal women. Design Cross-sectional study. Methods Serum levels TSH, free triiodothyronine (FT 3 ), thyroxine 4 ) as well BMI waist:hip ratio (WHR) were evaluated 194 healthy Ultrasonography was used assess abdominal fat layers (subcutaneous (SF), preperitoneal (PF), SF:PF ratio). Indices adiposity defined high vs low depending on median value assessed parameters....

The impact of physical exercise, as preventative measure, to control the progression cardiovascular disease in midlife remains under investigation. We aimed investigate effect different levels intensity activity on metabolic and vascular profile healthy postmenopausal women. A total 625 women (mean age 57.7 ± 7.6 years) were evaluated using short IPAQ questionnaire for quantification activity. energy expenditure was estimated equivalent (MET) hours per week. Pulse wave velocity (PWV)...

Objective: The aim of this study was to investigate maternal asymmetric dimethylarginine (ADMA) concentrations at the three trimesters pregnancy in uncomplicated pregnancies and women who developed preeclampsia or had small for gestational age infants (SGA) without preeclampsia. Methods: ADMA were retrospectively determined first, second third trimester 41 pregnancies, 10 complicated with 14 that delivered a SGA baby. measured an ELISA kit. Results: Mean (±SD) (µmol/L) l were: 0.51 ± 0.14;...

Postpartum mood disturbances are common among Greek women, with postpartum depression (PPD) being as high 19%. This study aimed to investigate whether sex steroid hormone levels affect the incidence of disturbances.Fifty-seven women were evaluated for using Blues Questionnaire and Edinburgh Postnatal Depression Scale on 1st 6th week. Serum estradiol, progesterone testosterone concentrations measured upon admission delivery daily until fourth day. We then studied association between scores in...

Background The aim of this study was to determine maternal serum concentrations neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9), and MMP-9/NGAL complex longitudinally in pregnancy, normal pregnancies, pregnancies that developed preeclampsia delivered a small for gestational age infant (SGA). Methods Neutrophil lipocalin, MMP-9, were determined the first, second, third trimesters 33 12 complicated by preeclampsia, 14 SGA neonate. Results Median NGAL...

Serum levels of IL-1beta, IL-6 and TNF-alpha were measured in 48 healthy, termed neonates on the 1st (N1), 5th (N5) 40th (N40) day after birth, compared with those maternal serum (MS), umbilical cord (UC) adult controls. Cytokine values N1 N5 significantly elevated, than UC controls (P<0.0001). IL-1beta declined from to N40 (P<0.0001), while increased thereafter. MS infinity IL-6, but not TNF-alpha, higher depended mode delivery. In conclusion, concentrations during perinatal period might...