A5005091367- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Reproductive Health and Technologies
- Reproductive Biology and Fertility
- Prenatal Screening and Diagnostics
- Neuroendocrine regulation and behavior
- Nitric Oxide and Endothelin Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ectopic Pregnancy Diagnosis and Management
- Pesticide and Herbicide Environmental Studies
- Pregnancy and Medication Impact
- Thyroid and Parathyroid Surgery
- Reproductive Health and Contraception
- Weed Control and Herbicide Applications
- Effects and risks of endocrine disrupting chemicals
- Intestinal and Peritoneal Adhesions
- Gynecological conditions and treatments
- Hypothalamic control of reproductive hormones
- Maternal and fetal healthcare
- Fusion and Plasma Physics Studies
- Acute Kidney Injury Research
- Medical and Biological Ozone Research
- Uterine Myomas and Treatments
- Pesticide Exposure and Toxicity
- Renin-Angiotensin System Studies
Wayne State University
2017-2022
New York University
2020
Long Island University
2020
Reproductive Medicine Associates of New York
2020
Brooklyn Hospital Center
2013-2017
Icahn School of Medicine at Mount Sinai
2016-2017
University of Pennsylvania
2016
Aretaeio Hospital
2010
National and Kapodistrian University of Athens
2010
Abstract Hypochlorous acid ( HOC l) is a potent cytotoxic oxidant generated by the enzyme myeloperoxidase MPO ) in presence of hydrogen peroxide (H 2 O and chloride (Cl − ). Elevated levels l play an important role various pathological conditions through oxidative modification several biomolecules. Recently, we have highlighted ability to mediate destruction metal‐ion derivatives tetrapyrrole macrocyclic rings such as hemoproteins vitamin B 12 VB derivatives. Destruction cyanocobalamin,...
Postpartum mood disturbances are common among Greek women, with postpartum depression (PPD) being as high 19%. This study aimed to investigate whether sex steroid hormone levels affect the incidence of disturbances.Fifty-seven women were evaluated for using Blues Questionnaire and Edinburgh Postnatal Depression Scale on 1st 6th week. Serum estradiol, progesterone testosterone concentrations measured upon admission delivery daily until fourth day. We then studied association between scores in...
Recent studies have revealed that acrolein, a commonly found toxin and potent metabolite of cyclophosphamide (CTX), can cause deterioration mouse oocyte quality through mechanism involving the generation reactive oxygen species (ROS). We extend these to evaluate effects in varying concentrations, on mitochondrial membrane apoptosis its effect embryo development vitro. Metaphase II oocytes were exposed for 45 minutes acrolein CTX (10 & 25 µM) dysfunction, major source ROS overproduction, was...
Caspase-3 is involved in apoptosis. Here, we examine whether hypochlorous acid (HOCl), a final product of myeloperoxidase (MPO), modulator caspase-3 at relatively low concentrations and also its application on metaphase II mouse oocytes. We utilised activity assay, TUNEL the CellEvent caspase 3/7 fluorescent MPO/hydrogen peroxide (H2O2) system oocytes with without cumulus cells to HOCl mediate apoptosis by inhibition caspase-3. A UV-visible spectrophotometer was used study activity. To...
Bisphenol-A (BPA) is a ubiquitous xenoestrogen found in plastic products used for food containers, paper products, water pipes, etc. Individuals exposed to BPA are susceptible detrimental effects; with poor oocyte quality, sperm motility, and impaired embryo implantation observed mouse models at levels as low 100 µg/kg/day. To investigate the mechanism through which affects development, oocytes were retrieved from 8-10-week-old mice fertilized using IVF. The embryos divided into 4 groups...