A5080588389- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Congenital Heart Disease Studies
- Ion channel regulation and function
- Congenital heart defects research
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Electrolyte and hormonal disorders
- Endoplasmic Reticulum Stress and Disease
- Pectus Deformity Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Neuroscience of respiration and sleep
- Cellular transport and secretion
- Restraint-Related Deaths
- Vascular Malformations and Hemangiomas
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Diversity and Career in Medicine
- Breastfeeding Practices and Influences
- Medical Education and Admissions
- Maternal Mental Health During Pregnancy and Postpartum
Bristol Royal Hospital for Children
2022-2024
Royal Children's Hospital
2023
New York University
2021
Royal Hospital for Children
2015-2021
Columbia University
2021
The Royal Melbourne Hospital
2020
Queen Elizabeth University Hospital
2019
University of Cambridge
2013
Cambridge University Hospitals NHS Foundation Trust
2011-2012
National and Kapodistrian University of Athens
2009
Abstract Aims Calmodulinopathy due to mutations in any of the three CALM genes (CALM1–3) causes life-threatening arrhythmia syndromes, especially young individuals. The International Registry (ICalmR) aims define and link increasing complexity clinical presentation underlying molecular mechanisms. Methods results ICalmR is an international, collaborative, observational study, assembling analysing genetic data on CALM-positive patients. has enrolled 140 subjects (median age 10.8 years...
Abstract Aims Sudden cardiac death (SCD) is the most common mode of in paediatric hypertrophic cardiomyopathy (HCM). This study describes implant and programming strategies with clinical outcomes following implantable cardioverter-defibrillator (ICD) insertion a well-characterized national HCM cohort. Methods results Data from 90 patients undergoing ICD at median age 13 (±3.5) for primary (n = 67, 74%) or secondary prevention 23, 26%) were collected retrospective, longitudinal multi-centre...
PurposeBiallelic hypomorphic variants in PPA2, encoding the mitochondrial inorganic pyrophosphatase 2 protein, have been recently identified individuals presenting with sudden cardiac death, occasionally triggered by alcohol intake or a viral infection. Here we report 20 new families harboring PPA2 variants.MethodsSynthesis of clinical and molecular data concerning 34 five previously reported 12 novel variants, 11 which were functionally characterized.ResultsAmong individuals, only 6 remain...
Pacing in a univentricular circulation has been associated with worsened outcomes. We investigated the long-term outcomes of pacing children compared to complex biventricular circulation. also identified predictors adverse
<title>Abstract</title> Importance: Pediatric cardiac symptoms such as palpitations, syncope, or seizure-like episodes pose diagnostic challenges for general pediatricians. These symptoms, though often benign, may reveal underlying arrhythmias inherited conditions (ICCs), affecting the quality of life and limiting activity participation. Purpose: To determine effectiveness safety implantable loop recorders (ILRs) in diagnosing managing pediatric patients. Methods: A retrospective cohort...
Abstract Proteus syndrome is an extremely rare overgrowth condition caused by a somatic variant of the AKT1 gene. It can involve multiple organ systems though rarely there symptomatic cardiac involvement. Fatty infiltration myocardium has been described but not reported to cause functional or conduction abnormalities. We present individual with who suffered sudden arrest.
Homozygous plakophilin-2 (
Pediatric cardiac symptoms such as palpitations, syncope, or seizure-like episodes pose diagnostic challenges for general pediatricians. These symptoms, though often benign, may reveal underlying arrhythmias inherited conditions (ICCs), affecting the quality of life and limiting activity participation. The purpose this study is to determine effectiveness safety implantable loop recorders (ILRs) in diagnosing managing pediatric patients. A retrospective cohort conducted over an 8-year period...
Abstract There is growing interest in the use of digital medicine to reduce need for traditional outpatient follow-up. Remote interrogation pacemakers and implantable cardioverter defibrillators now possible with most devices. The aim our study was evaluate safety efficacy virtual pacing clinics following up children defibrillators, including epicardial systems. Methods: retrospective over 8 years (2010–2017), review patient records analysis downloads from cardiac devices clinics. Results: A...
This 16-year-old male with Holt-Oram syndrome underwent a secundum atrial septal defect and partial anomalous pulmonary venous drainage repair followed by implantation of an epicardial dual-chamber permanent pacemaker at 6 years for sinus node dysfunction. He had marked pectus excavatum deformity that became progressively worse during adolescence. Ten after he reported episodes presyncope exclusively exercise. Serial interrogation revealed rapid non-sustained ventricular tachycardia...
Abstract The effect of growth on the subcutaneous cardioverter defibrillators when implanted in small children is unknown. These two chest X-rays demonstrate that these devices can cope well with growth.
<h3>Background</h3> NICE guidelines on antibiotic prophylaxis against infective endocarditis (IE) were published in 2008 resulting a change practice. There are recommendations for ongoing audit to monitor the incidence of IE, particularly high risk congenital heart disease (CHD) population. <h3>Methods</h3> This is retrospective review cases paediatric patients with CHD Scotland. Patients identified from cardiac unit database. The current 30-month period was compared two previous audits that...
Abstract Implantable loop recorders (ILR) have emerged as long-term effective monitoring tools for severe or recurrent rhythm abnormalities unexplained cardiac symptoms. Scarce information is available on the use and results of this technology in pediatric age. Report a cohort patients that benefited from ILR implantation. Retrospective chart review clinical data, implantation indications, diagnostic recordings changes patient management who underwent Reveal LINQ January 2016 to February...
<h3>Aims</h3> Medical shadowing helps applicants to medical school improve their CV and determine suitability for a career. Previously in our tertiary paediatric service was arranged individually by Consultants. To equity of access, adherence national guidance quality experiences we initiated new, formal programme. <h3>Methods</h3> Questionnaires are sent students before after each placement what extent aims students9 learning objectives achieved. <h3>Results</h3> Over 8 months 16 enquired...