A5062707519- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Climate Change and Health Impacts
- COVID-19 Clinical Research Studies
- Cardiac Imaging and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Acute Ischemic Stroke Management
- Heart Rate Variability and Autonomic Control
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
- Liver Disease Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Psoriasis: Treatment and Pathogenesis
- Thermoregulation and physiological responses
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological Disorders and Treatments
- GDF15 and Related Biomarkers
- Diet, Metabolism, and Disease
- Venous Thromboembolism Diagnosis and Management
National and Kapodistrian University of Athens
2016-2025
University General Hospital Attikon
2017-2025
Background We investigated the effects of insulin, glucagon‐like peptide‐1 receptor agonists ( GLP ‐1 RA ), sodium‐glucose cotransporter‐2 inhibitors SGLT ‐2i), and their combination on vascular cardiac function patients with type 2 diabetes mellitus. Methods Results A total 160 mellitus were randomized to insulin (n=40), liraglutide empagliflozin or + ‐2i) (n=40) as add‐on metformin. measured at baseline 4 12 months posttreatment: (a) perfused boundary region sublingual arterial...
We investigated the association of endothelial glycocalyx damage with arterial stiffness, impairment coronary microcirculatory function, and LV myocardial deformation in 320 untreated hypertensives 160 controls. measured perfused boundary region ( PBR ) sublingual microvessels, a marker inversely related thickness, flow reserve CFR ), Global Longitudinal strain GLS by echocardiography, pulse wave velocity PWV central systolic blood pressure cSBP ). Hypertensives had higher , lower than...
Background and Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RA) sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are cardioprotective drugs. We investigated their effects on left atrial function, a major determinant of cardiac diastolic dysfunction in type 2 diabetes mellitus. also explored the association changes arterial stiffness with those LA strain after treatment. Materials Methods: A total 200 patients (59.5 ± 9.1 year old, 151 male) mellitus treated metformin were...
Hydroxytyrosol reduces low-density lipoprotein oxidation, contributing to prevention of atherosclerosis progression.In a prospective, crossover, double-blind, placebo-controlled trial, 30 chronic coronary artery syndrome (CCAS) patients were randomized 4 capsules/day, containing 412.5 mg olive oil with 2.5 hydroxytyrosol (OOHT) each one or placebo for 1 month and then crossed over the alternate treatment (placebo OOHT). We measured (a) perfused boundary region (PBR) sublingual arterial...
Abstract Background/Introduction Coronavirus disease 2019 (COVID-19) has been associated with impaired subclinical markers of endothelial and vascularfunction. Purpose We investigated whether intervention Endocalyx (Microvascular Health Solutions),a dietary supplement containing glycosaminoglycans fucoidan, can improve glycocalyx integrity,arterial stiffness, coronary microcirculationin patients after COVID-19 infection. Methods Fiftypatients within 15 days a confirmed mild-to-moderate...
Abstract Background/Introduction Psoriatic disease is associated with impaired endothelial and vascular function. Purpose We investigated whether intervention Endocalyx (Microvascular Health Solutions),a dietary supplement containing glycosaminoglycans fucoidan, can improve glycocalyx integrity arterial stiffness in patients psoriatic disease. Methods Thirty were randomized to receive (n=15) or placebo for 4 months. measured at baseline months of treatment: a)perfused boundary region(PBR)...
Background We investigated the effects of combined treatment with glucagon like peptide‐1 receptor agonists (GLP‐1RA) and sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2i) on NT‐proBNP (N‐terminal pro‐brain natriuretic peptide), GDF‐15 (growth differentiation factor 15), MOTS‐c (mitochondrial‐derived peptide‐c) in patients type 2 diabetes (T2D) high or very cardiovascular risk. Methods studied 163 consecutive who were treated insulin (n=40), liraglutide (n=41), empagliflozin (n=42), their...
Imbalance between oxidative stress burden and antioxidant capacity is implicated in the course of atherosclerosis among type 2 diabetic patients. We addressed effects insulin, glucagon-like peptide-1 receptor agonists (GLP1-RA), sodium-glucose cotransporter-2 inhibitors (SGLT-2i), their combination on levels oxidant biomarkers. recruited a total 160 diabetics, who received insulin (n = 40), liraglutide empagliflozin or (GLP-1RA+SGLT-2i) 40). measured at baseline, 4 12 months treatment: (a)...
Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD) has been associated with increased cardiovascular risk. The aim of this Randomized Double-blind clinical Trial was to evaluate the effects coenzyme-Q10 supplementation in patients MASLD terms endothelial, vascular and myocardial function.
Clinical studies have previously established the role of olive products in cardiovascular disease (CVD) prevention, whilst identification responsible constituents for beneficial effects is still pending. We sought to assess and compare cardioprotective potential oleuropein (OL), hydroxytyrosol (HT), oleocanthal (OC) oleanolic Acid (OA), regarding Ischemia/Reperfusion Injury (IRI) CVD risk factors alleviation. The scope study was design a potent safe combinatorial therapy...
Poor glycaemic control affects myocardial function. We investigated changes in endothelial function and left ventricular (LV) deformation poorly controlled type 2 diabetics before after intensification.In 100 poorly-controlled diabetic patients (age: 51 ± 12 years), we measured at baseline months intensified control: (a) Pulse wave velocity (PWV, Complior); (b) flow-mediated dilatation (FMD, %) of the brachial artery; (c) perfused boundary region (PBR) sublingual arterial micro-vessels...
Cardioembolism is a postulated mechanism of embolic stroke undetermined source (ESUS). We investigated endothelial glycocalyx, aortic elastic properties, oxidative stress, and their association with left atrial (LA) function in ESUS healthy individuals. In 90 patients (age 50.4 ± 13.2) controls similar risk factors, we measured: (1) perfused boundary region (PBR) the sublingual arterial microvessels (range 5-25 µm), marker inversely related glycocalyx thickness, (2) pulse wave velocity...
The phosphodiesterase 4 inhibitor apremilast is used for the treatment of psoriasis. We investigated effects on endothelial glycocalyx, vascular and left ventricular (LV) myocardial function in One hundred fifty psoriatic patients were randomized to (n = 50), anti-tumor necrosis factor-α (etanercept; n or cyclosporine 50). At baseline months post-treatment, we measured: (1) Perfused boundary region (PBR), a marker glycocalyx integrity, sublingual microvessels with diameter 5-25 μm using...
In elderly patients with cardiac diseases, changes in cardiovascular physiology diminish reserve and predispose to hemodynamic instability after spinal anesthesia; hence, such could be at risk of postoperative complications. Additionally, transthoracic echocardiography (TTE) is used clinical practice evaluate hemodynamics. Therefore, we hypothesized that echocardiographic measurements display significant diagnostic power the prediction post - anesthesia hypotension diseases reduced left...
Abstract Context The cardiovascular benefits of semaglutide are established; however, its effects on surrogate vascular markers and liver function not known. Objective To investigate the vascular, endothelial, in patients with type 2 diabetes (T2DM) nonalcoholic fatty disease (NAFLD). Methods Overall, 75 consecutive subjects T2DM NAFLD were enrolled: 50 received 1 mg (treatment group) 25 dipeptidyl peptidase 4 inhibitors (control group). All underwent a clinical, hepatic examination...
Abstract We compared the effects of Heat-not-Burn cigarette (HNBC) to those tobacco (Tcig), on myocardial, coronary and arterial function as well oxidative stress platelet activation in 75 smokers. In acute study, 50 smokers were randomised into smoking a single Tcig or HNBC after 60 min crossed-over alternate smoking. For chronic phase, switched with an external group 25 before 1 month. Exhaled carbon monoxide (CO), pulse wave velocity (PWV), malondialdehyde (MDA) thromboxane B2 (TxB2)...