A5013529493- Sepsis Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Nutrition and Health in Aging
- Pneumonia and Respiratory Infections
- Vitamin C and Antioxidants Research
- Emergency and Acute Care Studies
- Epilepsy research and treatment
- Mechanical Circulatory Support Devices
- Neonatal Respiratory Health Research
- Electrolyte and hormonal disorders
- Trace Elements in Health
- Suicide and Self-Harm Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Personality Traits and Psychology
- Adrenal Hormones and Disorders
- Immune Response and Inflammation
- Workplace Violence and Bullying
- Thermal Regulation in Medicine
- Inflammation biomarkers and pathways
- Nosocomial Infections in ICU
- Antibiotics Pharmacokinetics and Efficacy
- Cell death mechanisms and regulation
National and Kapodistrian University of Athens
2009-2024
University of Crete
2017-2023
University General Hospital Attikon
2022
University Hospital of Heraklion
2017-2022
Panagiotis & Aglaia Kyriakou Children's Hospital
2021
Crete University Press
2019
Oxidative stress is considered pivotal in the pathophysiology of sepsis. Oxidants modulate heat shock proteins (Hsp), interleukins (IL), and cell death pathways, including apoptosis. This multicenter prospective observational study was designed to ascertain whether an oxidant/antioxidant imbalance independent sepsis discriminator mortality predictor intensive care unit (ICU) patients with (n = 145), compared non-infectious critically ill 112) healthy individuals 89). Serum total oxidative...
Abstract Sepsis is a dysregulated host response to infection related devastating outcomes. Recently, interest has been shifted towards apoptotic and antiapoptotic pathobiology. Apoptosis executed through the activation of caspases regulated by number proteins, such as survivin. The survivin caspases’ responses sepsis have not yet elucidated. This multicenter prospective observational study concerning patients with (n = 107) compared traumatic systemic inflammatory syndrome (SIRS) 75) healthy...
In elderly patients with cardiac diseases, changes in cardiovascular physiology diminish reserve and predispose to hemodynamic instability after spinal anesthesia; hence, such could be at risk of postoperative complications. Additionally, transthoracic echocardiography (TTE) is used clinical practice evaluate hemodynamics. Therefore, we hypothesized that echocardiographic measurements display significant diagnostic power the prediction post - anesthesia hypotension diseases reduced left...
Background: Surveillance is essential to all aspects of management healthcare-associated infections (HAIs) in critically ill children, where data are limited. We conducted an active surveillance study elucidate epidemiology, resistance, antimicrobial treatment practices and outcomes pediatric intensive care unit-acquired HAIs a southern European country. Methods: Four Greek unit encounters (153 patients, 2183 patient-days) during 6-month period participated using the Centre for Disease...
Open endotracheal suctioning (ETS), which is performed regularly in mechanically ventilated patients to remove obstructive secretions, can cause an immediate decrease dynamic compliance and expired tidal volume result inadequate or inaccurate sidestream respiratory monitoring, necessitating prolonged periods of stabilization connected metabolic monitors. We investigated the effect open ETS on accuracy oxygen consumption (VO2) carbon dioxide production (VCO2) measurements calculated lung...
Background: Nutritional support of preterm infants remains a field debate in the literature and clinical practice varies significantly. Adequate nutrition should promote growth aim for optimal later neurodevelopment. However, it is often impaired by prematurity-associated morbidity physiologic immaturity infants. This study assessed impact energy macronutrient provision on velocity outcome explored differences attributed to heterogeneity population. Methods: We retrospectively collected...
We evaluated the validity of sixteen predictive energy expenditure equations for resting estimation (eREE) against measured using indirect calorimetry (REEIC) in 153 critically ill children. Predictive were included based on weight, height, sex, and age. The agreement between eREE REEIC was analyzed Bland–Altman method. Precision defined by 95% limits agreement; differences > ±10% from considered clinically unacceptable. reliability assessed intraclass correlation coefficient (Cronbach’s...
Optimal energy provision, guided by measured resting expenditure (REE) and determined indirect calorimetry (IC), is fundamental in Intensive Care Units (ICU). Because IC availability limited, methods to predict REE based on carbon dioxide production (VCO2) measurements (REEVCO2) alone have been proposed as a surrogate for (REEIC). The study aimed at externally internally validating the accuracy of REEVCO2 an alternative REEIC mechanically ventilated children. A ventilator’s integrated gas...
It is unknown whether lung mechanics differ between patients with pediatric ARDS and at risk for ARDS. We aimed to examine the hypothesis that, compared ARDS, subjects of are characterized by higher end-expiratory volume (EELV) or respiratory system compliance (CRS) lower distending pressure (stress) applied on parenchymal deformation (strain) during mechanical ventilation.Consecutively admitted fulfilling PALICC criteria were considered eligible inclusion in this study. A ventilator an...
1Pediatric Intensive Care Unit, Postgraduate Program: "Emergency and in Children Adolescents Young Adults," School of Medicine, University Crete, Heraklion, Greece. 2Second Department Anaesthesiology, Attikon Hospital, National Kapodistrian Athens, *See also p. e578. The authors have disclosed that they do not any potential conflicts interest.
Suicidality is a growing public health problem in children and adolescents. The aim of this retrospective data analysis study was to estimate the prevalence suicidality pediatric patients admitted an academic Pediatric Psychiatric Clinic (PPC) analyze social environmental risk factors associated with suicide. Suicidal ideation assessed by Self-Injurious Thoughts Behaviors Interview. Using established psychometric scales, stressful events were analyzed. During four-year study, 249 episodes...