A5080433287- Stress Responses and Cortisol
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Estrogen and related hormone effects
- Heat shock proteins research
- Neuropeptides and Animal Physiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Diet and metabolism studies
- Biomarkers in Disease Mechanisms
- Birth, Development, and Health
- Receptor Mechanisms and Signaling
- Anesthesia and Neurotoxicity Research
- NF-κB Signaling Pathways
- Sepsis Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Neuroscience and Neuropharmacology Research
- Growth Hormone and Insulin-like Growth Factors
- Infant Nutrition and Health
- Cancer, Stress, Anesthesia, and Immune Response
- Erythropoietin and Anemia Treatment
- Hypothalamic control of reproductive hormones
- Periodontal Regeneration and Treatments
University of Crete
2016-2025
University of Veterinary Medicine Vienna
2014
Foundation for Research and Technology Hellas
2010
Harvard University
2000-2006
Boston Children's Hospital
1999-2006
Lexington VA Health Care System
1998
Hemangiomas are the most common tumors of infancy, with a prevalence 5 to 10 percent among one-year-olds. They characterized by rapid growth in first year life, followed involution and gradual regression adolescence.1,2 We recently treated three-month-old infant massive hepatic hemangiomas primary hypothyroidism who needed very high doses thyroid hormone restore euthyroidism normal thyrotropin secretion. This finding suggested that rate degradation was accelerated. subsequently identified...
Activated macrophages are described as classically activated or M1 type and alternatively M2 type, depending on their response to proinflammatory stimuli the expression of genetic markers including iNOS, arginase1, Ym1, Fizz1. Here we report that Akt kinases differentially contribute macrophage polarization, with Akt1 ablation giving rise an Akt2 resulting in phenotype. Accordingly, −/− mice were more resistant LPS-induced endotoxin shock dextran sulfate sodium (DSS)-induced colitis than...
Prenatal exposure to endocrine-disrupting chemicals such as persistent organic pollutants (POPs) may increase risk of obesity later in life.We examined the relation utero POPs offspring and cardiometabolic factors at 4 years age Rhea mother-child cohort Crete, Greece (n = 689).We determined concentrations polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB) first-trimester maternal serum. We measured child weight, height, waist circumference,...
Purpose The aim of this study was to examine the effects a six-week off-season detraining period on exercise performance, body composition, and circulating sex steroid levels in soccer players. Methods Fifty-five professional male players, members two Greek Superleague Teams (Team A, n = 23; Team B, 22), participated study. first weeks players abstained from any physical activity. following four weeks, performed low-intensity (50%–60% VO2max) aerobic running 20 30 minutes duration three...
Few studies have investigated longitudinal associations between early life phthalate exposure and subsequent obesity cardiovascular risks in children with inconsistent results. We aimed to evaluate the during gestation childhood offspring cardiometabolic risk factors 500 mother-child pairs from Rhea pregnancy cohort Crete, Greece. Seven metabolites [monoethyl (MEP), mono-n-butyl (MnBP), mono-isobutyl (MiBP), monobenzyl (MBzP), mono(2-ethylhexyl) (MEHP), mono(2-ethyl-5-hydroxyhexyl) (MEHHP),...
Adiponectin, a hormone secreted by adipose tissue, circulates at high concentrations in human plasma. Paradoxically, plasma levels of adiponectin are approximately 50% lower obese than lean subjects. An association between low and higher risk developing breast other cancers was recently reported. Obesity overweight have also been associated with increased mortality from cancer. To test the hypothesis that exerts direct antiproliferative and/or pro-apoptotic effects on cancer cells, we used...
Stimulation of the hypothalamic-pituitary-adrenal (HPA) axis by proinflammatory cytokines results in increased release glucocorticoid that restrains further development inflammatory process. IL-6 has been suggested to stimulate HPA during immune activation independent input hypothalamic corticotropin-releasing hormone (CRH). We used hormone–deficient (Crh+/+) mouse elucidate effect CRH deficiency on expression and IL-6–induced turpentine-induced inflammation. demonstrate inflammation is...
Abstract Following its discovery 20 years ago, corticotropin‐releasing hormone (CRH) has been postulated to mediate both hormonal and behavioural responses stressors. Here, we characterize describe a role for the murine gene, UcnIII , which encodes recently discovered CRH‐related neuropeptide, urocortin III. We found that mouse is expressed predominantly in regions of brain known be involved stress‐related behaviours, expression hypothalamus increases following restraint. In addition,...
Published evidence suggests that obesity impairs cognition. Development of chronic low-grade inflammation (CLGI) represents the earliest consequence obesity. The present study investigated association between and fluid intelligence impairment assessed potential mediating role CLGI psychological (depression/anxiety symptoms), lifestyle (exercise) physiological (metabolic dysfunction indices) factors in this association. Clinically healthy participants ( n 188), grouped as per BMI, underwent...
Oxidative stress is considered pivotal in the pathophysiology of sepsis. Oxidants modulate heat shock proteins (Hsp), interleukins (IL), and cell death pathways, including apoptosis. This multicenter prospective observational study was designed to ascertain whether an oxidant/antioxidant imbalance independent sepsis discriminator mortality predictor intensive care unit (ICU) patients with (n = 145), compared non-infectious critically ill 112) healthy individuals 89). Serum total oxidative...
The hypothalamic-pituitary-adrenal (HPA) axis, including hypothalamic corticotropin-releasing hormone (CRH) and pituitary corticotropin, is one of the first endocrine systems to develop during fetal life, probably because glucocorticoid secretion necessary for maturation many essential organs. Consistent with this, pregnant mice an inactivating mutation in Crh gene deliver CRH-deficient offspring that die at birth dysplastic lungs, which can be prevented by prenatal maternal treatment. But...
Mammalian heat-shock-protein (HSP) 90α rapidly responses to environmental insults. We examined the hypothesis that not only serum HSP72 but also HSP90α is increased in systemic inflammatory response syndrome (SIRS), severe-sepsis (SS), and/or sepsis (S) compared healthy children (H); we assessed relation (a) multiple organ system failure (MOSF) and (b) inflammatory-metabolic severity of illness.A total 65 with S, SS, or SIRS 25 H were included. ELISA was used evaluate extracellular HSP72,...
Introduction: Endometrial cancer is one of the most common gynecological malignancies. cells express gonadotropin-releasing hormone (GnRH) and its receptor (GnRH-R). Among various therapeutic approaches for treatment endometrial use GnRH conjugates, such as AN-152, created by linking [D-Lys6] with cytotoxic doxorubicin through an ester bond. An undesirable property these conjugates their vulnerability to plasma carboxylesterases, which cleave bond release before reaching cells. Methods: To...
During tissue injury or infection, leukocytes are activated to produce proinflammatory mediators, which trigger the immune system anti-inflammatory and analgesic molecules. Our previous studies provide evidence that synthetic microneurotrophins, like BNN27, exert significant effects during Complete Freund’s Adjuvant (CFA)-induced inflammation pain. Thus, aim of present study was examine if effect BNN27 on inflammatory pain is mediated at least in part by activation T-lymphocytes. For this...
Cancer cells secrete bioactive peptides that act in an autocrine or paracrine fashion affecting tumor growth and metastasis. Corticotropin-releasing factor (CRF), a hypothalamic neuropeptide controls the response to stress, has been detected breast cancer tissues cell lines. CRF can affect manner via its production from innervating sympathetic neurons immune cells.In present study we report our findings regarding impact of on motility invasiveness. For this purpose used MCF7 line evaluated...
Epidermal organization and homeostasis are regulated by mesenchymal influences through paracrine actions. Until today, dermal fibroblasts (DFs) used in the "dermal" layer to support keratinocyte growth vitro skin substitutes. In present work, we human adipose tissue-derived cells (ADMCs) as a of (in monolayer culture 3D cell models) vivo (mouse wound healing compared our findings with those obtained using fibroblasts. ADMCs induce reepithelialization during more efficiently than DFs,...
Traumatic brain injury (TBI) is currently one of the leading causes mortality and disability worldwide. At present, no reliable inflammatory or specific molecular neurobiomarker exists in any standard models proposed for TBI classification prognostication. Therefore, present study was designed to assess value a group mediators evaluating acute TBI, combination with clinical, laboratory radiological indices prognostic clinical scales. In single-centre, prospective observational study, 109...
Corticotropin-releasing hormone is a main regulator of mammalian stress response by stimulating pituitary proopiomelanocortin (POMC) gene expression, and thus adrenocorticotropic (ACTH) secretion, which then causes glucocorticoid release from the adrenal. In recent study in corticotroph cell line AtT20, oxidative stimulated activity nuclear transcription factor B (NF-κB), whereas corticotropin-releasing (CRH) inhibited both constitutive stress-induced NF-κB DNA-binding activity. To further...
Upon binding of the corticotropin-releasing factor (CRF) analog sauvagine to type 1 CRF receptor (CRF<sub>1</sub>), amino-terminal portion peptide has been shown lie near Lys257 in receptor9s second extracellular loop (EL2). To test hypothesis that EL2 residues play a role CRF<sub>1</sub> we carried out an alanine-scanning mutagenesis study determine functional (Leu251 Val266). Only W259A, F260A, and W259A/F260A mutations reduced affinity potency sauvagine. In contrast, these did not seem...