Panagiotis Simitsis

ORCID: 0000-0001-8215-7893
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About
Contact & Profiles
Research Areas
  • Cardiovascular Function and Risk Factors
  • Heart Failure Treatment and Management
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Cardiac electrophysiology and arrhythmias
  • Sepsis Diagnosis and Treatment
  • Takotsubo Cardiomyopathy and Associated Phenomena
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Cardiac Imaging and Diagnostics
  • Blood Pressure and Hypertension Studies
  • Atrial Fibrillation Management and Outcomes
  • Cardiovascular and exercise physiology
  • Cardiac Arrhythmias and Treatments
  • Stress Responses and Cortisol
  • Cardiac Structural Anomalies and Repair
  • Hormonal Regulation and Hypertension
  • Hemodynamic Monitoring and Therapy
  • Cardiovascular Issues in Pregnancy
  • Hemoglobinopathies and Related Disorders
  • CAR-T cell therapy research
  • Cardiac pacing and defibrillation studies
  • Cardiac Valve Diseases and Treatments
  • Cardiovascular Health and Disease Prevention
  • Infective Endocarditis Diagnosis and Management
  • Forensic Toxicology and Drug Analysis
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients

Brigham and Women's Hospital
2023-2025

National and Kapodistrian University of Athens
2011-2024

University General Hospital Attikon
2013-2024

Harvard University
2023

King's College Hospital
2018

British Heart Foundation
2018

King's College London
2018

King's College Hospital NHS Foundation Trust
2018

Takotsubo syndrome (TTS) is not usually diagnosed until patients with suspected acute coronary (ACS) and echocardiographically detected apical aneurysm are found to have "normal" angiography (CA). Our aim was explore whether cardiac biomarkers can contribute the early diagnosis of TTS.

10.1016/j.hjc.2023.05.010 article EN cc-by Hellenic Journal of Cardiology 2023-06-01

The objective of this study was to compare rates redo surgery for the Medtronic Mosaic 305 A Porcine Prosthesis and Carpentier-Edwards Perimount Pericardial Aortic Bioprosthesis 2900. This a single-centre retrospective observational study. We included all 1018 patients who underwent aortic valve replacement with (n = 216) or 809) bioprosthesis between October 2000 August 2008. total follow-up 1508 patient-years 5813 valve. maximal interquartile range were 14.8 7.0 years 15.1 5.6 valve,...

10.1093/ejcts/ezy113 article EN European Journal of Cardio-Thoracic Surgery 2018-02-24

The impact of ranolazine, an anti-ishemic agent with antiarrhythmic properties, on paroxysmal atrial fibrillation (PAF) in patients coronary artery disease (CAD) remains unclear. Pacing devices can be useful tools for disclosing even asymptomatic PAF. Purpose this study is to assess the effect ranolazine (AF), CAD, PAF and a dual-chamber pacemaker. We studied 74 PAF, sick sinus syndrome or atrio-ventricular block, treated pacemakers capable detect episodes. total time AF, AF burden, number...

10.4022/jafib.940 article EN PubMed 2014-02-28

Abstract Aim Endothelial glycocalyx is involved in the clinical course of atherogenesis. The purpose this study was to investigate whether disturbance integrity related with increased cardiovascular risk. Methods Perfused Boundary Region (PBR), a marker integrity, measured non-invasively sublingual microvessels diameter ranging from 5–25 μm using dedicated camera (Sideview, Darkfield Imaging). Increased PBR indicates reduced thickness. We baseline 400 apparently healthy subjects, without...

10.1093/eurheartj/ehab724.2503 article EN European Heart Journal 2021-10-01

Abstract Background/Introduction Chronic stress is considered to be an important element of residual cardiovascular risk and modern guidelines recommend its systematic assessment treatment. Its pathophysiologic contribution, however, in acute myocardial infarction (AMI) was not, until recently, easy elucidate. This arises from difficulties objectively quantifying levels using conventional research methods, like questionnaires. Purpose The purpose our study measure at the days preceding a...

10.1093/eurheartj/ehae666.1489 article EN European Heart Journal 2024-10-01

Background: There are limited data regarding left ventricular ejection fraction (LVEF) recovery rates among patients with anthracycline-induced cardiomyopathy (AIC). Aims: To assess the rate of LVEF and its predictors in a contemporary heterogenous cohort AIC. Methods: A retrospective study adult new onset determined to be secondary anthracyclines after comprehensive work-up for potential etiologies within Massachusetts General Brigham between 2010 2023. was defined as an absolute increase...

10.1161/circ.150.suppl_1.4142220 article EN Circulation 2024-11-12

Background Chronic stress is believed to play a role in the pathophysiology of acute myocardial infarction (AMI). Cortisol biomarker associated with stress. We sought assess contribution AMI using hair cortisol concentration (HCCs) as surrogate biomarker. Methods HCC was measured segments, corresponding distinctive periods before sampling, 102 male patients and 50 healthy controls. Standard baseline variables were collected for both groups, whereas patients, laboratory psychological tests...

10.1097/mca.0000000000001468 article EN Coronary Artery Disease 2024-12-02

Abstract Background Takotsubo syndrome (TTS) is frequently triggered by stressful events suggesting that increased sympathetic activity has a role in its pathophysiology. Hair cortisol concentration (HCC) promising biomarker of excess chronic stress measuring secreted into hairs over several weeks. Purpose We explored whether premorbid ongoing weeks assessed HCC at 2 intervals associated with the occurrence TTS. Methods A case-control prospective study was performed recruiting 18 consecutive...

10.1093/eurheartj/ehae666.1714 article EN European Heart Journal 2024-10-01
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