Ranolazine is a relatively novel antiischemic/antianginal compound with antiarrhythmic properties. We investigated its ability to shorten the time conversion of postoperative atrial fibrillation (POAF) when added amiodarone after coronary artery bypass graft (CABG) surgery. In this prospective, randomized, allocation-concealed, single-blind, single-site clinical trial, we enrolled consecutive eligible patients who developed POAF elective on-pump CABG Participants were randomized receive...

Ranolazine is a new anti-ischemic agent approved for chronic angina with additional electrophysiologic properties. The purpose of the present trial was to investigate its effect in preventing postoperative atrial fibrillation (POAF) after on-pump coronary artery bypass graft (CABG) surgery.In current prospective, randomized, (1 active: 2 control), single-blind (outcome assessors), single-centre clinical we recruited consecutive eligible patients scheduled elective CABG. Participants were...

Background Amiodarone (AMIO) is for many years effectively used to control ventricular rate during atrial fibrillation (AF) and convert it into sinus rhythm. However, due its delayed onset of action, ranolazine (RAN), a new antianginal agent with atrial‐selective electrophysiologic properties, has recently been attempted as add‐on therapy AMIO facilitate AF conversion. Methods To establish the role this combination therapy, we enrolled 173 consecutive patients (68 ± 10 years, 54% male)...

Ranolazine (Ran) is a novel anti-ischemic agent with electrophysiologic properties mainly attributed to the inhibition of late Na(+) current and atrial-selective early current. However, there are only limited data regarding its efficacy mechanism action against atrial flutter (Afl) fibrillation (AF) in intact animals. Therefore, we aimed investigate Ran rabbit model inducible tachyarrhythmias elicited by acetylcholine (ACh). Arrhythmias were produced 19 rabbits rapid burst pacing during...

Potassium channel openers are known to act on potassium ATP-dependent channels in cardiac tissue. Such agents may exacerbate acceleration of acute ischemia-induced ventricular repolarization and aggravate arrhythmias. To test whether activation K ATP during the healing period myocardial infarction (MI) can still influence electrophysiologic properties type inducible arrhythmias, we investigated effects bimakalim (BIM) sustained tachycardia (VT) 4 days after ligation left anterior descending...

The impact of ranolazine, an anti-ishemic agent with antiarrhythmic properties, on paroxysmal atrial fibrillation (PAF) in patients coronary artery disease (CAD) remains unclear. Pacing devices can be useful tools for disclosing even asymptomatic PAF. Purpose this study is to assess the effect ranolazine (AF), CAD, PAF and a dual-chamber pacemaker. We studied 74 PAF, sick sinus syndrome or atrio-ventricular block, treated pacemakers capable detect episodes. total time AF, AF burden, number...

Ranolazine (RAN) and nicardipine (NIC) have been studied for their vasorelaxing eff ects but the combination of these agents against adrenergic vasoconstriction has not tested. The present study aimed at investigating ect by two on alpha1-adrenoceptor-mediated contraction isolated rabbit aorta. Aortic rings were mounted isometric tension recording in organ baths containing Krebs-Henseleit solution. Concentration-response curves RAN (10–9 to 10–4 M), NIC 10–5 + (3 × 10–6 M) obtained a...

In 12 open-chest dogs, cardiac sympathetic nervous activity (CSNA) was recorded before and after occlusion of the left anterior descending coronary artery as well during reperfusion ventricular fibrillation (VF). 7 control animals, CSNA did not significantly differ from preocclusion levels when determined 20 min (+3.5 +/- 1.5%, mean SEM) up to 15 following (+1.5 0.6%). However, VF associated with a potential increase in by 106 15.5% (p less than 0.001). The effect lidocaine (6 mg/kg) on tone...

Progressive electrical alternans followed by conduction block and fibrillatory have been suggested to precede disorganization of atrial flutter (Afl) fibrillation (AF). The purpose the present study was investigate patterns local repolarization in high low right atrium determine site with pronounced propensity action potential during Afl AF.Combination pacing/recording contact monophasic (MAP) catheters were utilized evaluate from upper endocardium 16 pigs. To induce sustained or (AF),...

Ranolazine has been found to prevent ventricular arrhythmias (VAs) during acute myocardial infarction (AMI). This study aimed investigate its efficacy on VAs induced several days post-MI. For this purpose, 13 anesthetized rabbits underwent coronary artery ligation. Ten of these animals that survived AMI were reanesthetized 3 7 later for electrophysiologic testing. An endocardial monophasic action potential combination catheter was placed in the right ventricle simultaneous pacing and...

Journal Article Monoclonal antibodies specific for human cardiac myosin: selection, characterization and experimental myocardial infarct imaging Get access E. HOBERG, HOBERG Search other works by this author on: Oxford Academic PubMed Google Scholar M. EISENHUT, EISENHUT *Abteilung für Nuklearmedizin, University of HeidelbergHeidelberg, West Germany HOFMANN, HOFMANN G. SCHULER, SCHULER J. BRACHMANN, BRACHMANN I. AIDONIDIS, AIDONIDIS NACHTKAMP, NACHTKAMP W. KÜBLER, KÜBLER H. A. KATUS European...

The effects of i.v. diltiazem (0.25 mg/kg) and verapamil (0.15 were studied in 18 patients with recurrent paroxysmal supraventricular tachycardia (SVT) who underwent serial electrophysiological studies. In 10 extranodal accessory pathways the similar comparable plasma concentrations. SVT was prevented 10/10 cases after 9/10 verapamil, furthermore there as an increase antegrade refractoriness normal AV nodal pathway 22 27%, respectively; conduction remained unchanged both drugs. 8 dual...

The effects of the two calcium antagonists bepridil and nifedipine on induced ventricular tachyarrhythmias were studied by programmed electrical stimulation in 15 dogs, 4–8 days after myocardial infarction. Recordings from infarcted normal anterior wall left ventricle obtained with an epicardial implanted 'composite' electrode. Bepridil (5 mg/kg) or (0.025 administered i.v. different testing was repeated. Sustained tachycardia prevented significantly slowed 11/12 experiments compared none 9...

Summary The effects of prenylamine (PNL) and AQ-A 39 on sustained ventricular tachycardia (SVT) were studied by programmed stimulation in conscious dogs 4–10 days after ligation the left anterior descending (LAD) coronary artery. In 8 16 developing SVT control, PNL (3 mg/kg intravenously, i.v.) suppressed in-ducibility slowed rate 6 other animals. a separate group 10 with inducible SVT, (4 abolished elicitation 3 decreased its dogs. Neither drug affected normal conduction significantly, but...

The aim of the present study was to investigate effect lidocaine (L) on ventricular tachyarrhythmias with special reference fibrillation (VF). Myocardial infarction (MI) created in 39 dogs by doubly ligating left anterior descending (LAD) coronary artery. All animals surviving (n = 33) were subjected programmed stimulation 7.6 ± 3.2 days later. Local electrical activity recorded from subepicardium wall means a specially designed composite electrode. L (2 and 4 mg/kg i.v.) facilitated...