A5043316821- Restless Legs Syndrome Research
- Dialysis and Renal Disease Management
- Parkinson's Disease Mechanisms and Treatments
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Sleep and Wakefulness Research
- Muscle and Compartmental Disorders
- Sports Performance and Training
- Exercise and Physiological Responses
- Cardiomyopathy and Myosin Studies
- Sleep and related disorders
- Adipose Tissue and Metabolism
- Bipolar Disorder and Treatment
- Muscle activation and electromyography studies
- Injury Epidemiology and Prevention
- Nutrition and Health in Aging
- Sleep and Work-Related Fatigue
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Byzantine Studies and History
- Sports injuries and prevention
- Heart Rate Variability and Autonomic Control
- Obstructive Sleep Apnea Research
- Physical Activity and Health
- Electrolyte and hormonal disorders
University of Thessaly
2016-2025
National and Kapodistrian University of Athens
2007-2023
Plymouth Marjon University
2016-2021
Center for Research and Technology Thessaly
2008-2019
Centre for Research and Technology Hellas
2013-2019
University of California, San Francisco
2003-2007
Manchester Metropolitan University
1999-2001
Applied BioPhysics (United States)
2001
Troponin senses Ca 2+ to regulate contraction in striated muscle. Structures of skeletal muscle troponin composed TnC (the sensor), TnI regulator), and TnT link the thin filament) have been determined. The structure -activated state features a nearly twofold symmetrical assembly subunits penetrated asymmetrically by dumbbell-shaped subunit. ions are thought controlling presentation withdrawal inhibitory segment from filament. Here, we show that rigid central helix sensor binds state....
Abstract Background Restless Legs Syndrome is very common in hemodialysis patients however there are no comparative studies assessing the effectiveness of a non-pharmacological treatment to classical on parameters related syndromes’ severity and quality life. Methods In this randomized, partially double blind, placebo controlled trial, thirty two with restless legs syndrome were randomly assigned into three groups: 1) exercise training group (N = 16), 2) dopamine agonists (ropinirole 0.25...
Uraemic restless legs syndrome (RLS) affects a significant proportion of patients receiving haemodialysis (HD) therapy. Exercise training has been shown to improve RLS symptoms in uraemic patients; however, the mechanism exercise-induced changes severity is still unknown. The aim current randomized controlled exercise trial was investigate whether reduction severity, often seen after training, due expected systemic adaptations or it mainly relief that leg movements confer during on cycle...
We present the first study on influence of exercise training restless legs syndrome (RLS) in patients hemodialysis (HD). Restless has been treated pharmacologically with satisfactory results; however, side effects and rebound phenomena have reported. Intradialytic effectively counteracts uremia-induced catabolism; nevertheless, it remains unknown whether RLS undergoing HD benefit from such programs. The aims current were to evaluate effect 16-weeks aerobic severity functional capacity...
The mechanisms responsible for the inhibition of shortening velocity that occurs during muscle fatigue have not been completely elucidated. Phosphorylation myosin regulatory light chain (RLC) heavy use; however, previous reports on its role in affecting equivocal. To further understand process fatigue, we varied levels RLC phosphorylation (from 10 to >50%) and concentrations protons pH 7 6.2) phosphate 5 30 mM), all which change fatigue. We measured mechanics permeable rabbit psoas fibers at...
Background Restless Legs Syndrome is a very common disorder in hemodialysis patients. negatively affects quality of life; however it not clear whether this due to mental or physical parameters and an association exists between the syndrome affecting survival. Methodοlogy/Principal Findings Using criteria presence Periodic Limb Movements Sleep (PLMS/h >15), 70 clinically stable patients were assessed divided into RLS (n = 30) non-RLS 40) groups. Physical performance was evaluated by battery...
Optimal hemodialysis (HD) dose is very important to patients' health and survival, various indices of adequacy have been incorporated into the current clinical practice monitor HD efficiency. Exercise during could facilitate solute removal; however, it still unknown whether prolonged intradialytic exercise further improve Ten stable "high-functioning" patients volunteered participate. The were studied under two scenarios HD: 1) supine (cycling) for 3 hours at 40% maximum capacity 2) no as...
Background/Objectives: Manual massage is an effective treatment approach for reducing general stress and promoting overall sense of well-being. Relaxation aims to alleviate psychophysiological tension, enhance both blood lymphatic circulation, promote mental physical relaxation. It particularly beneficial those with anxiety-related symptoms (such as generalized anxiety disorder social anxiety) sleep disorders, aiming improve calmness sleepiness. Aims: The purpose the present study was assess...
Changes in high-energy phosphate levels single human skeletal muscle fibres after 10 s of maximal (all-out) dynamic exercise were investigated. Muscle biopsies from vastus lateralis two volunteers collected at rest and immediately post exercise. Single dissected dry assigned into one four groups according to their myosin heavy chain (MyHC) isoform content: that is type I, IIA, IIAx IIXa (the latter containing either less or more than 50% IIX MyHC). Fragments characterised analysed by HPLC...
In hemodialysis (HD) patients, restless legs syndrome (RLS) and periodic limb movements in sleep (PLMS) constitute common disorders. Recent findings indicate a role for PLMS as risk factor the development of new or aggravation existing cardiovascular disease. The aim current study was to investigate association with indices cardiac morphology function HD patients RLS potential pathway by which could alter risk.Based on diagnosis an overnight polysomnographic evaluation, 19 stable HD-RLS were...
Skeletal muscle dysfunction is common in chronic kidney disease (CKD). Of interest the concept of “muscle quality,” which measures include ultrasound-derived echo intensity (EI). Alternative parameters texture, for example, gray level co-occurrence matrix (GCLM), are available and may circumvent limitations EI. The validity EI limited humans, particularly diseases. This study aimed to investigate associations between texture with MRI. Images thigh were acquired using a 3 Tesla MRI scanner....
Restless legs syndrome (RLS) is very common in hemodialysis patients. RLS induces motor excitability and discomfort during rest periods, those symptoms have also been observed sessions. The aim of the study was to assess whether a single bout exercise could reduce periodic limb movements (PLM) occurring hemodialysis. Eighteen patients were eligible participated study. Using criteria further verified by presence PLM sleep, divided non-RLS groups. Three scenarios studied three different...
OPINION article Front. Physiol., 31 July 2012 | https://doi.org/10.3389/fphys.2012.00306
Both exercise training and treatment with dopamine agonists (DA) have been used success for the amelioration of uremic restless legs syndrome (RLS) symptoms. However, no data are available combining those two approaches. The aim current randomized, double-blind, placebo-controlled study was to investigate effects a 6 month intradialytic in combination low dose DA patients suffering from RLS Fourteen stable on hemodialysis were randomly assigned plus group placebo group. combinations found...