A5021866018- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Bone health and osteoporosis research
- Cardiac Ischemia and Reperfusion
- Bone Metabolism and Diseases
- Veterinary Pharmacology and Anesthesia
- Cardiac electrophysiology and arrhythmias
- Nanoparticle-Based Drug Delivery
- Traumatic Brain Injury and Neurovascular Disturbances
- Osteoarthritis Treatment and Mechanisms
- Anesthesia and Neurotoxicity Research
- Natural product bioactivities and synthesis
- Acute Kidney Injury Research
- Trauma Management and Diagnosis
- Vector-borne infectious diseases
- Animal testing and alternatives
- Erythropoietin and Anemia Treatment
- Total Knee Arthroplasty Outcomes
- Birth, Development, and Health
- Pharmacological Effects of Natural Compounds
- Anesthesia and Sedative Agents
- Neonatal and fetal brain pathology
- Bone health and treatments
- Phytoestrogen effects and research
- Dermatological diseases and infestations
National and Kapodistrian University of Athens
2015-2024
University of Crete
2023
Foundation for Research and Technology Hellas
2023
New York University Press
2021
Cambridge University Press
2021
Biomedical Research Foundation of the Academy of Athens
2014-2021
General Hospital of Attica
2014-2021
Academy of Athens
2013-2018
Hellenic Cardiological Society
2015
Observing and reporting clinical signs in laboratory animals is necessary for many reasons: the assessment of animal welfare, compliance with principle refinement (e.g. humane endpoints), regulatory severity) and, importantly, as a scientific outcome, e.g. models disease or safety studies. Developments will enhance value gained from experiments further address ethical cost. This paper discusses systematic approaches to observation (to be) used research. Glossaries public corporate...
Sudden cardiac death (SCD) is a field of continuous research. In order to answer various questions regarding SCD, several animal models have been developed. The aim the present study describe our experimental model inducing arrest in Landrace/Large White pigs, and then resuscitated according International Guidelines on resuscitation. Fifteen pigs were anaesthetized intubated while spontaneously breathing. left right jugular veins, as well femoral carotid arteries, surgically prepared....
The Journal of Orthopaedic Research, a publication the Research Society (ORS), is forum for rapid high quality reports new information on full spectrum orthopaedic research, including life sciences, engineering, translational, and clinical studies.
Background Aim of this experimental study was to compare haemodynamic effects and outcome with early administration amiodarone adrenaline vs. alone in pigs prolonged ventricular fibrillation (VF). Methods After 8 min untreated VF arrest, bolus doses were administered (0.02 mg/kg) either (5 or saline (n = per group) after randomisation. Cardiopulmonary resuscitation (CPR) commenced immediately drug administration, defibrillation attempted 2 later. CPR resumed for another each attempt, the...
Platelet-rich fibrin (PRF) is a relatively new developed platelet concentrate with several benefits over platelet-rich plasma. The aim of this study was to compare healing properties PRF and its combination ceramic synthetic material (graft) composed hydroxyapatite b-tricalcium phosphate in an animal model.A bone deficit surgically created each femoral condyle 15 New Zealand white rabbits. In animal, 1 limb had (a) only the other (b) plus graft randomly implanted. Experimental animals were...
Background: Cardiac arrest remains the leading cause of death in Western societies. Advanced Life Support guidelines propose epinephrine (adrenaline) for its treatment. The aim this study was to assess whether a calcium sensitizer agent, such as levosimendan, administered combination with during cardiopulmonary resuscitation, would improve initial resuscitation success. Methods: Ventricular fibrillation induced 20 Landrace/Large‐White piglets, and left untreated 8 min. Resuscitation then...
IGF-1 is one of the key molecules in cancer biology; however, little known about role preferential expression premature isoforms prostate cancer. We have examined cleaved COO− terminal peptide (PEc) third isoform, IGF-1Ec, Our evidence suggests that endogenously produced PEc induces cellular proliferation human cells (PC-3) vitro and vivo, by activating ERK1/2 pathway an autocrine/paracrine manner. overexpressing tumors presented epithelial to mesenchymal transition, whereas orthotopic...
Effects of dietary Corinthian currants on atherosclerosis, oxidative stress and plasma phenolic compounds in hypercholesterolemic animal models.
We propose and implement an experimental protocol for in vivo testing of implantable antennas rats, which aims to quantify dependence the exhibited resonance performance upon antenna size intersubject surgical procedure variability. Two with occupied volumes 204 399 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> are tested inside three different rats each. Investigations carried out Medical Implant Communications Service (MICS) band...
In Brief Objective: The aim of this study was to investigate the potential protective effect Sideritis euboea extract (SID), commonly consumed as "mountain tea," on bone mineral density (BMD) and strength ovariectomized (OVX) rat model osteoporosis. Methods: Thirty-two 10-month-old Wistar rats were separated into controls (sham operated), OVX, OVX plus SID in their drinking water (dose, 330 mg/kg body weight per day), starting immediately after for 6 months. Tibial BMD at baseline 3 months...
The aim of this study was to evaluate the potential effect methanolic extract plant Glycyrrhiza glabra roots on bone mineral density and femoral strength ovariectomized rats.Thirty 10-month-old Wistar rats were randomly separated into three groups ten, Control, Ovariectomy Ovariectomy-plus-Glycyrrhiza in their drinking water. Total proximal tibial measured all before ovariectomy (baseline) after 3 6 months post ovariectomy. Three-point-bending femurs uterine weight histology examined at end...
The objective of this study was to evaluate and compare the complications cardiopulmonary resuscitation after manual or mechanical chest compressions in a swine model ventricular fibrillation. In retrospective study, 106 were treated with either (n=53) LUCAS device (n=53). All cadavers underwent necropsy. animals no autopsy findings significantly fewer group (P=0.004). Sternal fractures identified 18 only two (P=0.003). Rib present 16 four (P=0.001). Nine manual, had liver hematomas...
Objective: The aim of this study is to describe and evaluate an experimental model neonatal normocapnic hypoxia resuscitation. Methods: Ten male Landrace/Large White piglets were studied. Following anaesthesia intubation, the animals mechanically ventilated. Surgical procedures included catheterization right internal jugular vein carotid artery. After stabilization with 21% O2, was induced by decreasing inspired O2 6–8%. When developed bradycardia (heart rate < 60 beats/min), reoxygenation...