A5024483658- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Cancer Diagnosis and Treatment
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Cancer Risks and Factors
- HER2/EGFR in Cancer Research
- Cervical Cancer and HPV Research
- Cancer-related cognitive impairment studies
- Bone health and treatments
- Cancer survivorship and care
- Genomic variations and chromosomal abnormalities
- Cancer Treatment and Pharmacology
- Pharmaceutical Practices and Patient Outcomes
- Testicular diseases and treatments
- Reproductive Biology and Fertility
- Tumors and Oncological Cases
- Music Therapy and Health
IASO General Hospital
2020-2024
LETO Maternity Hospital
2022-2023
Senologic Hellenic Society
2023
Metropolitan Hospital
2021
National and Kapodistrian University of Athens
2014-2017
University General Hospital Attikon
2011-2013
Data on the effectiveness and safety of approved SARS-CoV-2 vaccines in cancer patients are limited. This observational, prospective cohort study investigated humoral immune response to vaccination 232 from 12 HeCOG-affiliated oncology departments compared 100 healthcare volunteers without known active cancer. The seropositivity rate was measured 2–4 weeks after two vaccine doses, by evaluating neutralising antibodies against spike protein using a commercially available immunoassay....
Our aim was to evaluate the concordance between Myriad MyChoice and two alternative homologous recombination deficiency (HRD) assays (AmoyDx HRD Focus NGS Panel OncoScan™) in patients with epithelial ovarian cancer (EOC). Tissue samples from 50 newly diagnosed EOC known status were included. DNA aliquots tumor samples, previously evaluated centrally reassessed, distributed laboratories assess their using platforms, after being blinded for CDx status. The primary endpoint each assay. Tumor an...
Background: Hereditary cancer predisposition syndromes are responsible for approximately 5–10% of all diagnosed cases. In order to identify individuals at risk in a cost-efficient manner, family members carrying pathogenic alterations tested only the specific variant that was identified their carrier relative. The purpose this study investigate clinical use and implementation cascade testing (CFT) families breast patients with pathogenic/likely variants (PVs/LPVs) cancer-related genes....
<h3>Abstract</h3> Background/Aim: Germline copy number variation (CNV) is a type of genetic variant that predisposes significantly to inherited cancers. Today, next-generation sequencing (NGS) technologies have contributed multi gene panel analysis in clinical practice. Materials and Methods: A total 2,163 patients were screened for cancer susceptibility, using solution-based capture method. 52 genes was used targeted NGS. The capture-based approach enables computational CNVs from NGS data....
Cancer-related fatigue (CRF) is a common distressing complaint of breast cancer (BC) patients treated with chemotherapy. Nutritional quality plays pivotal role in CRF, while increased interest towards new pharmacological agents has been observed. Melatonin, an endogenous hormone that regulates the human sleep-wake cycle, could alleviate CRF. In present randomized, placebo-controlled 3-month trial, we investigated effects melatonin intake (i.e., 1 mg/day) vs. placebo BC on both arms,...
ABSTRACT: Our objective was to investigate the impact of methotrexate, paclitaxel, ifosfamide, and cisplatin (M‐TIP) on long‐term fertility in poor‐risk nonseminomatous germ cell tumors (NSGCT). Thirty patients with NSGCT (median age, 29 years; range, 17–62 years) were treated methotrexate 250 mg/m 2 folinic acid rescue (day 1) paclitaxel 175 1), followed by ifosfamide 1.2 g/m 20 (days 2–6). Treatment consisted 4 cycles M‐TIP administered every 3 weeks. Twenty‐one continuously disease‐free...
Recognizing resistance or susceptibility to the current standard cisplatin and paclitaxel treatment could improve therapeutic outcomes of metastatic recurrent cervical cancer. Forty-five tissue samples from patients participating in a phase II trial ifosfamide, with without were collected for retrograde analysis. Immunohistochemistry genotyping was performed test ERCC1, III β-tubulin, COX-2, CD4, CD8 ERCC1 (C8092A N118 N) MDR1 (C3435T G2677 T) gene polymorphisms, as possible predictive...
The oral problems of 24 cancer patients on immunotherapy between 2017–2022 and referred by their oncologists, were reported. age range was 49–80 years, the median 64 years. Lung most common disease. Three a had history autoimmune disease prior to diagnosis. Patients received for two 48 months. Prior immunotherapy, 17 cytotoxic chemotherapy, five angiogenesis inhibitors one1 radiotherapy head/neck. During four one bevacizumab, eight bone targeting agents, either alone or in combination....
Classification of splicing variants (SVs) in genes associated with hereditary cancer is often challenging. The aim this study was to investigate the occurrence SVs and clinical utility RNA analysis.1518 individuals were tested for predisposition, using a Next Generation Sequencing (NGS) panel 36 genes. Splicing variant analysis performed RT-PCR Sanger Sequencing.In total, 34 different identified, 53% which classified as pathogenic or likely pathogenic. remaining 16 initially Variant...
Abstract The primary aim of this randomized controlled trial pilot was to investigate the potential effectiveness music psychotherapy method, Guided Imagery and Music (GIM), assist female patients who are undergoing chemotherapy treatment for breast or gynecologic cancer. A secondary suggest performance improvements regarding protocol resources required undertake a future larger scale study. researchers participants (n = 20) into two groups: Intervention group 10) Control 10). received...
e12524 Background: Although it has long been hypothesized that the use of antibiotics may increase risk breast cancer, through effects on inflammation, immunity and gastrointestinal microflora alter metabolism phytochemicals, clinical data this association are sparse. Methods: Matched case-control study among 158 women with newly diagnosed primary invasive cancer from a single unit age-matched controls (± 12 months) healthy individuals accompanying patients to outpatient clinics between...
3146 Background: Homologous recombination deficiency (HRD) in ovarian cancer, indicative of impaired DNA repair, contributes to genomic instability (GIS). Beyond mutations BRCA1/2 genes, GIS is particularly significant for identifying patients who may benefit from PARP inhibitors. Equivalence between Myriad Genetics' myChoice CDx and the standard diagnostic tests OncoScan Amoy Diagnostics has been published, prompting HeSMO launch a national program addressing BRCA 1/2 newly diagnosed...
Early-onset breast cancer constitutes a major criterion for genetic testing referral. Nevertheless, studies focusing on patients (≤30 years) are limited. We investigated the contribution and spectrum of known breast-cancer-associated genes in 267 Greek women with ≤30 years while monitoring their clinicopathological characteristics outcomes. In this cohort, significant proportion (39.7%) carried germline pathogenic variants (PVs) distributed 8 genes. The majority, namely 36.7%, involved...
Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) and adjuvant is a therapeutic choice for women with advanced ovarian cancer. Whether NACT affects the tumor's molecular profile has not been determined.
A 59-year-old male presented with a painful right inguinal swelling and deep vein thrombosis at the ipsilateral leg. An hernia was initially diagnosed, but during surgery large mass found anteriorly to peritoneal sheaths. Histology revealed high-grade pleomorphic rhabdomyosarcoma. The advanced rapidly, occupying whole iliac fossa metastasizing lung. Despite first- second-line chemotherapy, patient deteriorated rapidly died. Rhabdomyosarcomas should be managed in specialized centres as they...