A5031247244- Advanced Data Storage Technologies
- Cancer Genomics and Diagnostics
- Caching and Content Delivery
- BRCA gene mutations in cancer
- Distributed systems and fault tolerance
- Parallel Computing and Optimization Techniques
- Genomics and Rare Diseases
- Cloud Computing and Resource Management
- Thyroid Disorders and Treatments
- Distributed and Parallel Computing Systems
- Glioma Diagnosis and Treatment
- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Peripheral Neuropathies and Disorders
- DNA Repair Mechanisms
- Classical Antiquity Studies
- Peer-to-Peer Network Technologies
- IPv6, Mobility, Handover, Networks, Security
- Histiocytic Disorders and Treatments
- Balance, Gait, and Falls Prevention
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Digestive system and related health
- Tumors and Oncological Cases
- Interconnection Networks and Systems
- Advancements in Semiconductor Devices and Circuit Design
Nottingham University Hospitals NHS Trust
2024-2025
Athens Medical Center
2023-2024
National Centre of Scientific Research "Demokritos"
2021-2024
Institute of Nuclear & Radiological Sciences and Technology, Energy & Safety
2021
Sigint Solutions (Cyprus)
2020
Panagiotis & Aglaia Kyriakou Children's Hospital
2010-2013
Intel (United States)
2007-2011
Intel (United Kingdom)
2010
University of Rochester
2003-2005
Foundation for Research and Technology Hellas
1998-2001
During concurrent I/O workloads, sequential access to one stream can be interrupted by accesses other streams in the system. Frequent switching between multiple may severely affect efficiency due long disk seek and rotational delays of disk-based storage devices. Aggressive prefetching improve granularity data such cases, but it comes with a higher risk retrieving unneeded data. This paper proposes competitive strategy that controls depth so overhead switch unnecessary are balanced. The...
Background: Hereditary cancer predisposition syndromes are responsible for approximately 5–10% of all diagnosed cases. In order to identify individuals at risk in a cost-efficient manner, family members carrying pathogenic alterations tested only the specific variant that was identified their carrier relative. The purpose this study investigate clinical use and implementation cascade testing (CFT) families breast patients with pathogenic/likely variants (PVs/LPVs) cancer-related genes....
Altered linezolid pharmacokinetics (PK) in obese individuals has been hypothesized previous studies. However, specific dosing recommendations for this population are still lacking. The main goal of study was to evaluate PK/pharmacodynamic (PKPD) target attainment when using a 600 mg intravenous q12h dose against MRSA patients with pneumonia. Fifteen pneumonia confirmed or suspected involvement treated were studied 3 days. Population PK modelling used characterize the variability and screen...
Treatment with thyroxine in children chronic autoimmune thyroiditis (AT) is controversial. The aim of this study to investigate, by using thyroid ultrasonography, whether influences volume non-goitrous euthyroid AT.We studied 50 and adolescents AT for 2 years function tests ultrasonography; 25 were randomized receive did not treatment. Median (IQR) age was 12.1 (11.1-13.2) years.At baseline there no difference SDS between the two groups (treatment group 1.1 (0.7-1.5) controls 0.9 (0.4-1.4),...
Use condition inputs to physics-of-failure models are required use knowledge-based qualification of ICs. Modern CPUs have multiple voltage-frequency states which vary widely in reliability stress, but it is not obvious what time the various product qualification. We present a methodology for developing state model combines large scale user monitoring and lab-based studies. Results specific CPU family, including field validation implications qualification, discussed.
Type 1 diabetes (T1DM) is associated with gastric autoimmunity, which characterized by the presence of parietal cell antibodies (APCA). We investigated autoimmunity prevalence in T1DM children, its manifestations, determinants and association thyroid gland (anti-Tg, anti-TPO) pancreatic β-cell (anti-GAD) at baseline 4 years later.The initial cohort (D1) included 97 children T1DM. At follow-up after (D2), 84.5% participants were evaluated. assessed APCA, anti-Tg, anti-TPO, anti-GAD presence,...
We have discovered that processors can experience a super-linear increase in detected unrecoverable errors (DUE) when the write-back L2 cache is doubled size. This paper explains how an tag's Architectural Vulnerability Factor or AVF caused such DUE rate. expresses fraction of faults become user-visible errors. Our hypothesis this by ¿dirty¿ data residence times cache. Using proton beam irradiation, we measured rates from tags and analyzed to show our holds. utilized combination simulation...
During concurrent I/O workloads, sequential access to one stream can be interrupted by accesses other streams in the system. Frequent switching between multiple may severely affect efficiency due long disk seek and rotational delays of disk-based storage devices. Aggressive prefetching improve granularity data such cases, but it comes with a higher risk retrieving unneeded data. This paper proposes competitive strategy that controls depth so overhead switch unnecessary are balanced. The...
This paper describes a mechanism allowing nodes to hand-off active connections by utilizing connection splicing at an edge-switch serving as gateway server cluster. The is primarily intended be used part of content aware request distribution strategy. Our approach uses extended form network address translation which maps inbound information (ie., address, port, and sequence number) separate outbound connection. A key difference in our that while the switch performs TCP splicing, actual...
Implementation of next-generation sequencing (NGS) for the genetic analysis hereditary diseases has resulted in a vast number variants identified daily, leading to inadequate variant interpretation and, consequently, lack useful clinical information treatment decisions. Herein, we present MARGINAL 1.0.0, machine learning (ML)-based software rare BRCA1 and BRCA2 germline variants. classifies into three categories, namely, (likely) pathogenic, uncertain significance benign, implementing...
Although transactions have been a valuable abstraction of atomicity, persistency, and recoverability, they not widely used in programming environments today, mostly because their high overheads that driven by the low performance magnetic disks. A major challenge transaction-based systems is to remove disk from critical path transaction management. We present PERSEAS, library for main memory databases decouples speed. Our system based on layer reliable provides fast recoverable storage data....
Early-onset breast cancer constitutes a major criterion for genetic testing referral. Nevertheless, studies focusing on patients (≤30 years) are limited. We investigated the contribution and spectrum of known breast-cancer-associated genes in 267 Greek women with ≤30 years while monitoring their clinicopathological characteristics outcomes. In this cohort, significant proportion (39.7%) carried germline pathogenic variants (PVs) distributed 8 genes. The majority, namely 36.7%, involved...
The application of next-generation sequencing (NGS) technology in the genetic investigation hereditary cancer is important for clinical surveillance, therapeutic approach, and reducing risk developing new malignancies. aim study was to explore predisposition individuals referred cancer.
Abstract Background and purpose Myelin oligodendrocyte glycoprotein (MOG) antibody‐associated disease (MOGAD) is a relatively recently described disease, most commonly presenting with optic neuritis longitudinally extensive transverse myelitis. Cerebral cortical encephalitis rare manifestation of MOGAD. Methods We identified patients cerebral positive MOG antibodies in serum across large specialized service. Demographic clinical information were collected. describe laboratory...