A5017407002- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Economic and Financial Impacts of Cancer
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Estrogen and related hormone effects
- Gastric Cancer Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Lung Cancer Treatments and Mutations
- Ovarian cancer diagnosis and treatment
- Cancer survivorship and care
- Cancer Risks and Factors
- Advanced Breast Cancer Therapies
- Advanced Database Systems and Queries
- Cancer Diagnosis and Treatment
University of Ioannina
2010-2025
University Hospital of Ioannina
2004-2024
Hellenic Society for the Study of Bone Metabolism
2019-2024
Hellenic Cooperative Oncology Group
2006-2024
Technological Educational Institute of Central Greece
2009-2024
Sherman Oaks Hospital
2020
Redmond Fire Department
2020
Park Plaza Hospital
2020
Hospital Agioi Anargyroi
2020
Senologic Hellenic Society
2020
BAFF (BLyS, TALL-1, THANK, zTNF4) is a member of the TNF superfamily that specifically regulates B lymphocyte proliferation and survival. Mice transgenic (Tg) for develop an autoimmune condition similar to systemic lupus erythematosus. We now demonstrate Tg mice, as they age, secondary pathology reminiscent Sjögren's syndrome (SS), which manifested by severe sialadenitis, decreased saliva production, destruction submaxillary glands. In humans, SS also correlates with elevated levels...
Herpes simplex virus (HSV) 1 and 2 infect activated T lymphocytes by attachment of the HSV envelope glycoprotein D (gD) to cellular herpesvirus entry mediator (HVEM), an orphan member tumor necrosis factor receptor superfamily. Here, we demonstrate that HVEM binds two ligands, secreted lymphotoxin α (LTα) LIGHT, a new TNF LIGHT is 29 kDa type II transmembrane protein produced cells also engages for LTαβ heterotrimer but does not form complexes with either LTα or LTβ. HSV1 gD inhibits...
BAFF (BLyS, TALL-1, THANK, zTNF4) is a member of the TNF superfamily that specifically regulates B lymphocyte proliferation and survival. Mice transgenic (Tg) for develop an autoimmune condition similar to systemic lupus erythematosus. We now demonstrate Tg mice, as they age, secondary pathology reminiscent Sjögren’s syndrome (SS), which manifested by severe sialadenitis, decreased saliva production, destruction submaxillary glands. In humans, SS also correlates with elevated levels...
Toll-like receptor 4 (TLR4), the signal-transducing molecule of LPS complex, plays a fundamental role in sensing from gram-negative bacteria. Activation TLR4 signaling pathways by is critical upstream event pathogenesis sepsis, making an attractive target for novel antisepsis therapy. To validate concept TLR4-targeted treatment strategies we first showed that TLR4(-/-) and myeloid differentiation primary response gene 88 (MyD88)(-/-) mice were fully resistant to Escherichia coli-induced...
Abstract To investigate how T cells are involved in hypersensitivity reactions to drugs that become immunogenic after metabolization, e.g., sulfonamides and antiepileptics, we analyzed vitro the drug-induced activation of CD4+ CD8+ cell subsets, cytokine secretion, TCR V beta distribution, proliferation from four drug-allergic individuals. In addition, parameters CD25 HLA-DR were vivo on five patients with acute drug allergies, some them anticonvulsant syndrome hepatitis. Our results show...
<h3>Objective</h3> To evaluate the effect of high-dose intravenous immunoglobulin (IVIG) in toxic epidermal necrolysis (TEN), parameters that may affect response to treatment, and different IVIG batches on Fas-mediated cell death. <h3>Design</h3> Multicenter retrospective analysis 48 consecutive TEN patients treated with IVIG. <h3>Setting</h3> Fourteen university hospital dermatology centers Europe United States. <h3>Patients</h3> Forty-eight (skin detachment >10% their body surface...
Abstract The TNF ligand family member B cell-activating factor belonging to (BAFF, also called Blys, TALL-1, zTNF-4, or THANK) is an important survival for cells. In this study, we show that BAFF able regulate T cell activation. rBAFF induced responses (thymidine incorporation and cytokine secretion) of cells, suboptimally stimulated through their TCR. activity was observed on naive, as well effector/memory cells (both CD4+ CD8+ subsets), indicating has a wide function responses. Analysis...
Multiple-treatments meta-analyses are increasingly used to evaluate the relative effectiveness of several competing regimens. In some fields which evolve with continuous introduction new agents over time, it is possible that in trials comparing older newer regimens latter exaggerated. Optimism bias, conflicts interest and other forces may be responsible for this exaggeration, but its magnitude impact, if any, needs formally assessed each case. Whereas such novelty bias not identifiable a...
To investigate CD40 signaling complex formation in living cells, we used green fluorescent protein (GFP)-tagged intermediates and confocal life imaging. The majority of cytoplasmic TRAF2-GFP and, to a lesser extent, TRAF3-GFP, but not TRAF1-GFP or TRAF4-GFP, translocated into complexes within few minutes after triggering with the ligand. inhibitor apoptosis proteins cIAP1 cIAP2 were also recruited by TRAF2 sites signaling. An excess allowed recruitment signaling, whereas an TRAF1 abrogated...
To clarify on a molecular level the specific T cell response to haptens like penicillin G, we generated lines and clones from penicillin-allergic patients. Two types of beta-lactam reactivity cells could be delineated: one group patients showed rather restricted specificity, as penicillin-elicited such donors proliferated only stimulating penicillin, but not other antibiotics nor cephalosporines, even if side chain was identical. This indicates that penicilloyl structure together with...