A5085601430- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Blood Coagulation and Thrombosis Mechanisms
- RNA Research and Splicing
- Cell death mechanisms and regulation
- Prostate Cancer Treatment and Research
- Cell Adhesion Molecules Research
- RNA and protein synthesis mechanisms
- Acute Myeloid Leukemia Research
- Cancer-related Molecular Pathways
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- RNA Interference and Gene Delivery
- Lymphoma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Cancer Mechanisms and Therapy
- Multiple Myeloma Research and Treatments
- Renal cell carcinoma treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
National and Kapodistrian University of Athens
2016-2025
Vrije Universiteit Brussel
2023
Aristotle University of Thessaloniki
2015
University of Patras
2015
Yale University
2014
University General Hospital Attikon
2009-2014
Technical University of Munich
2004-2013
Bipar
2013
Faculty (United Kingdom)
2013
National Centre of Scientific Research "Demokritos"
2001-2010
The disturbance of apoptosis molecular signaling pathways is involved in carcinogenesis. BCL2 family proteins the hallmark regulation. In last decade, new members gene were discovered and cloned found to be differentially expressed many types cancer. protein family, through its role regulation apoptotic pathways, possibly related cancer pathophysiology resistance conventional chemotherapy. It well known that leukemias are haematopoietic malignancies characterized by biological diversity,...
Programmed death-ligand 1 (PD-L1; also known as CD274 or B7-H1) expression represents a mechanism of immune escape for cancer. Our purpose was to characterize tumor PD-L1 and associated T-cell infiltration in primary laryngeal squamous cell carcinomas (SCC).A well-annotated cohort 260 operable SCCs [formalin-fixed paraffin-embedded (FFPE) specimens] morphologically characterized stromal tumor-infiltrating lymphocytes (TIL), on hematoxylin/eosin-stained whole sections mRNA by qRT-PCR FFPE...
Matrix metalloprotease-9 (MMP-9; 92 kDa type IV collaganase, gelatinase B) is regarded as, important for degradation of the basement membrane and extracellular matrix during cancer invasion other tissue-remodelling events. In this study we evaluate prognostic value MMP-9, by immunoperoxidase staining in a series 210 breast tissues. The results were quantitated using HSCORE system, which consider both intensity percentage cells stained at given intensities. MMP-9 status was compared with...
Purpose: The discovery of new ovarian cancer biomarkers that are suitable for early disease diagnosis and prognosis may ultimately lead to improved patient management outcomes. Patients Methods: We measured, by immunoassay, human kallikrein 6 (hK6) concentration in serum 97 apparently healthy women, 141 women with benign abdominal diseases, 146 histologically proven primary carcinoma. then calculated the diagnostic sensitivity specificity this test examined association hK6 various...
Over 90% of cancer-related deaths in clear cell renal carcinoma (RCC) are caused by tumor relapse and metastasis. Thus, there is an urgent need for new molecular markers that can potentiate the efficacy current clinical-based models prognosis assessment. The objective this study to evaluate potential significance lactate dehydrogenase A (LDHA), assessed immunohistochemical staining, as a prognostic marker relation clinicopathological features clinical outcome. We expression LDHA at protein...
miRNAs are small, nonprotein coding RNAs that differentially expressed in many malignancies. We previously identified 80 dysregulated clear cell renal carcinoma. In this study we validated over expression of the miR-17-92 cluster carcinoma and tested effect 2 members (miR-17-5p miR-20a) on tumor proliferation. also elucidated role miRNA pathogenesis with bioinformatics.miRNA was by quantitative reverse transcriptase-polymerase chain reaction. The proliferation miR-17-5p miR-20a a...
Article21 January 2019Open Access Source DataTransparent process The lysine-specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer Theodoros Rampias orcid.org/0000-0002-5460-5334 Biomedical Research Foundation Academy of Athens, Greece Search for more papers by this author Dimitris Karagiannis orcid.org/0000-0002-4394-1076 Margaritis Avgeris orcid.org/0000-0002-2135-9886 Department Biochemistry and Molecular Biology, Faculty National Kapodistrian University Alexander...
Coronavirus SARS-CoV-2, the causative agent of COVID-19, has caused a still evolving global pandemic. Given worldwide vaccination campaign, understanding vaccine-induced versus COVID-19-induced immunity will contribute to adjusting vaccine dosing strategies and speeding-up efforts.Anti-spike-RBD IgGs neutralizing antibodies (NAbs) titers were measured in BNT162b2 mRNA vaccinated participants (n = 250); we also investigated humoral cellular immune responses individuals 21) this cohort 5...
Kallikrein gene 5 (KLK5, also known as KLK-L2), located on chromosome 19q13.4, is one of the newly identified members kallikrein family, which a subgroup serine protease enzyme family. In normal human tissues, KLK5 highly expressed in skin, mammary gland and testis. Preliminary RT-PCR analysis has indicated that subset ovarian tumours. We have thus hypothesized may be new prognostic indicator cancer. examined mRNA expression 142 malignant tissues. Tumours were pulverized, total RNA was...
The human kallikrein locus on chromosome 19q13.3–13.4 contains 1 – the tissue and 14 related serine proteases. Recent investigations into their function evolution have indicated that present nomenclature for these proteins is inadequate or insufficient. Here we a new in which without proven kininogenase activity are denoted kallikrein-related peptidase. Names also given to unique rodent closely 1.