A5074505919- Renal and related cancers
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Genetic and Kidney Cyst Diseases
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Acute Kidney Injury Research
- Immunotherapy and Immune Responses
- Central Venous Catheters and Hemodialysis
- Nutrition, Genetics, and Disease
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Chromatin Remodeling and Cancer
- Peptidase Inhibition and Analysis
- MRI in cancer diagnosis
- Biomedical Text Mining and Ontologies
- Cancer Immunotherapy and Biomarkers
- Cardiac Arrest and Resuscitation
- Angiogenesis and VEGF in Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
Osaka University
2020
The University of Melbourne
2019
Royal Children's Hospital
2019
University of Toronto
2011-2017
Mount Sinai Hospital
2012-2016
St. Michael's Hospital
2009-2014
Bipar
2013
Queen's University
2012
Sunnybrook Health Science Centre
2012
Renal cell carcinoma is the most common neoplasm of adult kidney. Currently to our knowledge there are no biomarkers for diagnostic, prognostic or predictive applications renal carcinoma. miRNAs nonprotein coding RNAs that negatively regulate gene expression and potential cancer.We analyzed 70 matched pairs clear normal kidney tissues from same patients by microarray analysis validated results quantitative real-time polymerase chain reaction. We also performed extensive bioinformatic explore...
Over 90% of cancer-related deaths in clear cell renal carcinoma (RCC) are caused by tumor relapse and metastasis. Thus, there is an urgent need for new molecular markers that can potentiate the efficacy current clinical-based models prognosis assessment. The objective this study to evaluate potential significance lactate dehydrogenase A (LDHA), assessed immunohistochemical staining, as a prognostic marker relation clinicopathological features clinical outcome. We expression LDHA at protein...
MicroRNAs (miRNAs) play a crucial role in tumor progression and metastasis. We, others, recently identified number of miRNAs that are dysregulated metastatic renal cell carcinoma compared with primary carcinoma. Here, we investigated three significantly downregulated tumors: miR-192, miR-194 miR-215. Gain-of-function analyses showed restoration their expression decreases migration invasion line models, whereas knockdown these resulted enhancing cellular abilities. We targets potential...
miRNAs are small, nonprotein coding RNAs that differentially expressed in many malignancies. We previously identified 80 dysregulated clear cell renal carcinoma. In this study we validated over expression of the miR-17-92 cluster carcinoma and tested effect 2 members (miR-17-5p miR-20a) on tumor proliferation. also elucidated role miRNA pathogenesis with bioinformatics.miRNA was by quantitative reverse transcriptase-polymerase chain reaction. The proliferation miR-17-5p miR-20a a...
Renal cell carcinoma (RCC) is the most common neoplasm of kidney. We conducted an integrated analysis copy number, gene expression (mRNA and miRNA), protein expression, methylation changes in clear renal (ccRCC). used a stepwise approach to identify significant number aberrations (CNA) identified regions peak broad gain loss, including gains (3q21, 5q32, 5q34-q35, 7p11, 7q21, 8q24, 11q13, 12q14) deletions (1p36, 2q34-q37, 3p25, 4q33-q35, 6q23-q27, 9p21). These harbor novel tumor-related...
Kallikrein-related peptidases (KLKs) are a family of serine proteases that have been shown to be dysregulated in several malignancies including ovarian cancer. The control kallikrein genes and their physiological function cancer is not well understood. We hypothesized microRNAs (miRNAs) represent novel mechanism for post-transcriptional KLK expression cancer.We first analysed miRNA silico. A total 98 miRNAs were reported altered Three these predicted target KLK10. experimentally verified the...
Abstract Purpose The clinical implications of biallelic inactivation CDKN2A/B in clear cell renal carcinoma (ccRCC) and relevant dysregulated biological pathways gene signatures were investigated. Materials Methods Data obtained from the TCGA data set validated using Project GENIE previously published dataset. allelic status was classified into 3 groups, including (homozygous deletion or combined heterozygous mutation), monoallelic loss (heterozygous mutation) absent loss. Univariate...
Abstract Hereditary Breast and Ovarian Cancer Sydrome (HBOC) accounts for approximately 5-10% of breast ovarian cancer cases germline mutations the BRCA1 BRCA2 genes confer substantially increased risk. However, risk developing cancer, type associated age at diagnosis vary depending on mutation carried individual's ethnic background gender. Screening was conducted 5, 512 high-risk individuals with a prior probability carrying pathogenic (>10% chance) from Advanced Molecular...
385 Background: miRNAs play a crucial rule in tumor progression and metastasis. We previously identified miR-192, miR-194 miR-215 to be down-regulated metastatic compared primary clear cell renal carcinoma (ccRCC). In this work, we examine the role of miR-194, RCC aggressiveness. Methods: examined these three on migration invasion abilities using line models. performed target prediction analysis experimentally validated targets independent approaches. addition, clinical utility as potential...
<h3>Background</h3> There is a critical need for collaborative measures between Canadian institutions to better facilitate variant analysis and data sharing. <h3>Objectives</h3> The Open Genetics Repository (COGR) effort the collection, sharing of variants reported by medical diagnostics laboratories across Canada. project focuses on reaching consensus agreements classification among clinical through disseminating such information large, public repository. <h3>Design/method</h3> COGR...