A5069540452- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Adrenal and Paraganglionic Tumors
- Radiopharmaceutical Chemistry and Applications
- Cerebral Palsy and Movement Disorders
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Intracranial Aneurysms: Treatment and Complications
- Adipose Tissue and Metabolism
- Muscle activation and electromyography studies
- Vascular Malformations Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Bone health and osteoporosis research
- Lymphoma Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Patient-Provider Communication in Healthcare
- Advanced Radiotherapy Techniques
- Head and Neck Surgical Oncology
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Radiology practices and education
Twin Cities Orthopedics
1988-2023
University of Minnesota
1988-2023
North American Skull Base Society
2023
University of Minnesota System
2023
University of Minnesota Medical Center
2021
Mayo Clinic in Arizona
2020
Mayo Clinic
2017-2018
WinnMed
2017
Abstract We developed a nano-antibody targeted chemotherapy (nATC) delivery strategy in which tumor specific and clinically relevant antibodies (rituximab, anti-CD20) are non-covalently bound to the albumin scaffold of nab-paclitaxel (ABX). define nanoparticle formed when 2 drugs (AR160). The newly created nATC retains cytotoxicity ABX CD20 affinity rituximab vitro . describe binding characteristics AR160 using peptide mapping/Biacore approach. Flow-based methods, including ImageStream...
Abstract In patients with metastatic melanoma, high blood levels of galectin‐9 are correlated worse overall survival and a bias towards Th2 inflammatory state supportive tumor growth. Although signaling through TIM3 on T cells has been described, less is known about the interaction macrophages. We aimed to determine whether binding partner CD206 macrophages result this tumor‐supportive. It was determined that incubation CD68 + or anti‐CD206 blocked target both were detected by...
Antibody directed chemotherapy (ADC) takes advantage of the selectivity monoclonal antibody to increase efficacy chemotherapeutic agent, while reducing toxicity. Previously we described three nab-paclitaxel (Abraxane) nanoparticles coated with commercial antibodies. Identifying binding sites responsible for these particles could allow reverse engineering antibodies, creating a modular platform nanoparticles. Herein, Biacore surface plasmon resonance is used identify an site, HSA Peptide 40,...
Background Pituitary apoplexy after resection of giant pituitary adenomas is a rare but often cited morbidity associated with devastating outcomes. It presents as hemorrhage and/or infarction residual tumor in the postoperative period. Because its rarity, incidence and consequences remain ill defined. Objective The aim this study to estimate rate assess mortality apoplexy. Methods A systematic review literature was performed examine extent based on surgical approach, apoplexy, morbidities,...
INTRODUCTION: Racial disparities in treatment and outcomes disproportionately affect patients of color many surgical fields. There is limited research on these within the field neurosurgery most studies report solely outcomes, not management, populations at a single institution. METHODS: The National Cancer Institute Surveillance, Epidemiology, End Results database (1971-2015) was used to collect demographic clinical variables with meningioma (n = 63674), glioblastoma 35258), pituitary...
INTRODUCTION: Disparities in outcomes disproportionately affect minority populations many surgical fields. In contrast, racial disparities decision-making remains an enigma due to the difficulty capturing surgeon recommendations during initial patient workup. METHODS: The odds of recommendation against resection at diagnosis primary brain neoplasms was determined using multivariable logistic regression with clinical, demographic, and socioeconomic factors. A dual registry analysis designed...
Introduction: Disparities in healthcare may affect patients that differ by age, gender, race, ethnicity, and insurance status among other characteristics. Disparity research is often focused on how patient factors (e.g., status) or institution-specific size/volume at institution) contribute to differential outcomes; however, little known about provider-specific a surgeon's recommendation) effects disparities delivery. Provider-specific are difficult study due challenges capturing surgeon...
<h3>Background</h3> Antibody-drug conjugates (ADC) increase the efficacy of current chemotherapeutics, decrease off site toxicity, and pair drug function with immunomodulatory effects. Current ADC platforms depend on use covalent linker molecules between antibody choice. This approach leads to significant variation in number bound, location their binding, inconsistency maintaining structure antigen affinity antibody. Because this, covalent-based development requires extensive separation...