A5007856380- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Mycobacterium research and diagnosis
- Colorectal Cancer Surgical Treatments
- Helicobacter pylori-related gastroenterology studies
- Clinical Laboratory Practices and Quality Control
- Gastrointestinal disorders and treatments
- COVID-19 and healthcare impacts
- Gut microbiota and health
- Health disparities and outcomes
- Pharmaceutical Practices and Patient Outcomes
- Pancreatic and Hepatic Oncology Research
- Iron Metabolism and Disorders
- Esophageal Cancer Research and Treatment
- Health Promotion and Cardiovascular Prevention
- Lipoproteins and Cardiovascular Health
- COVID-19 Clinical Research Studies
- Lung Cancer Diagnosis and Treatment
- Empathy and Medical Education
- Patient-Provider Communication in Healthcare
- Renal function and acid-base balance
- Metabolism, Diabetes, and Cancer
University of Surrey
2013-2025
Royal Surrey NHS Foundation Trust
2012-2021
Public Health England
2015-2021
Bowel Cancer UK
2012-2019
Royal Surrey County Hospital
1995-2017
Royal London Hospital
2011
University Hospitals Coventry and Warwickshire NHS Trust
2011
University College London
2011
Imperial College London
2011
St Luke's Hospital
1995
Population-based screening for early detection and treatment of colorectal cancer (CRC) precursor lesions, using evidence-based methods, can be effective in populations with a significant burden the disease provided services are high quality. Multidisciplinary, guidelines quality assurance CRC diagnosis have been developed by experts project co-financed European Union. The 450-page were published book format Commission 2010. They include 10 chapters over 250 recommendations, individually...
Background An organized, population-based, colorectal cancer screening programme was initiated in England 2006 offering biennial faecal occult blood testing (FOBT) to adults aged 60–69 years. Organized programmes with no associated financial costs the individual should minimize barriers access for lower socio-economic status (SES) groups. However, SES differences uptake were observed pilot centres of UK programme, so aim this analysis identify extent inequalities by SES, ethnic diversity,...
The National Health Service Bowel Cancer Screening Programme (BCSP) in England uses a guaiac-based faecal occult blood test (gFOBt). A quantitative immunochemical (FIT) for haemoglobin (Hb) has many advantages, including being specific human blood, detecting Hb at much lower concentration with single sample and improved uptake.In 2014, large comparative pilot study was performed within BCSP to establish the acceptability diagnostic performance of FIT. Over 6-month period, 40 930 (1 28)...
The trial aimed to investigate whether a general practitioner's (GP) letter encouraging participation and more explicit leaflet explaining how complete faecal occult blood test (FOBT) included with the England Bowel Cancer Screening Programme invitation materials would improve uptake. A randomised controlled 2 × factorial was conducted in south of England. Overall, 1288 patients registered 20 GPs invited for screening October 2009 participated trial. Participants were either GP's endorsement...
Uptake in the national colorectal cancer screening programme England varies by socioeconomic status. We assessed four interventions aimed at reducing this gradient, with intention of improving health benefits screening.
<h3>Objective</h3> To examine patterns of colorectal cancer (CRC) screening uptake over three biennial invitation rounds in the National Health Service (NHS) Bowel Cancer Screening Programme (BCSP) England. <h3>Methods</h3> We analysed data from BCSP9s Southern Hub for individuals (n=62 099) aged 60–64 years at time first to with a follow-up period that allowed two further invitations. Data on sex, age and neighbourhood-level measure socioeconomic deprivation were used analysis. Outcomes...
Multidisciplinary, evidence-based guidelines for quality assurance in colorectal cancer screening and diagnosis have been developed by experts a project coordinated the International Agency Research on Cancer. The full guideline document covers entire process of population-based screening. It consists 10 chapters over 250 recommendations, graded according to strength recommendation supporting evidence. 450-page extensive evidence base published European Commission. chapter faecal occult...
In the UK, patients with one or two adenomas, of which at least is ≥ 10 mm in size, three four small are deemed to be intermediate risk colorectal cancer (CRC) and referred for surveillance colonoscopy 3 years post polypectomy. However, costly, can cause discomfort carries a complications.
Objective New screening tests for colorectal cancer (CRC) are rapidly emerging. Conducting trials with mortality reduction as the end point supporting their adoption is challenging. We re-examined principles underlying evaluation of new non-invasive in view technological developments and identification biomarkers. Design A formal consensus approach involving a multidisciplinary expert panel revised eight previously established principles. Results Twelve newly stated emerged. Effectiveness...
Faecal occult blood testing (FOBT) in population screening has proved to be effective reducing mortality from colorectal cancer. In Italy a latex agglutination FOBT been adopted for single-sample programme. The aim of this study was examine the performance FOBTs Florence programme over several seasons evaluate impact variations ambient temperature on test.Measured haemoglobin (Hb) concentrations were aggregated into with their average (AAT). Using logistic regression, AAT period preceding...
Objective The English Bowel Cancer Screening Programme (BCSP) recommends 3 yearly colonoscopy surveillance for patients at intermediate risk of colorectal cancer (CRC) postpolypectomy (those with three to four small adenomas or one ≥10 mm). We investigated whether faecal immunochemical tests (FITs) could reduce burden on and endoscopy services. Design Intermediate-risk (60–72 years) recommended were recruited within the BCSP (January 2012–December 2013). FITs offered 1, 2 years...
Bowel cancer is a serious health burden and its early diagnosis improves survival. The Cancer Screening Programme (BCSP) in England screens with the Faecal Occult Blood test (FOBt), followed by colonoscopy for individuals positive result. Socioeconomic inequalities have been demonstrated FOBt uptake, but it not known whether they persist at next stage of screening pathway. aim this study was to assess association between uptake area socioeconomic deprivation, controlling individual age sex,...
The aim was to use newly available data estimate the cost effectiveness and endoscopy requirements of screening options for colorectal cancer (CRC) inform policy in England.A state transition model simulated life experience a cohort individuals general population England with normal colon/rectal epithelium through development adenomas CRC subsequent death. natural history parameters test characteristics were estimated simultaneously by process calibration. This fitted observed on incidence...
The faecal immunochemical test (FIT) is replacing the guaiac occult blood in colorectal cancer screening. Increased uptake and FIT positivity will challenge colonoscopy services. We developed a risk prediction model combining routine screening data with concentration to improve accuracy of referrals. Multivariate analysis used complete cases those positive (⩾20 μg g−1) diagnostic outcome (n=1810; 549 cancers advanced adenomas). Logistic regression was develop using result data: age, sex...
Objectives Through the National Health Service (NHS) Bowel Cancer Screening Programme (BCSP), men and women in England aged between 60 74 years are invited for colorectal cancer (CRC) screening every 2 using guaiac faecal occult blood test (gFOBT). The aim of this analysis was to estimate cost–utility immunochemical haemoglobin (FIT) compared with gFOBT a cohort beginning at range FIT positivity thresholds. Design We constructed cohort-based Markov state transition model CRC disease...
There is a socioeconomic gradient in the uptake of screening English NHS Bowel Cancer Screening Programme (BCSP), potentially leading to inequalities outcomes. We tested whether endorsement bowel cancer by an individual's general practice (GP endorsement; GPE) reduced this gradient. A cluster-randomised controlled trial. Over 20 days, individuals eligible for England from 6480 participating practices were randomly allocated receive GP-endorsed or standard invitation letter. The primary...