A5090056264- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Acute Lymphoblastic Leukemia research
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Global Cancer Incidence and Screening
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Neuroendocrine Tumor Research Advances
- Inflammatory Bowel Disease
- Microscopic Colitis
- Diverticular Disease and Complications
- Chemotherapy-induced cardiotoxicity and mitigation
- Lung Cancer Research Studies
- Ovarian cancer diagnosis and treatment
- Brain Metastases and Treatment
- Hematopoietic Stem Cell Transplantation
- Testicular diseases and treatments
- Mycobacterium research and diagnosis
- Medical Imaging and Pathology Studies
- Multiple Myeloma Research and Treatments
- Advanced Breast Cancer Therapies
Karolinska Institutet
2015-2025
Stockholm South General Hospital
2002-2025
Hamilton Health Sciences
2024
Svenska Örtmedicinska Institute
2021
Stockholm County Council
2018-2019
Radboud University Nijmegen
2018
Radboud Institute for Molecular Life Sciences
2018
Radboud University Medical Center
2018
Region Västra Götaland
2018
Karolinska University Hospital
2007-2017
Population-based screening for early detection and treatment of colorectal cancer (CRC) precursor lesions, using evidence-based methods, can be effective in populations with a significant burden the disease provided services are high quality. Multidisciplinary, guidelines quality assurance CRC diagnosis have been developed by experts project co-financed European Union. The 450-page were published book format Commission 2010. They include 10 chapters over 250 recommendations, individually...
Adriamycin has been found effective in metastatic osteogenic sarcoma. To determine its efficacy osteosarcoma without detectable metastases, 21 patients were given adjuvant adriamycin therapy two weeks (median) after surgical amputation of the primary lesion. Six courses (30 mg per square meter daily for three days, repeated every four to six weeks) administered. Nineteen survived from more than one 32 months (median, nine months) operation. Five relapsed (two with local and pulmonary...
A prospective randomized trial was conducted comparing the clinical response of 78 previously untreated patients with advanced metastatic breast cancer to a combination cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) or adriamycin, (CAF). Sixty-two percent receiving CMF responded treatment compared an 82% rate for CAF. Although within acceptable limits, hematologic GI toxicity greater There no significant difference in duration two regimens. Therefore, therapeutic between therapies...
A randomized trial of combined modality therapy employing combination chemotherapy (cyclophosphamide (CTX) and methotrexate (MTX), CTX, MTX Vincristine (VCR) VCR high-dose with citrovorum rescue) radiation was compared to cyclophosphamide in 258 patients pulmonary small cell carcinoma. Patients were also randomized: 1) determine the effects prophylactic whole brain irradiation; 2) establish maintenance chemotherapy. Survival, frequency response site relapse different limited disease (LD)...
Streptozotocin was administered to 106 patients with advanced malignancies. Therapeutic responses were observed in Hodgkin's disease, 7/16, lymphocytic lymphoma, 3/11, Burkitt's 1/12, and acute leukemia, 1/5. Two of 7 islet cell carcinoma, 1 insulin-secreting serotonin-secreting, responded, but 8 malignant carcinoid tumors originating from the ileum failed demonstrate a reduction either urinary 5-hydroxyindole acetic acid or tumor mass. Additional evidence drug activity 2 melanoma cases...
Objective Participation, an indicator of screening programme acceptance and effectiveness, varies widely in clinical trials population-based colorectal cancer (CRC) programmes. We aimed to assess whether CRC participation rates can be compared across organized guaiac fecal occult blood test (G-FOBT)/fecal immunochemical (FIT)-based programmes, what factors influence these rates. Methods Programme representatives from countries participating the International Cancer Screening Network were...
Importance Population-based colorectal cancer (CRC) screening programs are implemented worldwide, but there difficulties evaluating their effectiveness. The magnitude of routine CRC effectiveness regarding cancer-specific mortality is unclear. Objective To evaluate associated with early vs late or no invitation for using fecal occult blood testing. Design, Setting, and Participants This prospective cohort study was performed in the region Stockholm-Gotland, Sweden, between January 1, 2008,...
Twenty-four patients with non-Hodgkin's lymphoma and CNS involvement are presented. There were 7 cases diffuse histiocytic (HL), 9 poorly differentiated lymphocytic (PDLL-D), of whom 6 in leukemic conversion, 5 nodular (PDLL-N), 3 undifferentiated (UL). complications noted only Stage IV lymphoma; the prognosis was generally poor. Histiocytic associated widespread parenchymatous infiltration, whereas PDLL usually leptomeningeal seeding. The clinical course neuropathologic findings discussed.
The records of 29 patients with Hodgkin's disease involving the lung were reviewed to determine pathologic features involvement, diagnostic and prognostic significance radiographic manifestations clinical course after involvement was recognized. Twenty-six had nodular sclerosing disease, a frequency far in excess relative this particular cell type population from which selected. In all who not previously received anterior mediastinal radiation or systemic chemotherapy, hilar adenopathy...
Summary Small non-coding RNAs have emerged as possible biomarkers for various diseases including autoimmune diseases. A number of studies demonstrated that the expression specific microRNAs (miRNAs) is dysregulated in rheumatoid arthritis (RA). So far, all on miRNAs RA patients been performed using either microarray or reverse transcription–quantitative polymerase chain reaction (RT–qPCR) analyses. Compared to RT–qPCR and analyses, next-generation sequencing (NGS) allows genome-wide analysis...
Three hundred twenty-six patients with acute myelocytic leukemia were randomly and prospectively assigned to four therapeutic regimens: cytosine arabinoside either alone or in combination daunorubicin, 6-mercaptopurine, 6-thioguanine. The results 231 qualified previously untreated analyzed. treatments produced a significantly greater frequency of complete partial remission than single drug therapy. Treatment thioguanine led 48% ageadjusted responses. median survival from diagnosis all 66...
In a study of 117 patients under the age 20 with acute leukemia, vincristine (VCR), at 2 mg. per square meter body surface week, produced complete remissions in 55 cent and partial 15 cent. The drug also induced second remissions. Patients entering remission VCR were randomly allocated to maintenance therapy or placebo. median duration was short: 9 weeks for compared 6 probability serious neurological toxicity computed according time exposure VCR, based on supposition that not used therapy,...
To evaluate compliance by age, gender, and screening round in the population based Stockholm/Gotland colorectal cancer programme.All individuals aged between 60 69 living counties of Stockholm Gotland (Sweden) have, since 2008, successively been included a programme using biennial faecal occult blood tests (Hemoccult®). Personal invitations including test kits have sent to home addresses, with positive result called defined clinic for an assessment colonoscopy. Descriptive statistics used...
•This prospective cohort study provides updated estimates on risk of small bowel cancer in IBD.•In patients with CD, the relative was 8.3 for adenocarcinoma and 3.5 neuroendocrine tumors.•Patients UC had a twofold increased tumors.•The absolute excess malignancy IBD does not motivate active surveillance. BackgroundUncertainty prevails about magnitude inflammatory disease (IBD).Patients methodsTo quantify tumors ulcerative colitis (UC) Crohn's (CD), we undertook population-based all diagnosed...
Abstract One hundred and seven patients with carcinoma of the lung underwent immunologic testing, 62 these were randomized to an immunotherapy protocol comparing effects Pasteur strain BCG, either alone or combined allogeneic tumor cells, no immunotherapy. Patients residual disease left at time surgery metastatic diagnosis showed increase in survival as a result this form An insufficient number less advanced disease, whom we would expect most beneficial effect, have been entered study. In...
Forty-five patients with advanced squamous cell carcinoma of the head and neck, 23 whom had received no prior therapy, were given combination vinblastine, 4 mg/m2 intravenously (IV) on Day 1; bleomycin, 15 mg/day intramuscularly Days 1-7; cis-diamminedichloroplatinum (II), 60 mannitol diuresis 8. The regimen was repeated at three-week intervals, for a maximum three cycles. Among without surgery or radiation, there 5 complete responses 12 partial responses, 74% response rate; whereas, among...
Seven patients with multiple myeloma who developed a second neoplasm are presented. There were four acute leukemia and three non-hematologic neoplasms. The among the longest survivors (median duration ≈ 72 months) response to anti-leukemic therapy in these was generally poor. Of neoplasms, one patient observed simultaneous renal cell carcinoma other two adenocarcinoma of colon lung subsequently. In addition, mammary subsequently included. Literature reviewed possibility that itself might be...