A5058989984- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
- Inflammatory Bowel Disease
- Esophageal Cancer Research and Treatment
- Nutrition and Health in Aging
- Gastrointestinal motility and disorders
- Global Cancer Incidence and Screening
- Colorectal and Anal Carcinomas
- Muscle metabolism and nutrition
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Eosinophilic Esophagitis
- Urinary and Genital Oncology Studies
- Social and Educational Sciences
- Diet and metabolism studies
- Health Promotion and Cardiovascular Prevention
- Dysphagia Assessment and Management
- Bariatric Surgery and Outcomes
- Migration, Refugees, and Integration
- Diversity and Career in Medicine
Karolinska Institutet
2016-2025
Saint Göran Hospital
2024
Lund University
2024
Skåne University Hospital
2024
Karolinska University Hospital
1997-2023
Immune Therapy Holdings (Sweden)
2018
1. A method is described enabling the determination of fat, water, electrolytes, protein, DNA, RNA and total creatine in a single sample human muscle obtained by percutaneous needle-biopsy technique. The amino acid content can also be analysed same sample. 2. Fifty healthy subjects were studied: 29 between 19 40 years age, 11 41 60 10 61 85 age. two groups aged less than showed only marginal differences composition, whereas highest age group increases fat relation to tissue weight decreases...
BERGH, U., B. SJÖDIN, A. FORSBERG, and J. SVEDENHAG. The relationship between body mass oxygen uptake during running in humans. Med. Sci. Sports Exerc., Vol 23, No. 2, pp. 205–211, 1991. Oxygen treadmill was measured at submaximal maximal intensities six different groups of endurance athletes (N = 134) seven endurance-trained men. (M) (VO2) evaluated by deriving the exponent b equation VO2 a.Mb. Thus, if 1, increases proportion to per kg is independent mass; b<1, then inversely related mass....
Objective The ethiopathogenesis of irritable bowel syndrome (IBS) is unknown. While a link to the gut microbiome postulated, heterogeneity healthy makes it difficult draw definitive conclusions. We aimed describe faecal and mucosa-associated (MAM) health correlates on community cohort IBS individuals with no colonoscopic findings. Design PopCol study recruited random sample 3556 adults; 745 underwent colonoscopy. was defined by Rome IV criteria organic disease excluded. 16S rRNA gene...
Abstract Colorectal cancer (CRC) incurs a significant disease burden globally. Organised CRC screening programmes have been widely implemented for early detection and prevention. To understand the public health impact of these programmes, quantitative evidence changes in overall age-specific population incidences is fundamental. We aimed to provide such by exploiting time lag implementation organised Sweden: two out 21 regions (these comprise nearly 20% total Swedish population) offered...
The pathogenesis of gastroesophageal reflux disease (GERD) is multifactorial, including the mechanical anti-reflux barrier junction. This can be evaluated endoscopically in two ways: by measuring axial length any hiatal hernia present or assessing flap valve. endoscopic measurement troublesome because physiological dynamics area. Grading valve easier and has proven reproducible. aim study was to compare grading methods with regard associations GERD.Population-based subjects underwent...
ABSTRACT Background Whether uncomplicated diverticulosis gives rise to symptoms is controversial. Diary‐based studies of abdominal pain and stool habits in general populations are scarce, we therefore investigated symptom patterns from prospectively collected diaries a random sample the population who completed research colonoscopy. Methods In Swedish population‐based colonoscopy (PopCol) study, 745 individuals underwent which 130 had diverticulosis, none diverticulitis. Seven‐day were by...
Objective. There are few prospective studies of the prevalence colonic neoplasia in normal population. In order to properly evaluate screening-protocols for colorectal cancer risk groups (e.g., older subjects or those with a family history), it is essential know adenomas and Methods. A population-based colonoscopy study on 745 individuals born Sweden aged 19–70 years was conducted (mean age 51.1 years). All polyps seen were retrieved examined. Results. Out 27% had polyps, regardless kind....
In Western countries the prevalence of Helicobacter pylori (H. pylori) infection may be declining but there is a lack recent longitudinal population studies. We evaluated changing epidemiology over 23-year period in Sweden.In 1989, validated Abdominal Symptom Questionnaire (ASQ) was mailed to random sample inhabitants (ages 22-80 years) Swedish community, and 1097 (87%) responded. H. serology analysed representative subsample (n = 145). Twenty-three years later, ASQ again using similar...
Obesity is a risk factor for colorectal cancer (CRC).The objective of this article to investigate whether anthropometric measures reflecting visceral obesity are better predictors CRC than body mass index (BMI).Data were analysed from the Malmö Diet and Cancer study in Sweden, comprising 16,669 women 10,805 men (median age 56.6 59.1 years) followed median 21.5 years. Diagnoses identified using Swedish national registers. Cox regression was used test associations BMI, waist circumference...
Background & AimsThe rate of postcolonoscopy colorectal cancer (PCCRC) is a measure colonoscopy quality, but there are conflicting results from studies survival times patients with PCCRC. We assessed PCCRC and characterized the microscopic macroscopic features tumors.MethodsWe performed population-based cohort study using data database in Sweden, on 458,937 colonoscopies (54.0% women) 2003 through 2012. Rates within 3 years were calculated based World Endoscopy Organization guidelines. Risk...
The etiopathogenesis of diverticular disease is unknown.To compare the fecal and mucosa-associated microbiota between participants with without diverticulosis who later developed diverticulitis versus those that did not from a population-based study.The PopCol study, conducted in Stockholm, Sweden, invited random sample 3556 adults to participate, which 745 underwent colonoscopy. Overall, 130 (17.5%) had diverticulosis. 16S rRNA gene sequencing was on available sigmoid biopsy samples 529 251...
Surveillance guidelines for the management of familial colorectal cancer (FCC), a dominant family history in which polyposis syndromes and Lynch syndrome have been excluded, are not firmly established. The outcome colonoscopic surveillance is studied using data from six centers. DNA mismatch repair deficiency was excluded by genetic testing. Families were classified as FCC type X if they fulfilled original Amsterdam criteria (AC) late onset (LOFCC) AC apart having aged under 50. most...
The rates for colonoscopy-associated adverse events vary considerably worldwide. In Sweden, the figures are known to a limited extent. We assessed frequency of severe colonoscopy-related and impacts different risk factors, including use general anaesthesia.This is retrospective population-based cohort study colonoscopies performed during years 2001-2013 on adults identified in Swedish health registers. bleeding, perforation, splenic injury 30-day mortality were calculated. Covariates risks...
We have addressed health equity attained by fecal immunochemical testing (FIT) and primary colonoscopy (PCOL), respectively, in the randomised controlled screening trial SCREESCO conducted Sweden.We analysed data on individuals recruited between March 2014, 2020, within study registered with ClinicalTrials.gov, NCT02078804. Swedish population registry educational level, household income, country of birth, marital status were linked to each 60-year-old man woman who had been two rounds FIT 2...
Colonoscopy quality, including lesion detectability, is variable, and factors influencing detection are not fully understood. This study investigated rates during colonoscopies the associated in SCREEning of Swedish COlons (SCREESCO) study.In this cross-sectional analysis data from SCREESCO, a large-scale randomized controlled trial colorectal cancer screening population aged 60 years, we assessed first-time performed both colonoscopy fecal immunochemical test (FIT) arms.This included 16 552...
Objective Post-colonoscopy colorectal cancer (PCCRC), a occurring within short interval of colonoscopy, might be partly explained as missed or incompletely resected lesions. Associated risk factors are age, sex, comorbidity, location, and colonoscopy volume. There is gap in the knowledge prevalence PCCRC impact different Sweden. Methods This retrospective population-based observational cohort study colonoscopies performed on adults during years 2001–2010 that were identified from Swedish...
We hypothesized that the prevalence of functional dyspepsia and gastroesophageal reflux disease in community may be increasing.Randomly selected adults were surveyed on 4 occasions: 1988 (n = 1,151, 21-79 years, response rate [rr] 90%), 1989 1,097, 22-80 rr 87%), 1995 1,139, 20-85 76%), 2011 1,175, 20-93 63%).In dyspepsia, odds postprandial distress syndrome tripled over 23 years' follow-up (odds ratio [OR]: 3.55; 95% confidence interval [CI]: 2.60-4.84, mixed-effect regression analysis),...
Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC). In order to detect CRCs amongst LS patients, regular colonoscopies are recommended. However, an international agreement on optimal surveillance interval has not yet been reached. addition, few studies have investigated factors that could potentially increase CRC risk patients.The primary aim was describe frequency detected during endoscopic and estimate from a clean colonoscopy detection patients. The...
The clinical relevance of small to moderate sliding hiatal hernias is controversial. aims the present study were (1) investigate which symptoms are associated with and (2) define length a hernia at gastrointestinal occur.A population representative general Swedish answered questionnaire regarding was investigated an upper endoscopy. any measured.Only reflux-related (acid regurgitation OR 1.46, CI 1.19-1.79, heartburn 1.27, 1.05-1.54), association did not become significant until axial 2...