A5044666621- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Inflammatory Bowel Disease
- Microscopic Colitis
- Hernia repair and management
- Gastroesophageal reflux and treatments
- Appendicitis Diagnosis and Management
- Radiology practices and education
- Intestinal and Peritoneal Adhesions
- Esophageal and GI Pathology
- Pelvic and Acetabular Injuries
- Intestinal Malrotation and Obstruction Disorders
- Photoacoustic and Ultrasonic Imaging
- Congenital Diaphragmatic Hernia Studies
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Global Cancer Incidence and Screening
- Gastrointestinal motility and disorders
- Genetic factors in colorectal cancer
- Radiation Dose and Imaging
- Anorectal Disease Treatments and Outcomes
- Advanced X-ray and CT Imaging
University College London
2016-2025
University College Hospital
2014-2025
Royal London Hospital
2022-2025
University College London Hospitals NHS Foundation Trust
2016-2024
Medical College of Wisconsin
2024
Creative Commons
2023
Imperial College London
2023
Imperial College Healthcare NHS Trust
2023
Guy's and St Thomas' NHS Foundation Trust
2023
King's College London
2023
These consensus guidelines were jointly commissioned by the British Society of Gastroenterology (BSG), Association Coloproctology Great Britain and Ireland (ACPGBI) Public Health England (PHE). They provide an evidence-based framework for use surveillance colonoscopy non-colonoscopic colorectal imaging in people aged 18 years over. are first that take into account introduction national bowel cancer screening. For time, they also incorporate patients following resection either adenomatous or...
Anatomical models are important training and teaching tools in the clinical environment routinely used medical imaging research. Advances segmentation algorithms increased availability of three-dimensional (3D) printers have made it possible to create cost-efficient patient-specific without expert knowledge. We introduce a general workflow that can be convert volumetric data (as generated by Computer Tomography (CT)) 3D printed physical models. This process is broken up into three steps:...
Magnetic resonance enterography (MRE) and ultrasound are used to image Crohn's disease, but their comparative accuracy for assessing disease extent activity is not known with certainty. Therefore, we did a multicentre trial address this issue.
Unlike hospital-based clinicians, general practitioners (GPs) lack direct contact with radiologists, and the radiology report is usually sole method of communication from radiologist to GP. It important gain feedback regarding what GPs perceive as a good-quality report, especially in current climate competition for provision services. The aims this study are determine level GP satisfaction reports, their perception optimum content preferences detail format. A questionnaire was sent 100...
Main recommendations 1 ESGE/ESGAR recommend computed tomographic colonography (CTC) as the radiological examination of choice for diagnosis colorectal neoplasia.Strong recommendation, high quality evidence. do not barium enema in this setting.Strong 2 CTC, preferably same or next day, if colonoscopy is incomplete. The timing depends on an interdisciplinary decision including endoscopic and factors.Strong low suggests that, centers with expertise availability colon capsule endoscopy (CCE),...
ESGE European Society of Gastrointestinal Endoscopy FIT fecal immunochemical test FOBT occult blood testing GRADE Grading Recommendations Assessment, Development and Evaluation NPV negative predictive value PEG polyethylene glycol PPV positive This is an official guideline the (ESGE) Abdominal Radiology (ESGAR), published in simultaneously.It addresses clinical indications for use computed tomographic colonography (CTC).A targeted literature search was performed to evaluate evidence...
Purpose To assess the repeatability in human volunteers of software-quantified small bowel motility captured with magnetic resonance (MR) imaging and to test ability detect changes induced by pharmacologic agents. Materials Methods The study was approved Royal Free Research Ethics Committee, all subjects gave full written informed consent. Twenty-one healthy (14 men, seven women; mean age, 28 years) underwent cine MR a three-dimensional balanced turbo field-echo sequence capture motility....
To determine if a new photoacoustic imaging (PAI) system successfully depicts (1) peripheral arteries and (2) microvascular circulatory changes in response to thermal stimuli. Following ethical permission, 8 consenting subjects underwent PAI of the dorsalis pedis (DP) artery, 13 completed index fingertip. Finger images were obtained after immersion warm (30-35 °C) or cold (10-15 water promote vasodilation vasoconstriction. The instrument used Fabry-Perot interferometeric ultrasound sensor...
Purpose To evaluate the accuracy of MRI-quantified small bowel motility for Crohn disease activity against endoscopic and histopathologic reference standards. Materials Methods For this prospective study, 82 participants (median age, 31 years; range, 16 to 70 42 males [median 17 years] 40 females 63 years) underwent colonoscopy MR enterography within 14 days (from October 2011 March 2014) at two centers. The index severity (CDEIS), score (endoscopic biopsy acute histologic inflammatory...
LBA3504 Background: The prognostic advantage of early stage deficient-MMR/MSI-High colorectal cancer (CRC) is lost after relapse. Hence, there a clinical imperative to maximise the chance cure in early-stage disease. Tumour mutation burden (TMB) an emerging biomarker for response and benefit immunotherapy advanced setting. NEOPRISM-CRC (Neoadjuvant PembRolizumab In Stratified Medicine – ColoReCtal) first multicentre Phase II Trial determine if neoadjuvant pembrolizumab efficacious safe,...
Summary Background Magnetic resonance enterography ( MRE ) can measure small bowel motility, reduction in which reflects inflammatory burden Crohn's Disease CD ). However, it is unknown if motility improves with successful treatment. Aim To determine changes segmental reflect response to anti‐ TNF α therapy after induction and longer term. Methods A total of 46 patients (median 29 years, 19 females) underwent before treatment; 35 identified retrospectively repeat median 55 weeks treatment 11...
Abstract Background Chronic intestinal pseudo‐obstruction ( CIPO ) is characterized by dilatation of the bowel lumen and abnormal motility. In this study, we aimed to quantify small dysmotility in using a validated pan‐intestinal motility assessment technique based on motion capture magnetic resonance imaging MRI compared normal controls. addition, explored if responses patients neostigmine challenge differed from healthy volunteers. Methods Twenty volunteers (mean age 28, range 22–48) 11...
<b>Background and study aims:</b> Understanding patients' experience of screening programs is crucial for service improvement. The English Bowel Cancer Screening Programme (BCSP) aims to achieve this by sending out questionnaires all patients who undergo a colonoscopy following an abnormal fecal occult blood test result. This used the questionnaire data report experiences these patients. <b>Patients methods:</b> Data on underwent between 2011 2012 were extracted from BCSP database....
INTRODUCTION: Esophagogastric junction outflow obstruction (EGJOO) defined on high-resolution esophageal manometry (HRM) poses a management dilemma given marked variability in clinical manifestations. We hypothesized that findings from provocative testing (rapid drink challenge and solid swallows) could determine the relevance of EGJOO. METHODS: In retrospective cohort study, we included consecutive subjects between May 2016 January 2020 with Standard HRM 5-mL water swallows was followed by...
Abstract Objectives Predicting longer term response to biological therapy for small bowel Crohn’s disease (SBCD) is an unmet clinical need. Diffusion-weighted MR imaging (DWI) may indicate activity, but its predictive ability, if any, unknown. We investigated the prognostic value of DWI one year or remission (RoR) in SBCD patients commencing biologic therapy, including incremental over C-reactive protein (CRP) and faecal calprotectin (FC). Methods A subset participants a prospective,...
Abstract Background Small bowel Crohn’s disease (SBCD) is increasingly treated with biological therapies. Predicting response or remission (RoR) for individual patients difficult and complicates treatment strategy. We aimed to determine if motility magnetic resonance imaging (mMRI) superior CRP fecal calprotectin (FC) the prediction of RoR at 1 year in commencing biologics SBCD. Methods Prospective, multicenter (n = 13) cohort study active non-stricturing SBCD requiring anti-TNFα...